Detalhe da pesquisa
1.
Defined stereoisomers of 2â³-amino NAD+ and their activity against human sirtuins and a bacterial (ADP-ribosyl) transferase.
Bioorg Med Chem;
68: 116875, 2022 08 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35716588
2.
The Current State of NAD+ -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.
Med Res Rev;
38(1): 147-200, 2018 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28094444
3.
Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions.
Chem Rec;
18(12): 1701-1707, 2018 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29931800
4.
Structure-Based Development of an Affinity Probe for Sirtuinâ 2.
Angew Chem Int Ed Engl;
55(6): 2252-6, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26748890
5.
Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development.
J Chem Inf Model;
54(1): 138-50, 2014 Jan 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24377786
6.
Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).
Biochim Biophys Acta;
1799(10-12): 726-39, 2010.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20601279
7.
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).
Bioorg Med Chem;
19(12): 3669-77, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21315612
8.
Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases.
J Med Chem;
62(5): 2582-2597, 2019 03 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30785747
9.
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.
Philos Trans R Soc Lond B Biol Sci;
373(1748)2018 06 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29685963
10.
De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation.
Nat Genet;
50(10): 1442-1451, 2018 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30224647
11.
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
J Med Chem;
59(4): 1599-612, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26696402
12.
Identification of Highly Potent Protein Kinaseâ C-Related Kinaseâ 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and inâ vitro Testing.
ChemMedChem;
11(18): 2084-94, 2016 09 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27472906
13.
Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).
Future Med Chem;
8(13): 1537-51, 2016 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27572962
14.
Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
Acta Crystallogr F Struct Biol Commun;
71(Pt 12): 1498-510, 2015 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26625292
15.
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Nat Commun;
6: 6263, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25672491
16.
Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
J Mol Biol;
426(20): 3442-53, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24657767
17.
Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.
ACS Med Chem Lett;
3(12): 1050-3, 2012 Dec 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24900427
18.
Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.
PLoS One;
7(4): e34973, 2012.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22532837
19.
Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).
J Med Chem;
54(10): 3492-9, 2011 May 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21528845
20.
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).
J Med Chem;
53(3): 1383-6, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20030343