Detalhe da pesquisa
1.
Stabilized trimeric peptide immunogens of the complete HIV-1 gp41 N-heptad repeat and their use as HIV-1 vaccine candidates.
Proc Natl Acad Sci U S A;
121(22): e2317230121, 2024 May 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38768344
2.
Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
Bioorg Med Chem Lett;
27(9): 2038-2046, 2017 05 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28285916
3.
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett;
26(1): 126-32, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26602277
4.
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett;
25(21): 4893-4898, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26077491
5.
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Bioorg Med Chem Lett;
25(3): 444-50, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25577040
6.
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett;
22(18): 5903-8, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22892116
7.
C-O cross-coupling of activated aryl and heteroaryl halides with aliphatic alcohols.
Angew Chem Int Ed Engl;
51(36): 9071-4, 2012 Sep 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22887962
8.
Regio- and enantioselective catalytic cyclization of pyrroles onto N-acyliminium ions.
Org Lett;
10(8): 1577-80, 2008 Apr 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18341346
9.
Synthesis and Antiviral Evaluation of Carbocyclic Nucleoside Analogs of Nucleoside Reverse Transcriptase Translocation Inhibitor MK-8591 (4'-Ethynyl-2-fluoro-2'-deoxyadenosine).
J Med Chem;
61(20): 9218-9228, 2018 10 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30265808
10.
Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193.
Mol Imaging Biol;
18(4): 579-87, 2016 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26596571
11.
Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem;
58(20): 8154-65, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26397965
12.
Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance.
Diabetes;
63(1): 300-11, 2014 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24101672
13.
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Neuropharmacology;
64: 215-23, 2013 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22750078
14.
Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem;
59(1): 486, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26709958
15.
Catalytic asymmetric total syntheses of quinine and quinidine.
J Am Chem Soc;
126(3): 706-7, 2004 Jan 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14733531
16.
Enantioselective Pictet-Spengler-type cyclizations of hydroxylactams: H-bond donor catalysis by anion binding.
J Am Chem Soc;
129(44): 13404-5, 2007 Nov 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17941641