Detalhe da pesquisa
1.
BET bromodomain inhibitors regulate keratinocyte plasticity.
Nat Chem Biol;
17(3): 280-290, 2021 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33462494
2.
Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical MatterâCompounds with Novel Mechanisms from High-Throughput Screening Profiles.
ACS Chem Biol;
19(4): 938-952, 2024 04 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38565185
3.
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Sci Signal;
16(768): eabh1083, 2023 01 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36649377
4.
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Cell Chem Biol;
30(9): 1156-1168.e7, 2023 09 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37689063
5.
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
bioRxiv;
2023 Feb 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36909640
6.
Small-molecule inhibition of APT1 affects Ras localization and signaling.
Nat Chem Biol;
6(6): 449-56, 2010 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20418879
7.
Probing the bioactivity-relevant chemical space of robust reactions and common molecular building blocks.
J Chem Inf Model;
52(5): 1167-78, 2012 May 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22512717
8.
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery.
ACS Chem Biol;
17(6): 1401-1414, 2022 06 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35508359
9.
Interactive exploration of chemical space with Scaffold Hunter.
Nat Chem Biol;
5(8): 581-3, 2009 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19561620
10.
Bioactivity-guided mapping and navigation of chemical space.
Nat Chem Biol;
5(8): 585-92, 2009 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19561619
11.
Mining for bioactive scaffolds with scaffold networks: improved compound set enrichment from primary screening data.
J Chem Inf Model;
51(7): 1528-38, 2011 Jul 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21615076
12.
A collection of robust organic synthesis reactions for in silico molecule design.
J Chem Inf Model;
51(12): 3093-8, 2011 Dec 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22077721
13.
Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.
Angew Chem Int Ed Engl;
50(42): 9832-7, 2011 Oct 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21905185
14.
Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes.
Sci Rep;
10(1): 9670, 2020 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32541899
15.
Synthesis and structure-activity correlation of a brunsvicamide-inspired cyclopeptide collection.
Chembiochem;
10(7): 1153-62, 2009 May 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19360807
16.
Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.
Bioorg Med Chem;
17(15): 5708-15, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19574055
17.
Positive and negative modulation of group I metabotropic glutamate receptors.
J Med Chem;
51(3): 634-47, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18173231
18.
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery.
Nat Commun;
9(1): 4307, 2018 10 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30333485
19.
A pseudo-ligand approach to virtual screening.
Comb Chem High Throughput Screen;
9(5): 359-64, 2006 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16787149
20.
A scaffold-tree-merging strategy for prospective bioactivity annotation of gamma-pyrones.
Angew Chem Int Ed Engl;
49(21): 3666-70, 2010 May 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20394088