1.
J Org Chem
; 87(18): 12460-12469, 2022 09 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36067376
RESUMO
A high efficiency protocol was developed for the synthesis of 2,5-disubstituted oxazoles via iodine-promoted oxidative domino cyclization. These reactions were performed with readily available methyl azaarenes and α-amino ketones under metal-free conditions. This protocol is a simple method with high functional group compatibility, a wide range of substrates, and excellent yield, providing a new way to synthesize azaarene-attached oxazoles.