Detalhe da pesquisa
1.
Tailored horseshoe-shaped nicotinonitrile scaffold as dual promising c-Met and Pim-1 inhibitors: Design, synthesis, SAR and in silico study.
Bioorg Chem;
143: 106988, 2024 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37995644
2.
New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling.
Bioorg Chem;
150: 107511, 2024 May 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38870705
3.
Development of new thieno[2,3-d]pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities.
Bioorg Chem;
143: 107101, 2024 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38183682
4.
Identification of 3-(5-cyano-6-oxo-pyridin-2-yl)benzenesulfonamides as novel anticancer agents endowed with EGFR inhibitory activity.
Arch Pharm (Weinheim);
357(1): e2300449, 2024 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37828544
5.
Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights.
Bioorg Chem;
140: 106799, 2023 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37625210
6.
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors.
J Enzyme Inhib Med Chem;
38(1): 2203389, 2023 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37122176
7.
Chronotherapeutic neuroprotective effect of verapamil against lipopolysaccharide-induced neuroinflammation in mice through modulation of calcium-dependent genes.
Mol Med;
28(1): 139, 2022 11 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36435759
8.
Ketoprofen, piroxicam and indomethacin-suppressed quorum sensing and virulence factors in Acinetobacter baumannii.
J Appl Microbiol;
133(4): 2182-2197, 2022 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35503000
9.
Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition.
Bioorg Chem;
129: 106126, 2022 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36108589
10.
New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies.
Bioorg Chem;
120: 105644, 2022 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35121552
11.
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity.
J Enzyme Inhib Med Chem;
37(1): 1043-1052, 2022 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35437108
12.
Could the analgesic drugs, paracetamol and indomethacin, function as quorum sensing inhibitors?
Microb Pathog;
158: 105097, 2021 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34284088
13.
Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections.
Eur J Clin Microbiol Infect Dis;
39(9): 1687-1702, 2020 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32328851
14.
New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study.
Bioorg Med Chem Lett;
30(23): 127611, 2020 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33068712
15.
Synthesis of imidazolidine-2,4-dione and 2-thioxoimidazolidin-4-one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa.
Arch Pharm (Weinheim);
353(5): e1900352, 2020 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32134150
16.
Study of the binding interaction of salmon sperm DNA with nintedanib, a tyrosine kinase inhibitor using multi-spectroscopic, thermodynamic, and in silico approaches.
J Biomol Struct Dyn;
42(3): 1170-1180, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37079322
17.
Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin.
Biomed Pharmacother;
171: 116151, 2024 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38262148
18.
DFT and molecular simulation validation of the binding activity of PDEδ inhibitors for repression of oncogenic k-Ras.
PLoS One;
19(3): e0300035, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38457483
19.
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments.
J Med Chem;
67(1): 492-512, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38117230
20.
A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments.
Eur J Med Chem;
274: 116527, 2024 Aug 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38810335