Detalhe da pesquisa
1.
CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in KMT2A-Rearranged Acute Lymphoblastic Leukemia.
Int J Mol Sci;
24(17)2023 Aug 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37686014
2.
Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis.
Haematologica;
104(6): 1176-1188, 2019 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30679323
3.
Trametinib inhibits RAS-mutant MLL-rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo.
Haematologica;
103(4): e147-e150, 2018 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29419436
4.
Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants.
Haematologica;
98(6): 937-44, 2013 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23403319
5.
Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia.
Exp Hematol Oncol;
12(1): 81, 2023 Sep 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37740239
6.
Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia.
Blood;
115(5): 1018-25, 2010 Feb 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19965632
7.
Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants.
Blood;
115(14): 2835-44, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20032505
8.
Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics.
Leukemia;
36(1): 58-67, 2022 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34304246
9.
High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling.
Biomedicines;
10(3)2022 Mar 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35327440
10.
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells.
Cell Rep;
39(4): 110752, 2022 04 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35476984
11.
Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options.
Blood;
114(27): 5490-8, 2009 Dec 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19855078
12.
Clinical and molecular genetic characterization of wild-type MLL infant acute lymphoblastic leukemia identifies few recurrent abnormalities.
Haematologica;
101(3): e95-8, 2016 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26681762
13.
Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL-Rearranged Acute Lymphoblastic Leukemia.
Biomedicines;
9(7)2021 Jun 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34201500
14.
Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia.
J Clin Invest;
131(13)2021 07 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33983906
15.
High-throughput drug screening reveals Pyrvinium pamoate as effective candidate against pediatric MLL-rearranged acute myeloid leukemia.
Transl Oncol;
14(5): 101048, 2021 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33667892
16.
Decitabine mildly attenuates MLL-rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo-sensitizer.
EJHaem;
1(2): 527-536, 2020 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35844991
17.
D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia.
Haematologica;
92(11): 1565-8, 2007 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18024407
18.
Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia.
Haematologica;
92(11): 1557-60, 2007 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18024405
19.
MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations.
Oncotarget;
8(9): 14835-14846, 2017 Feb 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27588400
20.
The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study of patients treated according to DCOG or COALL protocols.
Haematologica;
91(9): 1212-21, 2006 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16956820