Itch reduction using immersive virtual reality-An experimental pilot study.

In a previous proof-of-concept study we have demonstrated that visual exposure to specific colors results in pruritic or antipruritic effects. To determine the effect of "antipruritic" colors when using immersive virtual reality (VR) and to assess whether psychometric values correlate with the response to the color exposure. In this cross-sectional interventional single-center study, itch patients were exposed to their subjective "antipruritic color" (defined by the Manchester Color Wheel) in a virtual monochromatic room for 10 min using a head-mounted display. Itch intensity rating (0-10 numerical rating scale [NRS]) was repeated at 1-min intervals. Additionally, dermatology life quality index, itch-related quality of life and the Hospital Anxiety and Depression Scale questionnaires were completed. Twenty-two patients (mean age 51.9 ± 23 years, 13 females) participated in the study. Following color exposure for 10 min itch intensity was significantly reduced compared to baseline (exact Wilcoxon signed-rank test, mdn-NRS 4.5 vs 3.0; z = -3.025, p = 0.001), confirmed by the area under the curve (z = -3.118; p = 0.001). No significant correlation between itch reduction and questionnaire scores was found (Spearman's Rho for all questionnaires). Visual exposure to the "antipruritic color" using immersive VR resulted in a significant decrease in itch intensity. This aligns with previous findings on the influence of colors on itch perception. The response of the intervention appeared independent of psychometric values. Thus, color exposure using immersive VR is a promising, low-cost, rapidly-acting, easily-applicable, non-pharmacological experimental antipruritic method.

A tale of two interfaces: vitrivr at the lifelog search challenge.

The past decades have seen an exponential growth in the amount of data which is produced by individuals. Smartphones which capture images, videos and sensor data have become commonplace, and wearables for fitness and health are growing in popularity. Lifelog retrieval systems aim to aid users in finding and exploring their personal history. We present two systems for lifelog retrieval: vitrivr and vitrivr-VR, which share a common retrieval model and backend for multi-modal multimedia retrieval. They differ in the user interface component, where vitrivr relies on a traditional desktop-based user interface and vitrivr-VR has a Virtual Reality user interface. Their effectiveness is evaluated at the Lifelog Search Challenge 2021, which offers an opportunity for interactive retrieval systems to compete with a focus on textual descriptions of past events. Our results show that the conventional user interface outperformed the VR user interface. However, the format of the evaluation campaign does not provide enough data for a thorough assessment and thus to make robust statements about the difference between the systems. Thus, we conclude by making suggestions for future interactive evaluation campaigns which would enable further insights.

Interactive video retrieval evaluation at a distance: comparing sixteen interactive video search systems in a remote setting at the 10th Video Browser Showdown.

The Video Browser Showdown addresses difficult video search challenges through an annual interactive evaluation campaign attracting research teams focusing on interactive video retrieval. The campaign aims to provide insights into the performance of participating interactive video retrieval systems, tested by selected search tasks on large video collections. For the first time in its ten year history, the Video Browser Showdown 2021 was organized in a fully remote setting and hosted a record number of sixteen scoring systems. In this paper, we describe the competition setting, tasks and results and give an overview of state-of-the-art methods used by the competing systems. By looking at query result logs provided by ten systems, we analyze differences in retrieval model performances and browsing times before a correct submission. Through advances in data gathering methodology and tools, we provide a comprehensive analysis of ad-hoc video search tasks, discuss results, task design and methodological challenges. We highlight that almost all top performing systems utilize some sort of joint embedding for text-image retrieval and enable specification of temporal context in queries for known-item search. Whereas a combination of these techniques drive the currently top performing systems, we identify several future challenges for interactive video search engines and the Video Browser Showdown competition itself.

Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis.

BACKGROUND AND OBJECTIVES: The choroid plexus has been shown to play a crucial role in CNS inflammation. Previous studies found larger choroid plexus in multiple sclerosis (MS) compared with healthy controls. However, it is not clear whether the choroid plexus is similarly involved in MS and in neuromyelitis optica spectrum disorder (NMOSD). Thus, the aim of this study was to compare the choroid plexus volume in MS and NMOSD. METHODS: In this retrospective, cross-sectional study, patients were included by convenience sampling from 4 international MS centers. The choroid plexus of the lateral ventricles was segmented fully automatically on T1-weighted MRI sequences using a deep learning algorithm (Multi-Dimensional Gated Recurrent Units). Uni- and multivariable linear models were applied to investigate associations between the choroid plexus volume, clinically meaningful disease characteristics, and MRI parameters. RESULTS: We studied 180 patients with MS and 98 patients with NMOSD. In total, 94 healthy individuals and 47 patients with migraine served as controls. The choroid plexus volume was larger in MS (median 1,690 µL, interquartile range [IQR] 648 µL) than in NMOSD (median 1,403 µL, IQR 510 µL), healthy individuals (median 1,533 µL, IQR 570 µL), and patients with migraine (median 1,404 µL, IQR 524 µL; all p < 0.001), whereas there was no difference between NMOSD, migraine, and healthy controls. This was also true when adjusted for age, sex, and the intracranial volume. In contrast to NMOSD, the choroid plexus volume in MS was associated with the number of T2-weighted lesions in a linear model adjusted for age, sex, total intracranial volume, disease duration, relapses in the year before MRI, disease course, Expanded Disability Status Scale score, disease-modifying treatment, and treatment duration (beta 4.4; 95% CI 0.78-8.1; p = 0.018). DISCUSSION: This study supports an involvement of the choroid plexus in MS in contrast to NMOSD and provides clues to better understand the respective pathogenesis.