RESUMO
Stochastic molecular sensors based on resistive pulse nanopore modalities are envisioned as facile DNA sequencers. However, recent advances in nanotechnology fabrication have highlighted promising alternative detection mechanisms with higher sensitivity and potential single-base resolution. In this paper we present the novel self-aligned fabrication of a solid-state nanopore device with integrated transverse graphene-like carbon nanoelectrodes for polyelectrolyte molecular detection. The electrochemical transduction mechanism is characterized and found to result primarily from thermionic emission between the two transverse electrodes. Response of the nanopore to Lambda dsDNA and short (16-mer) ssDNA is demonstrated and distinguished.
Assuntos
Nanoporos , Análise de Sequência de DNA/métodos , Técnicas Biossensoriais , Carbono , Técnicas Eletroquímicas , Desenho de Equipamento , Microscopia Eletrônica de Varredura , Microscopia de Tunelamento , Nanoporos/ultraestrutura , Nanotecnologia , Nanofios/química , Nanofios/ultraestruturaRESUMO
The fabrication of carbon nanostructures by direct writing with a scanning force microscope is described. A conductive atomic force tip is used to collect carbon from a glassy carbon substrate and redeposit it onto a gold thin film under voltage control. The resulting patterns are examined with atomic force microscopy and Auger electron spectrometry. Writing of carbon lines with widths as small as 40 nm is demonstrated.