Neutrino Trapping and Out-of-Equilibrium Effects in Binary Neutron-Star Merger Remnants.

We study out-of-thermodynamic-equilibrium effects in neutron-star mergers with 3D general-relativistic neutrino-radiation large-eddy simulations. During mergers, the cores of the neutron stars remain cold (T∼ a few MeV) and out of thermodynamic equilibrium with trapped neutrinos originating from the hot collisional interface between the stars. However, within ∼2 to 3 ms matter and neutrinos reach equilibrium everywhere in the remnant massive neutron star. Our results show that dissipative effects, such as bulk viscosity, if present, are only active for a short window of time after the merger.

Constraints on the Maximum Densities of Neutron Stars from Postmerger Gravitational Waves with Third-Generation Observations.

Using data from 289 numerical relativity simulations of binary neutron star mergers, we identify, for the first time, a robust quasiuniversal relation connecting the postmerger peak gravitational-wave frequency and the value of the density at the center of the maximum mass nonrotating neutron star. This relation offers a new possibility for precision equation-of-state constraints with next-generation ground-based gravitational-wave interferometers. Mock Einstein Telescope observations of fiducial events indicate that Bayesian inferences can constrain the maximum density to ∼15% (90% credibility level) for a single signal at the minimum sensitivity threshold for a detection. If the postmerger signal is included in a full-spectrum (inspiral-merger-postmerger) analysis of such a signal, the pressure-density function can be tightly constrained up to the maximum density, and the maximum neutron star mass can be measured with an accuracy better than 12% (90% credibility level).

Probing the Incompressibility of Nuclear Matter at Ultrahigh Density through the Prompt Collapse of Asymmetric Neutron Star Binaries.

Using 250 neutron star merger simulations with microphysics, we explore for the first time the role of nuclear incompressibility in the prompt collapse threshold for binaries with different mass ratios. We demonstrate that observations of prompt collapse thresholds, either from binaries with two different mass ratios or with one mass ratio but combined with the knowledge of the maximum neutron star mass or compactness, will constrain the incompressibility at the maximum neutron star density K_{max} to within tens of percent. This otherwise inaccessible measure of K_{max} can potentially reveal the presence of hyperons or quarks inside neutron stars.

A large-scale dynamo and magnetoturbulence in rapidly rotating core-collapse supernovae.

Magnetohydrodynamic turbulence is important in many high-energy astrophysical systems, where instabilities can amplify the local magnetic field over very short timescales. Specifically, the magnetorotational instability and dynamo action have been suggested as a mechanism for the growth of magnetar-strength magnetic fields (of 10(15) gauss and above) and for powering the explosion of a rotating massive star. Such stars are candidate progenitors of type Ic-bl hypernovae, which make up all supernovae that are connected to long γ-ray bursts. The magnetorotational instability has been studied with local high-resolution shearing-box simulations in three dimensions, and with global two-dimensional simulations, but it is not known whether turbulence driven by this instability can result in the creation of a large-scale, ordered and dynamically relevant field. Here we report results from global, three-dimensional, general-relativistic magnetohydrodynamic turbulence simulations. We show that hydromagnetic turbulence in rapidly rotating protoneutron stars produces an inverse cascade of energy. We find a large-scale, ordered toroidal field that is consistent with the formation of bipolar magnetorotationally driven outflows. Our results demonstrate that rapidly rotating massive stars are plausible progenitors for both type Ic-bl supernovae and long γ-ray bursts, and provide a viable mechanism for the formation of magnetars. Moreover, our findings suggest that rapidly rotating massive stars might lie behind potentially magnetar-powered superluminous supernovae.

Positrons and 511 keV Radiation as Tracers of Recent Binary Neutron Star Mergers.

Neutron-rich material ejected from neutron star-neutron star (NS-NS) and neutron star-black-hole (NS-BH) binary mergers is heated by nuclear processes to temperatures of a few hundred keV, resulting in a population of electron-positron pairs. Some of the positrons escape from the outer layers of the ejecta. We show that the population of low-energy positrons produced by NS-NS and NS-BH mergers in the Milky Way can account for the observed 511-keV line from the Galactic center (GC). Moreover, we suggest how positrons and the associated 511-keV emission can be used as tracers of recent mergers. Recent discovery of 511-keV emission from the ultrafaint dwarf galaxy Reticulum II, consistent with a rare NS-NS merger event, provides a smoking-gun signature of our proposal.

Gravitational-Wave Luminosity of Binary Neutron Stars Mergers.

We study the gravitational-wave peak luminosity and radiated energy of quasicircular neutron star mergers using a large sample of numerical relativity simulations with different binary parameters and input physics. The peak luminosity for all the binaries can be described in terms of the mass ratio and of the leading-order post-Newtonian tidal parameter solely. The mergers resulting in a prompt collapse to black hole have the largest peak luminosities. However, the largest amount of energy per unit mass is radiated by mergers that produce a hypermassive neutron star or a massive neutron star remnant. We quantify the gravitational-wave luminosity of binary neutron star merger events, and set upper limits on the radiated energy and the remnant angular momentum from these events. We find that there is an empirical universal relation connecting the total gravitational radiation and the angular momentum of the remnant. Our results constrain the final spin of the remnant black hole and also indicate that stable neutron star remnant forms with super-Keplerian angular momentum.

Cost-effectiveness of hypothetical new cancer drugs in patients with advanced small-cell lung cancer: results of a markov chain model.

BACKGROUND: In the last decade, a number of new treatment modalities have been developed for patients with small cell lung cancer (SCLC). The clinical effects are encouraging, but little is known about the costs and cost-effectiveness of new drugs. METHODS: A Markov chain model has been developed to project patient outcomes and costs for patients with advanced SCLC. All patients in the control group were treated with etoposide-cisplatin chemotherapy. Patients in the study group received a hypothetical new drug. The model consisted of four states: response, stable disease, progressive disease, and death. Estimates of transition probabilities were calculated using published data on survival and recurrence-free survival. For the cost analysis and utility calculation, published data and expert opinion were used as sources. The duration of the follow-up was maximal 2 years. RESULTS: The total treatment costs in the etoposide-cisplatin group amounted to euro16 038 and in the alternative treatment groups between euro16 644 and euro18 171. The number of life years and quality adjusted life years (QALYs) gained were very small, around 16 days. The cost-effectiveness ratio varied between euro22 208 and euro81 443 and the cost-utility ratio varied accordingly. Results of the sensitivity analysis showed that the results were robust in favor of etoposide-cisplatin treatment. CONCLUSION: SCLC is an illness with a poor prognosis which needed substantial healthcare resources to optimise patient survival and overall quality of life. New treatment modalities with better outcome and favourable cost-effective profiles can hopefully be developed.