Detalhe da pesquisa
1.
Unique challenges required reassessment and alterations to critical reagents to rescue a neutralizing antibody assay.
Bioanalysis;
: 1-11, 2024 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38884331
2.
MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice.
Behav Pharmacol;
22(2): 91-100, 2011 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21301326
3.
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists.
Bioorg Med Chem Lett;
20(15): 4700-3, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20510609
4.
Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site.
J Pharmacol Exp Ther;
326(1): 240-51, 2008 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18430863
5.
Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.
J Med Chem;
47(18): 4595-9, 2004 Aug 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15317469
6.
PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ.
J Pharmacol Toxicol Methods;
61(3): 319-28, 2010.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20132901
7.
3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).
Bioorg Med Chem Lett;
15(9): 2389-93, 2005 May 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15837331
8.
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
Bioorg Med Chem Lett;
15(6): 1565-71, 2005 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15745798
9.
Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.
Bioorg Med Chem Lett;
15(19): 4354-8, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16046122
10.
Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.
Bioorg Med Chem Lett;
15(18): 4068-72, 2005 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16005222
11.
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.
Bioorg Med Chem Lett;
14(21): 5329-32, 2004 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15454221
12.
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.
Bioorg Med Chem Lett;
14(23): 5867-72, 2004 Dec 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15501058
13.
Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.
Bioorg Med Chem Lett;
14(20): 5071-4, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15380201
14.
Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.
Mol Pharmacol;
64(4): 798-810, 2003 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14500736