RESUMO
A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines. This highly regioselective and one-pot process provides rapid access to highly diverse triazoles.
Assuntos
Amidinas/química , Ácidos Carboxílicos/química , Hidrazinas/química , Hidrazinas/síntese química , Triazóis/síntese química , Catálise , Técnicas de Química Combinatória , Estrutura MolecularRESUMO
The chemoselective functionalization of a range of dihaloaromatics with methyl, cyclopropyl, and higher alkyl Grignard reagents via iron-catalyzed cross-coupling is described. The site selectivity of C-X (X = halogen) activation is determined by factors such as the position of the halogen on the ring, the solvent, and the nucleophile. A one-pot protocol for the chemoselective synthesis of mixed dialkyl heterocycles is achieved solely employing iron catalysis.
Assuntos
Alcanos/química , Reagentes de Ligações Cruzadas/química , Halogênios/química , Hidrocarbonetos Halogenados/química , Ferro/química , Catálise , Estrutura MolecularRESUMO
Nitroalkenes readily undergo palladium-catalyzed [3 + 2] cycloaddition with trimethylenemethane to generate nitrocyclopentanes in excellent yield and enantioselectivity. Furthermore, the products thus formed are highly versatile synthetic intermediates and provide convenient access to both cyclopentylamines and cyclopentenones.