Detalhe da pesquisa
1.
Obtaining Functional Proteomics Insights From Thermal Proteome Profiling Through Optimized Melt Shift Calculation and Statistical Analysis With InflectSSP.
Mol Cell Proteomics;
22(9): 100630, 2023 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37562535
2.
Activation of Gcn2 by small molecules designed to be inhibitors.
J Biol Chem;
299(4): 104595, 2023 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36898579
3.
GCN2 is required to maintain core body temperature in mice during acute cold.
Am J Physiol Endocrinol Metab;
325(5): E624-E637, 2023 11 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37792040
4.
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.
PLoS Genet;
12(12): e1006518, 2016 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27977682
5.
Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii.
Antimicrob Agents Chemother;
62(11)2018 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30181373
6.
TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma.
Cancer Res;
84(8): 1286-1302, 2024 04 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38266162
7.
Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice.
bioRxiv;
2024 Jun 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38895427
8.
Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice.
J Clin Invest;
2024 Jun 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38889047
9.
Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response.
Antioxid Redox Signal;
39(4-6): 351-373, 2023 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36943285
10.
Activation of the integrated stress response (ISR) pathways in response to Ref-1 inhibition in human pancreatic cancer and its tumor microenvironment.
Front Med (Lausanne);
10: 1146115, 2023.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37181357
11.
PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.
Clin Cancer Res;
29(23): 4870-4882, 2023 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37733811
12.
A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells.
Clin Cancer Res;
29(24): 5155-5172, 2023 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37982738
13.
Asparagine bioavailability regulates the translation of MYC oncogene.
Oncogene;
41(44): 4855-4865, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36182969
14.
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
Elife;
112022 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36107759
15.
Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast.
J Biol Chem;
285(22): 16893-911, 2010 May 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20233714
16.
IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease.
J Immunol;
183(1): 568-77, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19542468
17.
How do tumours adapt to nutrient stress?
EMBO J;
29(12): 1946-7, 2010 Jun 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20551969
18.
Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.
Cell Death Dis;
9(3): 254, 2018 02 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29449538
19.
The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade.
Cell Rep;
22(11): 2978-2994, 2018 03 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29539425
20.
mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress.
Mol Cancer Res;
13(10): 1377-88, 2015 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26130148