RESUMO
Choline deficiency leads to steatohepatitis, elevated transaminases, susceptibility to septic shock, and an increased risk of central catheter thrombosis. Children with intestinal failure (IF) are at risk for choline deficiency. In an unblinded, open-label study, we studied 7 children with IF on parenteral nutrition, measured their plasma free choline level, and, if low, supplemented enterally with adequate intake (AI) doses of choline. Four to 6 weeks later we remeasured their plasma free choline. Unlike adults, infants did not respond to oral choline supplementation at AI doses. Additionally, we have calculated plasma free choline percentiles versus age for normal children.
Assuntos
Colina/uso terapêutico , Suplementos Nutricionais , Enteropatias/dietoterapia , Intestinos/fisiopatologia , Administração Oral , Adolescente , Fatores Etários , Criança , Colina/sangue , Deficiência de Colina/etiologia , Deficiência de Colina/prevenção & controle , Feminino , Humanos , Lactente , Enteropatias/sangue , Enteropatias/fisiopatologia , Masculino , Nutrição Parenteral , Projetos Piloto , Síndrome do Intestino Curto/sangue , Síndrome do Intestino Curto/dietoterapia , Síndrome do Intestino Curto/fisiopatologiaRESUMO
The original version of this article contained an error in one of the author name. The co-author name was published as "Elliot Fishman", instead it should be "Elliot K. Fishman". The original article has been corrected.