Detalhe da pesquisa
1.
Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs.
Antimicrob Agents Chemother;
: e0164323, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38639491
2.
Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.
Malar J;
18(1): 38, 2019 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30767768
3.
Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei.
Malar J;
15(1): 588, 2016 Dec 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27923405
4.
Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.
Malar J;
13: 2, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24386891
5.
Nanoparticle formulations of decoquinate increase antimalarial efficacy against liver stage Plasmodium infections in mice.
Nanomedicine;
10(1): 57-65, 2014 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23891618
6.
The use of a prodrug approach to minimize potential CNS exposure of next generation quinoline methanols while maintaining efficacy in in vivo animal models.
Eur J Drug Metab Pharmacokinet;
39(4): 231-6, 2014 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24705994
7.
Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
J Med Chem;
67(10): 8323-8345, 2024 May 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38722757
8.
3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.
Bioorg Med Chem;
21(23): 7250-6, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24139941
9.
Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice.
Malar J;
10: 150, 2011 Jun 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21645370
10.
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Sci Rep;
11(1): 2121, 2021 01 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33483532
11.
Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols.
Malar J;
9: 51, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20149249
12.
Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum.
Bioorg Med Chem Lett;
20(4): 1347-51, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20097070
13.
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
ACS Med Chem Lett;
11(3): 249-257, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32184953
14.
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.
J Med Chem;
63(11): 6179-6202, 2020 06 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32390431
15.
Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.
Org Biomol Chem;
7(20): 4163-5, 2009 Oct 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19795052
16.
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
J Med Chem;
62(7): 3475-3502, 2019 04 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30852885
17.
Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation.
ACS Med Chem Lett;
9(10): 996-1001, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30344906
18.
Multiple hybrid genotypes of Leishmania (viannia) in a focus of mucocutaneous Leishmaniasis.
Am J Trop Med Hyg;
76(3): 573-8, 2007 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17360886
19.
Comparative Susceptibility of Different Mouse Strains to Liver-Stage Infection With Plasmodium berghei Sporozoites Assessed Using In Vivo Imaging.
Mil Med;
182(S1): 360-368, 2017 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28291500
20.
Long-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites.
Malar Res Treat;
2017: 7508291, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28491482