Detalhe da pesquisa
1.
Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group.
Chembiochem;
24(6): e202300006, 2023 03 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36602436
2.
Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein.
Molecules;
27(23)2022 Nov 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36500376
3.
Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction.
Molecules;
27(11)2022 May 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35684392
4.
PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action.
Int J Mol Sci;
22(21)2021 Oct 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34769226
5.
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions.
Angew Chem Int Ed Engl;
59(13): 5235-5241, 2020 03 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31944488
6.
Comparison of the Hydrogen Bond Interaction Dynamics in the Guanine and Cytosine Crystals: Ab Initio Molecular Dynamics and Spectroscopic Study.
J Phys Chem A;
123(50): 10757-10763, 2019 Dec 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31735026
7.
NMR fragment-based screening for development of the CD44-binding small molecules.
Bioorg Chem;
82: 284-289, 2019 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30396062
8.
Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists.
Beilstein J Org Chem;
15: 513-520, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30873235
9.
1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists.
RSC Med Chem;
15(4): 1210-1215, 2024 Apr 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38665826
10.
Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m-Terphenyl Derivatives.
ACS Med Chem Lett;
15(1): 36-44, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38229762
11.
Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction.
J Med Chem;
66(23): 15715-15727, 2023 12 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38039505
12.
Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments.
ACS Chem Biol;
17(9): 2655-2663, 2022 09 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36073782
13.
Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.
ACS Med Chem Lett;
12(5): 768-773, 2021 May 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34055224
14.
Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.
J Med Chem;
64(15): 11614-11636, 2021 08 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34313116
15.
A therapeutic patent overview of MDM2/X-targeted therapies (2014-2018).
Expert Opin Ther Pat;
29(3): 151-170, 2019 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30822185
16.
Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists.
Cancers (Basel);
11(7)2019 Jul 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31331108
17.
Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction.
Eur J Med Chem;
182: 111588, 2019 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31421630
18.
A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wt osteosarcoma cells.
FEBS J;
286(7): 1360-1374, 2019 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30715803
19.
Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction.
Eur J Med Chem;
126: 384-407, 2017 Jan 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27907876
20.
A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
ACS Chem Biol;
11(12): 3310-3318, 2016 12 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27709883