DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy.

Diabetic neuropathy (DN) is a painful, chronic ailment that affects a large segment of diabetic population worldwide. Current medications such as pregabalin or duloxetine treat only the pain symptom associated with DN, but not the underlying nerve damage. DDD-028 (1) is a small molecule that displays potent pain-relieving activity in streptozotocin (STZ)-induced rodent model of DN. Combined with other studies indicating that DDD-028 suppresses astrogliosis and nerve damage induced by the anti-cancer drug, paclitaxel, the present study suggests that DDD-028 would be useful as a disease modifying therapeutic in the treatment of DN. The 3-dimensional structure of DDD-028 was confirmed by single crystal X-ray crystallography.

Unveiling photoinduced electron transfer in cobalt(iii)-R-pyridine complexes anchored to anatase nanocrystals: photoluminescence and magnetic studies.

In this study, we synthesized mixed ligand complexes of the cis-[Co(tn)2(Rpy)Br]Br2 type using a novel mechanochemical approach. Characterization involved spectral measurements and single crystal X-ray diffraction analysis, confirming the structure of the cis-[Co(tn)2(4-Mepy)Br]Br2 complex. The single crystal refinement data revealed a monoclinic crystal system with a distorted octahedral geometry. The choice of the sixth ligand influenced the emission and magnetic properties, showing a ferromagnetic character in the Co(iii)-complex environment. We investigated efficient electron transfer to the cobalt(iii) center using TiO2 nanoparticles under UV-light irradiation. The adsorption characteristics of cis-[Co(tn)2(Rpy)Br]Br2 in aqueous 2-propanol varied, leading to surface compound formation. Under UV irradiation, the anatase surface exhibited remarkable adsorption capabilities, facilitating efficient electron transfer to the Co(iii) center and resulting in a high photoefficiency for Co(ii) formation. Our study has put forward a model for interfacial electron transfer (IET), taking into account the overlap between the TiO2 conduction band and the acceptor level of the Co center, as well as the electronic coupling between the donor level of the Ti center and the acceptor level of the Co center. This model sheds light on the accumulation of electrons for reducing the adhered complex ion. The IET process was corroborated by the conversion of 2-propanol into acetone, as verified by 1H NMR technique. Overall, our findings provide novel insights into the role of the Rpy moiety in modifying the structure of the TiO2-cobalt(iii)-Rpy compound and propose a mechanism for IET reactions, thus advancing the field.