Detalhe da pesquisa
1.
A phase 1 study in healthy volunteers to investigate the safety, tolerability, and pharmacokinetics of VIR-2482: a monoclonal antibody for the prevention of severe influenza A illness.
Antimicrob Agents Chemother;
68(4): e0127323, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38376227
2.
Effect of Sotrovimab on Hospitalization or Death Among High-risk Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial.
JAMA;
327(13): 1236-1246, 2022 04 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35285853
3.
Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites.
Ther Drug Monit;
43(6): 780-788, 2021 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33814540
4.
Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters.
Drug Metab Dispos;
45(7): 770-778, 2017 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28428365
5.
Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions.
Drug Metab Dispos;
45(6): 692-705, 2017 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28336578
6.
Stereoselective Metabolism of Bupropion to OH-bupropion, Threohydrobupropion, Erythrohydrobupropion, and 4'-OH-bupropion in vitro.
Drug Metab Dispos;
44(10): 1709-19, 2016 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27495292
7.
Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification.
Drug Metab Dispos;
43(11): 1823-37, 2015 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26296709
8.
Pharmacokinetics, Safety, and Tolerability of Anti-SARS-CoV-2 Monoclonal Antibody, Sotrovimab, Delivered Intravenously or Intramuscularly in Japanese and Caucasian Healthy Volunteers.
Clin Pharmacokinet;
63(1): 57-68, 2024 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37955825
9.
Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions.
Drug Metab Dispos;
41(7): 1414-24, 2013 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23620487
10.
Population pharmacokinetics and exposure-response analysis of a single dose of sotrovimab in the early treatment of patients with mild to moderate COVID-19.
CPT Pharmacometrics Syst Pharmacol;
12(6): 853-864, 2023 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36922886
11.
Safety, Virology, Pharmacokinetics, and Clinical Experience of High-Dose Intravenous Sotrovimab for the Treatment of Mild to Moderate COVID-19: An Open-Label Clinical Trial.
Open Forum Infect Dis;
10(7): ofad344, 2023 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37520411
12.
Intramuscular vs Intravenous SARS-CoV-2 Neutralizing Antibody Sotrovimab for Treatment of COVID-19 (COMET-TAIL): A Randomized Noninferiority Clinical Trial.
Open Forum Infect Dis;
10(8): ofad354, 2023 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37577112
13.
In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation.
Biochem Pharmacol;
123: 85-96, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27836670
14.
Identification and Structural Characterization of Three New Metabolites of Bupropion in Humans.
ACS Med Chem Lett;
7(8): 791-6, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27660681
15.
Corrigendum to "In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation" [Biochem. Pharmacol. 123(2017)85-96].
Biochem Pharmacol;
183: 114306, 2021 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33161206