Comparison of CT images with average intensity projection, free breathing, and mid-ventilation for dose calculation in lung cancer.

The purpose of this study was to compare three computed tomography (CT) images under different conditions-average intensity projection (AIP), free breathing (FB), mid-ventilation (MidV)-used for radiotherapy contouring and planning in lung cancer patients. Two image sets derived from four-dimensional CT (4DCT) acquisition (AIP and MidV) and three-dimensional CT with FB were generated and used to plan for 29 lung cancer patients. Organs at risk (OARs) were delineated for each image. AIP images were calculated with 3D conformal radiotherapy (3DCRT) and intensity-modulated radiation therapy (IMRT). Planning with the same target coverage was applied to the FB and MidV image sets. Plans with small and large tumors were compared regarding OAR volumes, geometrical center differences in OARs, and dosimetric indices. A gamma index analysis was also performed to compare dose distributions. There were no significant differences (P > 0.05) in OAR volumes, the geometrical center differences, maximum and mean doses of the OARs between both tumor sizes. For 3DCRT, the gamma analysis results indicated an acceptable dose distribution agreement of 95% with 2%/2 mm criteria. Although, the gamma index results show distinct contrast of dose distribution outside the planning target volume (PTV) in IMRT, but within the PTV, it was acceptable. All three images could be used for OAR delineation and dose calculation in lung cancer. AIP image sets seemed to be suitable for dose calculation while patient movement between series acquisition of FB images should be considered when defining target volumes on 4DCT images.

Correction: Suwanbut et al. Assessment of Fetal Dose and Health Effect to the Fetus from Breast Cancer Radiotherapy during Pregnancy. Life 2022, 12, 84.

In the original publication [...].

Assessment of Fetal Dose and Health Effect to the Fetus from Breast Cancer Radiotherapy during Pregnancy.

Decision for radiotherapy during the first trimester of pregnancy may occur, as patients may not realize their pregnancy at the very early stage. Since radiation dose can affect fetal development, the aim of this study was to evaluate fetal dose and associated deterministic effects and risks to the fetus from breast cancer radiotherapy of an 8-week pregnant patient. PHITS (Particle and Heavy Ion Transport code System) Monte Carlo simulation and the J-45 computational pregnancy phantom were used to simulate breast cancer radiotherapy from a 6 MV TrueBeam linear accelerator using the three dimensional-conformal radiotherapy (3D-CRT) technique with a prescribed dose to the planning target volume (PTV) of 50 Gy. Once the fetal dose was evaluated, the occurrence of the deterministic effects and risks for developing stochastic effects in the fetus were assessed using the recommendations of NCRP Report No. 174, AAPM Report No. 50, and ICRP Publication 84. The fetal dose was evaluated to be 3.37 ± 2.66 mGy, suggesting that the fetus was expected to have no additional deterministic effects, while the risks for developing cancer and malfunctions were similar to that expected from exposure to background radiation. The comparison with the other studies showed that accurate consideration of fetal position and size was important for dose determination in the fetus, especially at the early pregnancy stage when the fetus is very small.

Automating QA analysis for a six-degree-of-freedom (6DOF) couch using image displacement and an accelerometer sensor.

The purpose of this study is to develop an approach for automating quality assurance (QA) analysis for a six-degree-of-freedom (6DOF) couch using image displacement and an accelerometer sensor. A cubic phantom was fabricated using 3D printing and the accelerometer sensor was embedded in the phantom to measure the couch in the pitch and roll directions. The accuracy and reliability of image displacement and the accelerometer sensor were investigated prior to their practical use for 6DOF couch QA. Image displacement performance had an accuracy and reliability of 0.026 ± 0.026 mm for the translation direction and 0.021 ± 0.016° for the rotation direction. Accelerometer sensor performance had an accuracy and reliability of 0.023 ± 0.018° for pitch rotation and 0.051 ± 0.024° for roll rotation. Automating QA analysis was used to perform 6DOF couch QA, and the couch position errors measured using image displacement were less than 0.99 mm, 0.91 mm, 0.82 mm for the vertical, longitudinal, lateral translation in range between ±20 mm, and 0.07°, 0.23°, and 0.2° for pitch, roll, and yaw rotation in range between ±3° whereas the couch position errors measured using the accelerometer sensor were less than 0.1° and 0.19° for the pitch and roll rotation in range between ±3°.

