RESUMO
Belantamab-mafodotin is an innovative and selective treatment for multi-refractory/relapsed multiple myeloma (MM) patients; however, available real-life experiences on efficacy and safety are limited. In this real-world multicentric retrospective study, we enrolled 28 MM patients treated in four Hematology units of Campania region, Italy, who received a median of six treatment lines prior to belantamab-mafodotin. The overall response rate (ORR) was 40% (complete remission, CR, 11%; very good partial remission, VGPR, 11%; and partial remission, PR, 18%), with a median progression-free survival (PFS) and overall survival (OS) of 3 and 8 months, respectively. One of the most frequent drug-related adverse events was keratopathy observed in nine (32%) patients, leading to therapy discontinuation in only three (11%) of them. Moreover, 22 out of 28 total patients who were treated with at least two administrations achieved an ORR of 50% (CR, 14%; VGPR, 14%; and PR, 22%) with a median PFS and OS of 5 and 11 months, respectively. In conclusion, our multicentric study confirmed efficacy and safety of belantamab-mafodotin in triple-refractory MM patients even in the real-life setting.
RESUMO
In cognitive psychology, classical approaches categorize automatic and controlled processes from a dichotomous point of view. Automatic processes are believed to be rigid, whereas controlled processes are thought to be flexible. New theories have softened this dichotomous view. The aim of the present study is to examine the possibility of implementing flexibility in automatic processing through reliance on contextual features. One hundred and twenty subjects (mean age 22.4, SD = 4.2), 60 male and 60 female, participated in this study. An automatic sequence task (with and without contextual features) was used to test flexibility in automatic processing. Results showed that the use of contextual cues can increase flexibility in automatic processes. The results are discussed in light of new theories on softened automaticity.