Detalhe da pesquisa
1.
Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity;
52(3): 499-512.e5, 2020 03 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32187518
2.
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Proc Natl Acad Sci U S A;
114(47): 12448-12453, 2017 11 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29109273
3.
Discovery of amino-1,4-oxazines as potent BACE-1 inhibitors.
Bioorg Med Chem Lett;
28(12): 2195-2200, 2018 07 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29764741
4.
Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria.
Haematologica;
107(6): 1483-1488, 2022 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35263983
5.
A General Strategy for Targeting Drugs to Bone.
Angew Chem Int Ed Engl;
54(48): 14575-9, 2015 Nov 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26457482
6.
Ligandability Assessment of IL-1ß by Integrated Hit Identification Approaches.
J Med Chem;
67(10): 8141-8160, 2024 May 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38728572
7.
Protein crystallization in stirred systems--scale-up via the maximum local energy dissipation.
Biotechnol Bioeng;
110(7): 1956-63, 2013 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23335375
8.
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective ß-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid ß-peptides.
Bioorg Med Chem Lett;
23(19): 5300-6, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23981898
9.
"Redirecting an anti-IL-1ß antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Commun Biol;
6(1): 997, 2023 09 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37773269
10.
Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1ß.
Nat Commun;
14(1): 5497, 2023 09 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37679328
11.
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.
Nat Chem Biol;
6(9): 660-6, 2010 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20711197
12.
IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Cell Rep;
41(3): 111489, 2022 10 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36260993
13.
Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety.
Pharmacol Ther;
229: 107925, 2022 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34171337
14.
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Bioorg Med Chem Lett;
21(7): 1942-7, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21388807
15.
Synthesis of the Potent, Selective, and Efficacious ß-Secretase (BACE1) Inhibitor NB-360.
J Med Chem;
64(8): 4677-4696, 2021 04 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33844524
16.
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious ß-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.
J Med Chem;
64(20): 15262-15279, 2021 10 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34648711
17.
PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.
Mol Cancer Ther;
20(7): 1270-1282, 2021 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33879555
18.
Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
Bioorg Med Chem Lett;
20(6): 1924-7, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20172717
19.
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Bioorg Med Chem Lett;
20(2): 603-7, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19963375
20.
Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
Bioorg Med Chem Lett;
19(5): 1361-5, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19195886