In vivo whole body dosimetry measurement technique of total body irradiation: a 12-year retrospective study result from one institute in Thailand.

OBJECTIVE: The main problem of total body irradiation (TBI) is how to maintain radiation dose homogeneity throughout the body during a treatment course. The simple set up treatment with non-complicated in vivo dosimetry measurement technique is the ideal method to solve this problem. For this reason, the authors have reported the results of in vivo dosimetry measurement method to prove the reliability of dose distribution from the authors' TBI technique. MATERIAL AND METHOD: The authors reviewed the data of dose measurement record from 53 patients' treatment files to report the uniformity of absorbed in vivo dose distribution throughout the whole body from TBI with semiconductor detectors and ionization chamber with the accepted homogeneity within +/- 10% of the prescribed dose. The result was reported in the term of mean and standard deviation of absorbed dose difference from the prescribed dose. RESULTS: The uniformity of radiation dose distribution throughout the whole body of all patients calculated from semiconductors was accepted with mean difference value of -3.2 +/- 2.5% from the prescribed dose and the difference of mean absorbed dose value at midline point between semiconductor and ionization chamber was 4 +/- 3.3%. CONCLUSION: This TBI dosimetry measurement technique has been proved to exhibit the reliability of dose homogeneity throughout the whole body within the accepted value. This could be applied for use at any institute that has some limitation in resources and small treatment room.

Dosimetric Effect of Jaw Tracking in Volumetric-Modulated Arc Therapy.

The aim of this study was to investigate the potential of jaw tracking with the volumetric-modulated arc therapy (VMAT) to reduce the normal tissue dose. Plans of nasopharynx, lung, and prostate cancers (10 plans for each) were used to perform VMAT with and without jaw tracking. The dose reduction was evaluated in terms of organ doses and integral doses. Organ-dose reduction with jaw tracking was statistically significant in the volume receiving a dose of 5 Gy (V5) of bladder, rectum, and lung, the volume receiving a dose of 10 Gy (V10) of bladder, rectum, and lung, and the mean dose of lung (P < 0.05). Integral-dose reduction with jaw tracking was statistically significant in almost all the treatment plans (P < 0.05). For organ-dose reduction, jaw tracking in VMAT plan was effective in reducing V5 and V10. For integral-dose reduction, jaw tracking in VMAT plan is an efficient method for decreasing V5.

Posterior kV-CBCT scanning of the head and neck region minimizes doses to critical organs with sustained image quality.

We evaluated the absorbed dose to critical organs, as well as the image quality, at different partial angles in kV-CBCT (Cone Beam Computed Tomography) scanning of the head and neck region. CBCT images of phantom from a 200° rotation were performed by using three different scanning paths, anterior, posterior, and right lateral with Catphan504 and RANDO phantoms. Critical organ dose was measured using TLD 100H in the RANDO phantom. The image quality of those phantoms was evaluated, using HU uniformity, HU linearity, contrast-to-noise ratio, low contrast visibility and spatial resolution with the Catphan504 dataset; and 5-point grading scales for the RANDO phantom dataset by five radiation oncologists. The image qualities from Catphan504 and RANDO phantom of every scanning path were comparable, with no statistically significant difference (p ≥ 0.05). However, there was a significant difference in the critical organ dose in all paths (p < 0.05), depending on the critical organ location and the scanning direction. Scanning directions show no effects on the image quality. Differences in absorbed dose to critical organs should were evaluated. The posterior scanning path for the CBCT was deemed preferable due because of considerably lower doses to several critical organs of the head and neck region.