Detalhe da pesquisa
1.
Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection.
Gut;
72(7): 1385-1398, 2023 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36697207
2.
Safety, antiviral activity and pharmacokinetics of JNJ-64530440, a novel capsid assembly modulator, as 4 week monotherapy in treatment-naive patients with chronic hepatitis B virus infection.
J Antimicrob Chemother;
77(4): 1102-1110, 2022 03 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35040959
3.
JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection.
Gastroenterology;
159(2): 521-533.e9, 2020 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32343960
4.
Mean HBsAg decline at week 24 of PEG-IFN-based treatment predicts subsequent rate of HBsAg clearance - suggesting a valuable endpoint for early development HBV trials.
J Viral Hepat;
28(11): 1563-1569, 2021 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34435408
5.
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.
Gastroenterology;
156(5): 1392-1403.e7, 2019 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30625297
6.
Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
J Viral Hepat;
27(11): 1127-1137, 2020 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32579776
7.
A random effects model for the identification of differential splicing (REIDS) using exon and HTA arrays.
BMC Bioinformatics;
18(1): 273, 2017 May 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28545391
8.
A joint modeling approach for uncovering associations between gene expression, bioactivity and chemical structure in early drug discovery to guide lead selection and genomic biomarker development.
Stat Appl Genet Mol Biol;
15(4): 291-304, 2016 08 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27269248
9.
Identification of the minimum effective dose for normally distributed data using a Bayesian variable selection approach.
J Biopharm Stat;
27(6): 1073-1088, 2017.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28328286
10.
VirVarSeq: a low-frequency virus variant detection pipeline for Illumina sequencing using adaptive base-calling accuracy filtering.
Bioinformatics;
31(1): 94-101, 2015 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25178459
11.
High MIG (CXCL9) plasma levels favours response to peginterferon and ribavirin in HCV-infected patients regardless of DPP4 activity.
Liver Int;
36(3): 344-52, 2016 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26344576
12.
Gait characteristics and spatio-temporal variables of climbing in bonobos (Pan paniscus).
Am J Primatol;
78(11): 1165-1177, 2016 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27309794
13.
ViVaMBC: estimating viral sequence variation in complex populations from illumina deep-sequencing data using model-based clustering.
BMC Bioinformatics;
16: 59, 2015 Feb 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25887734
14.
Identification of in vitro and in vivo disconnects using transcriptomic data.
BMC Genomics;
16: 615, 2015 Aug 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26282683
15.
Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.
Chem Res Toxicol;
28(10): 1914-25, 2015 Oct 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26313431
16.
Gene filtering in the analysis of Illumina microarray experiments.
Stat Appl Genet Mol Biol;
11(2)2012 Jan 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22499694
17.
cn.FARMS: a latent variable model to detect copy number variations in microarray data with a low false discovery rate.
Nucleic Acids Res;
39(12): e79, 2011 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21486749
18.
Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study.
Antiviral Res;
216: 105660, 2023 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37385475
19.
Automated Spot Counting in Microbiology.
IEEE/ACM Trans Comput Biol Bioinform;
20(6): 3703-3714, 2023.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37725729
20.
The use of semiparametric mixed models to analyze PamChip(R) peptide array data: an application to an oncology experiment.
Bioinformatics;
27(20): 2859-65, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21846736