Detalhe da pesquisa
1.
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.
J Virol;
96(8): e0012822, 2022 04 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35343766
2.
Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a).
J Lipid Res;
63(6): 100216, 2022 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35469919
3.
Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin.
J Biol Chem;
297(4): 101177, 2021 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34508778
4.
Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers.
BMC Cancer;
22(1): 1049, 2022 Oct 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36203122
5.
Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond.
Curr Atheroscler Rep;
24(10): 821-830, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35904732
6.
Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes.
Immunity;
39(4): 711-21, 2013 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24138882
7.
The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer.
J Lipid Res;
62: 100130, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34606887
8.
The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity.
J Biol Chem;
295(7): 2068-2083, 2020 02 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31915245
9.
Hypolipidaemia among patients with PMM2-CDG is associated with low circulating PCSK9 levels: a case report followed by observational and experimental studies.
J Med Genet;
57(1): 11-17, 2020 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31391289
10.
Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice.
J Biol Chem;
294(23): 9037-9047, 2019 06 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31004037
11.
Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models.
Circ Res;
123(10): 1127-1142, 2018 10 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30359200
12.
Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).
Arterioscler Thromb Vasc Biol;
39(10): 1996-2013, 2019 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31553664
13.
The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.
Pharmacol Rev;
69(1): 33-52, 2017 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27920219
14.
Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.
J Biol Chem;
293(19): 7329-7343, 2018 05 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29593095
15.
Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions.
J Biol Chem;
293(19): 7408-7422, 2018 05 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29559555
16.
The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.
Curr Opin Lipidol;
29(2): 144-150, 2018 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29342010
17.
Thrombin activation of protein C requires prior processing by a liver proprotein convertase.
J Biol Chem;
292(25): 10564-10573, 2017 06 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28468828
18.
Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.
J Biol Chem;
292(4): 1510-1523, 2017 01 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27909053
19.
The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.
J Biol Chem;
292(5): 1573-1590, 2017 02 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27998977
20.
A single domain antibody against the Cys- and His-rich domain of PCSK9 and evolocumab exhibit different inhibition mechanisms in humanized PCSK9 mice.
Biol Chem;
399(12): 1363-1374, 2018 11 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30044755