Detalhe da pesquisa
1.
Unity among the diverse RNA-guided CRISPR-Cas interference mechanisms.
J Biol Chem;
300(6): 107295, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38641067
2.
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit.
Mol Cell;
68(1): 15-25, 2017 Oct 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28985502
3.
DNase H Activity of Neisseria meningitidis Cas9.
Mol Cell;
60(2): 242-55, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26474066
4.
Molecular Details of DNA Integration by CRISPR-Associated Proteins During Adaptation in Bacteria and Archaea.
Adv Exp Med Biol;
1414: 27-43, 2023.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35852729
5.
Crystal structures of an unmodified bacterial tRNA reveal intrinsic structural flexibility and plasticity as general properties of unbound tRNAs.
RNA;
26(3): 278-289, 2020 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31848215
6.
Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence.
Biochemistry;
60(49): 3783-3800, 2021 12 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34757726
7.
CRISPR type II-A subgroups exhibit phylogenetically distinct mechanisms for prespacer insertion.
J Biol Chem;
295(32): 10956-10968, 2020 08 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32513871
8.
Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance.
Biochemistry;
58(14): 1905-1917, 2019 04 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30916546
9.
Methanopyrus kandleri topoisomerase V contains three distinct AP lyase active sites in addition to the topoisomerase active site.
Nucleic Acids Res;
44(7): 3464-74, 2016 Apr 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26908655
10.
Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V.
J Biol Chem;
289(42): 28898-909, 2014 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25135643
11.
Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies.
Nucleic Acids Res;
41(1): 657-66, 2013 Jan 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23125368
12.
Optimized protocols for the characterization of Cas12a activities.
Methods Enzymol;
679: 97-129, 2023.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36682874
13.
idMotif: An Interactive Motif Identification in Protein Sequences.
IEEE Comput Graph Appl;
PP2023 Dec 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38127603
14.
Differential Divalent Metal Binding by SpyCas9's RuvC Active Site Contributes to Nonspecific DNA Cleavage.
CRISPR J;
6(6): 527-542, 2023 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38108519
15.
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects.
CRISPR J;
5(2): 329-340, 2022 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35438515
16.
Structural studies of type I topoisomerases.
Nucleic Acids Res;
37(3): 693-701, 2009 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19106140
17.
The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage.
FEBS Lett;
595(7): 892-912, 2021 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33523494
18.
The CRISPR-Cas Mechanism for Adaptive Immunity and Alternate Bacterial Functions Fuels Diverse Biotechnologies.
Front Cell Infect Microbiol;
10: 619763, 2020.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33585286
19.
Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues.
J Am Chem Soc;
131(3): 1243-50, 2009 Jan 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19099445
20.
Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain.
Elife;
82019 07 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31361218