Detalhe da pesquisa
1.
A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice.
Mol Ther;
29(6): 1970-1983, 2021 06 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33823303
2.
Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.
Proc Natl Acad Sci U S A;
111(33): 12163-8, 2014 Aug 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25092323
3.
Time course of renal proximal tubule injury, reversal, and related biomarker changes in rats following cisplatin administration.
Int J Toxicol;
32(4): 251-60, 2013 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23788329
4.
Heteroaromatic-aminomethyl quinolones: potent and selective iNOS inhibitors.
Bioorg Med Chem Lett;
22(2): 1237-41, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22182498
5.
Development of an mRNA replacement therapy for phenylketonuria.
Mol Ther Nucleic Acids;
28: 87-98, 2022 Jun 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35356682
6.
Lipid nanoparticle delivers phenylalanine ammonia lyase mRNA to the liver leading to catabolism and clearance of phenylalanine in a phenylketonuria mouse model.
Mol Genet Metab Rep;
32: 100882, 2022 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35600090
7.
Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
J Pharmacol Exp Ther;
336(2): 468-78, 2011 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21036913
8.
Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
Bioorg Med Chem Lett;
21(22): 6888-94, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21986586
9.
Urinary parameters predictive of cisplatin-induced acute renal injury in dogs.
Cytokine;
52(3): 156-62, 2010 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20655244
10.
Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA.
J Med Chem;
63(21): 12992-13012, 2020 11 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33119286
11.
KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.
Mol Pharmacol;
76(1): 153-62, 2009 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19364813
12.
Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis.
Sci Rep;
6: 37977, 2016 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27905482
13.
Medullary N-type and P/Q-type calcium channels contribute to neuropathy-induced allodynia.
Neuroreport;
16(6): 563-6, 2005 Apr 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15812308
14.
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
J Med Chem;
53(21): 7739-55, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20931971
15.
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
J Med Chem;
52(9): 3047-62, 2009 May 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19374401
16.
Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors.
Am J Physiol Gastrointest Liver Physiol;
286(4): G683-91, 2004 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14615283
17.
Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the alpha 2 delta subunit of voltage gated calcium channels.
Bioorg Med Chem Lett;
14(5): 1295-8, 2004 Mar 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14980685