Detalhe da pesquisa
1.
Identification of essential sites of lipid peroxidation in ferroptosis.
Nat Chem Biol;
19(6): 719-730, 2023 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36747055
2.
Characterization of a patient-derived variant of GPX4 for precision therapy.
Nat Chem Biol;
18(1): 91-100, 2022 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34931062
3.
Quantitative High-Field NMR- and Mass Spectrometry-Based Fatty Acid Sequencing Reveals Internal Structure in Ru-Catalyzed Deuteration of Docosahexaenoic Acid.
Anal Chem;
94(38): 12971-12980, 2022 09 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36098546
4.
Pharmacokinetics and metabolism in mouse retina of bis-allylic deuterated docosahexaenoic acid (D-DHA), a new dry AMD drug candidate.
Exp Eye Res;
222: 109193, 2022 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35870486
5.
Toward Quantitative Sequencing of Deuteration of Unsaturated Hydrocarbon Chains in Fatty Acids.
Anal Chem;
93(23): 8238-8247, 2021 06 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34048647
6.
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation.
Nat Chem Biol;
14(5): 507-515, 2018 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29610484
7.
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.
Proc Natl Acad Sci U S A;
113(34): E4966-75, 2016 08 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27506793
8.
Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo.
J Am Chem Soc;
140(1): 235-243, 2018 01 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29206462
9.
Randomized, clinical trial of RT001: Early signals of efficacy in Friedreich's ataxia.
Mov Disord;
33(6): 1000-1005, 2018 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29624723
10.
Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study.
Molecules;
23(12)2018 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30558277
11.
A strong developmental isotope effect in Caenorhabditis elegans induced by 5,5-deuterated lysine.
Amino Acids;
49(5): 887-894, 2017 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28161800
12.
Rational Manipulation of DNA Methylation by Using Isotopically Reinforced Cytosine.
Chembiochem;
17(21): 2018-2021, 2016 11 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27595234
13.
Deuteration protects asparagine residues against racemization.
Amino Acids;
48(9): 2189-96, 2016 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27169868
14.
Lipid peroxidation is essential for α-synuclein-induced cell death.
J Neurochem;
133(4): 582-9, 2015 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25580849
15.
Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations.
J Am Chem Soc;
136(3): 838-41, 2014 Jan 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24380377
16.
Arachidonic acid: reconciling the dichotomy of its oxidative cascade through specific deuteration.
Free Radic Res;
: 1-11, 2023 Oct 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37897398
17.
Free Radical Chain Reactions and Polyunsaturated Fatty Acids in Brain Lipids.
ACS Omega;
7(29): 25337-25345, 2022 Jul 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35910174
18.
Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload.
Aging Cell;
21(4): e13579, 2022 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35257475
19.
Deuterated Arachidonic Acid Ameliorates Lipopolysaccharide-Induced Lung Damage in Mice.
Antioxidants (Basel);
11(4)2022 Mar 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35453366
20.
Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in a Mouse Model of Poor RBC Storage.
Front Physiol;
13: 868578, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35557972