Detalhe da pesquisa
1.
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system.
Cell Mol Biol Lett;
28(1): 97, 2023 Nov 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38030974
2.
Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models.
Int J Mol Sci;
24(13)2023 Jul 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37446212
3.
Unbalanced Expression of Glutathione Peroxidase 4 and Arachidonate 15-Lipoxygenase Affects Acrosome Reaction and In Vitro Fertilization.
Int J Mol Sci;
23(17)2022 Aug 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36077303
4.
Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15.
Int J Mol Sci;
22(6)2021 Mar 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33807076
5.
Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins.
Proc Natl Acad Sci U S A;
113(30): E4266-75, 2016 07 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27412860
6.
Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes.
Skin Pharmacol Physiol;
32(4): 192-200, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31096247
7.
Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1).
Biochim Biophys Acta Gen Subj;
1862(4): 866-876, 2018 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29366917
8.
Functional characterization of isolated RNA-binding domains of the GRSF1 protein.
Biochim Biophys Acta Gen Subj;
1862(4): 946-957, 2018 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29288125
9.
Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexaenoic acid.
Biochim Biophys Acta Mol Cell Biol Lipids;
1862(7): 666-675, 2017 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28400162
10.
Role of Arg403 for thermostability and catalytic activity of rabbit 12/15-lipoxygenase.
Biochim Biophys Acta;
1831(6): 1079-88, 2013 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23438511
11.
Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity.
Biochim Biophys Acta;
1811(12): 1001-10, 2011 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21875687
12.
Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?
Proteins;
80(3): 703-12, 2012 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22189720
13.
Structural and functional evaluation mammalian and plant lipoxygenases upon association with nanodics as membrane mimetics.
Biophys Chem;
288: 106855, 2022 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35849958
14.
The Reaction Specificity of Mammalian ALOX15 Orthologs is Changed During Late Primate Evolution and These Alterations Might Offer Evolutionary Advantages for Hominidae.
Front Cell Dev Biol;
10: 871585, 2022.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35531094
15.
Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging.
Biomedicines;
10(6)2022 Jun 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35740398
16.
Eicosanoid biosynthesis in marine mammals.
FEBS J;
288(4): 1387-1406, 2021 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32627384
17.
Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.
Biochim Biophys Acta Gen Subj;
1864(11): 129678, 2020 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32645484
18.
The lipoxygenase pathway of Tupaia belangeri representing Scandentia. Genomic multiplicity and functional characterization of the ALOX15 orthologs in the tree shrew.
Biochim Biophys Acta Mol Cell Biol Lipids;
1865(2): 158550, 2020 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31676437
19.
A role of Gln596 in fine-tuning mammalian ALOX15 specificity, protein stability and allosteric properties.
Biochim Biophys Acta Mol Cell Biol Lipids;
1865(7): 158680, 2020 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32151768
20.
Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.
Antioxid Redox Signal;
32(1): 1-17, 2020 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31642348