Corrigendum: Home-based exercise program in the indeterminate form of Chagas disease (PEDI-CHAGAS study): a study protocol for a randomized clinical trial.

[This corrects the article DOI: 10.3389/fmed.2022.1087188.].

A new strategy for the implementation of an aerobic training session.

The objectives were to propose a new strategy for adjusting aerobic training variables based on the eighth American College of Sports Medicine (ACSM) guidelines and maximal aerobic power (&OV0312;O2max) and to establish energy expenditure (EE) recommendations for training, which depend on a subject's body mass (BM). Exclusively based on aerobic training recommendations that are available in the ACSM guidelines, 16 equally partitioned subcategories were created from the slope of a linear regression between the lower (16.4 ml·kg(-1)·min(-1)) and upper (61.2 ml·kg(-1)·min(-1)) limits of VO(2max) percentile tables and all aerobic variables (intensity: 30-85%Reserve, duration: 60-300 min·wk(-1), frequency: 3-5 d·wk(-1), and EE: 1,000-4,000 kcal·wk). ACSM's EE (EE(ACSM)) recommendation was compared to EE based on VO(2max) (EE(Actual)), BM, exercise intensity and duration combined, for five BM categories (60 to 100 kg). The following equations were generated to adjust aerobic training: Intensity (%(Reserve)) = VO(2max) (ml·kg(-1)·min(-1)) × 1.23 + 9.85, Duration (min·wk(-1)) = VO(2max) × 5.36-27.91, Frequency (d·wk(-1) = VO(2max) × 0.044 + 2.27, EE(ACSM) (kcal·wk(-1)) =VO(2max) × 82.61-1,055.29, and EE(Actual) (kcal·wk(-1)) = ([V(O2max) - 3.5] × Intensity + 3.5) × BM (kg)/200 × Frequency. A comparison of EE(ACSM) and EE(Actual) for 5 BM and 3 aerobic fitness categories demonstrated an effect size classification that is equal or superior to "large" in 9 of 15 comparisons, suggesting that EE(ACSM) adjustment is inadequate at least 60% of the time. Despite the need to verify the adequacy of the linear model and perform future cross-sectional and longitudinal studies, the present proposal first provides criteria to adjust aerobic training variables consistent with subject capacity, thus diminishing the risk of the imprecise aerobic prescription.

Home-based exercise program in the indeterminate form of Chagas disease (PEDI-CHAGAS study): A study protocol for a randomized clinical trial.

Background: Chagas disease (CD) is a neglected endemic disease with worldwide impact due to migration. Approximately 50-70% of individuals in the chronic phase of CD present the indeterminate form, characterized by parasitological and/or serological evidence of Trypanosoma cruzi infection, but without clinical signs and symptoms. Subclinical abnormalities have been reported in indeterminate form of CD, including pro-inflammatory states and alterations in cardiac function, biomarkers and autonomic modulation. Moreover, individuals with CD are usually impacted on their personal and professional life, making social insertion difficult and impacting their mental health and quality of life (QoL). Physical exercise has been acknowledged as an important strategy to prevent and control numerous chronic-degenerative diseases, but unexplored in individuals with the indeterminate form of CD. The PEDI-CHAGAS study (which stands for "Home-Based Exercise Program in the Indeterminate Form of Chagas Disease" in Portuguese) aims to evaluate the effects of a home-based exercise program on physical and mental health outcomes in individuals with indeterminate form of CD. Methods and design: The PEDI-CHAGAS is a two-arm (exercise and control) phase 3 superiority randomized clinical trial including patients with indeterminate form of CD. The exclusion criteria are <18 years old, evidence of non-Chagasic cardiomyopathy, musculoskeletal or cognitive limitations that preclude the realization of exercise protocol, clinical contraindication for regular exercise, and regular physical exercise (≥1 × per week). Participants will be assessed at baseline, and after three and 6 months of follow-up. The primary outcome will be QoL. Secondary outcomes will include blood pressure, physical fitness components, nutritional status, fatigability, autonomic modulation, cardiac morphology and function, low back pain, depression and anxiety, stress, sleep quality, medication use and adherence, and biochemical, inflammatory and cardiac biomarkers. Participants in the intervention group will undergo a home-based exercise program whilst those in the control group will receive only general information regarding the benefits of physical activity. Both groups will receive the same general nutritional counseling consisting of general orientations about healthy diets. Conclusion: The findings from the present study may support public health intervention strategies to improve physical and mental health parameters to be implemented more effectively in this population. Clinical trial registration: [https://ensaiosclinicos.gov.br/rg/RBR-10yxgcr9/], identifier [U1111-1263-0153].