Detalhe da pesquisa
1.
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
Immunity;
2024 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38788712
2.
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance.
Nature;
623(7989): 1053-1061, 2023 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37844613
3.
Machine learning estimation of human body time using metabolomic profiling.
Proc Natl Acad Sci U S A;
120(18): e2212685120, 2023 05 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37094145
4.
Assessing cognitive toxicity in early phase trials - What are we missing?
Psychooncology;
31(3): 405-415, 2022 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34651364
5.
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
Bioorg Med Chem Lett;
42: 128050, 2021 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33887439
6.
A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.
Br J Cancer;
123(4): 542-555, 2020 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32439931
7.
Effect of acute total sleep deprivation on plasma melatonin, cortisol and metabolite rhythms in females.
Eur J Neurosci;
51(1): 366-378, 2020 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30929284
8.
Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.
Metabolomics;
16(4): 50, 2020 04 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32285223
9.
International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis.
Anal Chem;
91(22): 14407-14416, 2019 11 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31638379
10.
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Angew Chem Int Ed Engl;
58(2): 515-519, 2019 01 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30431220
11.
Investigation of metabolites for estimating blood deposition time.
Int J Legal Med;
132(1): 25-32, 2018 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28780758
12.
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Br J Cancer;
116(9): 1166-1176, 2017 Apr 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28334731
13.
Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma.
Anal Chem;
89(1): 656-665, 2017 01 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27959516
14.
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat Chem Biol;
11(12): 973-980, 2015 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26502155
15.
Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.
Xenobiotica;
47(9): 771-777, 2017 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27618572
16.
Effect of sleep deprivation on the human metabolome.
Proc Natl Acad Sci U S A;
111(29): 10761-6, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25002497
17.
Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library.
Chemistry;
22(16): 5657-64, 2016 Apr 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26929153
18.
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.
Bioorg Med Chem Lett;
26(5): 1443-51, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26852363
19.
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.
Bioorg Med Chem Lett;
25(19): 4203-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26296477
20.
Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.
Proc Natl Acad Sci U S A;
109(20): E1267-76, 2012 May 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22529373