Detalhe da pesquisa
1.
SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer.
Mol Cell;
83(23): 4239-4254.e10, 2023 Dec 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38065062
2.
Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs.
J Biol Chem;
298(4): 101653, 2022 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35101445
3.
Discovery and resistance mechanism of a selective CDK12 degrader.
Nat Chem Biol;
17(6): 675-683, 2021 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33753926
4.
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Nat Chem Biol;
17(11): 1157-1167, 2021 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34675414
5.
The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation.
Chem Soc Rev;
51(14): 6210-6221, 2022 Jul 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35792307
6.
Monitoring and deciphering protein degradation pathways inside cells.
Drug Discov Today Technol;
31: 61-68, 2019 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31200861
7.
3D collagen alignment limits protrusions to enhance breast cancer cell persistence.
Biophys J;
107(11): 2546-58, 2014 Dec 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25468334
8.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nat Commun;
15(1): 482, 2024 Jan 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38228616
9.
Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression.
Crit Rev Eukaryot Gene Expr;
23(2): 139-57, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23582036
10.
Monitoring PROTAC interactions in biochemical assays using Lumit immunoassays.
Methods Enzymol;
681: 81-113, 2023.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36764765
11.
Aligned collagen is a prognostic signature for survival in human breast carcinoma.
Am J Pathol;
178(3): 1221-32, 2011 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21356373
12.
Kinetic Detection of E3:PROTAC:Target Ternary Complexes Using NanoBRET Technology in Live Cells.
Methods Mol Biol;
2365: 151-171, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34432243
13.
CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2.
SLAS Discov;
26(4): 560-569, 2021 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33190579
14.
R-Ras regulates beta1-integrin trafficking via effects on membrane ruffling and endocytosis.
BMC Cell Biol;
11: 14, 2010 Feb 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20167113
15.
In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia.
Proc Natl Acad Sci U S A;
104(49): 19494-9, 2007 Dec 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18042710
16.
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds using HiBiT CRISPR Cell Lines.
J Vis Exp;
(165)2020 11 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33226022
17.
Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3.
Curr Protoc Pharmacol;
91(1): e81, 2020 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33332748
18.
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7.
J Med Chem;
62(2): 699-726, 2019 01 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30540463
19.
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action.
ACS Chem Biol;
13(9): 2758-2770, 2018 09 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30137962
20.
In vivo multiphoton fluorescence lifetime imaging of protein-bound and free nicotinamide adenine dinucleotide in normal and precancerous epithelia.
J Biomed Opt;
12(2): 024014, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17477729