Detalhe da pesquisa
1.
Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
J Enzyme Inhib Med Chem;
38(1): 2231661, 2023 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37414563
2.
6-Benzyloxyphthalides as selective and reversible monoamine oxidase B inhibitors with antioxidant and anti-neuroinflammatory activities for Parkinson's disease treatment.
Bioorg Chem;
120: 105623, 2022 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35066317
3.
Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies.
Bioorg Chem;
127: 106007, 2022 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35849893
4.
Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer's disease.
J Enzyme Inhib Med Chem;
37(1): 792-816, 2022 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35193434
5.
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem;
35: 116074, 2021 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33640707
6.
Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer's disease.
Bioorg Chem;
112: 104879, 2021 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33915461
7.
Development of genistein-O-alkylamines derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Chem;
107: 104602, 2021 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33453647
8.
[Pharmacokinetics of eight active ingredients of Salviae Miltiorrhizae Radix et Rhizoma-Puerariae Lobatae Radix combination in rats].
Zhongguo Zhong Yao Za Zhi;
46(24): 6530-6541, 2021 Dec.
Artigo
em Zh
| MEDLINE
| ID: mdl-34994146
9.
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.
Bioorg Med Chem;
28(7): 115374, 2020 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32089390
10.
Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease.
Bioorg Med Chem;
28(8): 115400, 2020 04 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32146060
11.
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Bioorg Med Chem;
27(6): 991-1001, 2019 03 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30772129
12.
Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation.
Bioorg Chem;
84: 137-149, 2019 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30500523
13.
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorg Med Chem;
26(23-24): 6115-6127, 2018 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30470598
14.
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and ß-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorg Med Chem;
26(8): 1885-1895, 2018 05 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29500132
15.
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Bioorg Med Chem;
26(5): 1102-1115, 2018 03 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29409707
16.
Design, synthesis and evaluation of pterostilbene ß-amino alcohol derivatives as multifunctional agents for Alzheimer's disease treatment.
Bioorg Chem;
78: 298-306, 2018 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29625269
17.
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-ß aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Bioorg Med Chem Lett;
27(4): 718-722, 2017 02 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28131710
18.
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and ß-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorg Med Chem;
25(6): 1997-2009, 2017 03 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28237559
19.
Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease.
Bioorg Chem;
71: 305-314, 2017 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28267984
20.
Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-ß-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett;
26(8): 2035-9, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26947607