Detalhe da pesquisa
1.
The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
Bioorg Med Chem Lett;
27(23): 5167-5171, 2017 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29113762
2.
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett;
26(1): 126-32, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26602277
3.
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J Med Chem;
67(5): 3935-3958, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38365209
4.
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.
J Med Chem;
66(2): 1157-1171, 2023 01 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36624931
5.
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
ACS Chem Biol;
17(9): 2595-2604, 2022 09 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36044633
6.
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.
Bioorg Med Chem Lett;
20(2): 531-6, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20004574
7.
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
J Med Chem;
60(16): 6771-6780, 2017 08 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28418656
8.
Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia.
Curr Top Med Chem;
6(8): 771-85, 2006.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16719816
9.
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.
ACS Med Chem Lett;
7(7): 702-7, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27437081
10.
Recent advances in positive allosteric modulators of metabotropic glutamate receptors.
Curr Opin Drug Discov Devel;
8(4): 449-57, 2005 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16022181
11.
Applications of microwave-assisted organic synthesis on the multigram scale.
Curr Opin Drug Discov Devel;
8(6): 701-8, 2005 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16312146
12.
Accelerating lead development by microwave-enhanced medicinal chemistry.
Drug Discov Today Technol;
2(2): 155-61, 2005.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24981843
13.
Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.
J Med Chem;
58(19): 7888-94, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26378882
14.
A convergent synthesis of the tricyclic architecture of the guanacastepenes featuring a selective ring fragmentation.
Org Lett;
4(12): 2063-6, 2002 Jun 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12049518
15.
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
J Med Chem;
51(20): 6471-7, 2008 Oct 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18817368
16.
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
J Med Chem;
51(13): 3692-5, 2008 Jul 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18540666
17.
Convergent, enantioselective syntheses of guanacastepenes A and E featuring a selective cyclobutane fragmentation.
J Am Chem Soc;
128(21): 7025-35, 2006 May 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16719483