Detalhe da pesquisa
1.
Discovery and SAR of 4-aminopyrrolidine-2-carboxylic acid correctors of CFTR for the treatment of cystic fibrosis.
Bioorg Med Chem Lett;
72: 128843, 2022 09 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35688367
2.
Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222.
J Pharmacol Exp Ther;
372(1): 107-118, 2020 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31732698
3.
Utilization of 18F-Fluorodeoxyglucose-Positron Emission Tomography To Understand the Mechanism of Nicotinamide Phosphoribosyltransferase Inhibitors In Vivo.
J Pharmacol Exp Ther;
371(3): 583-589, 2019 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31562200
4.
Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.
Biochem Biophys Res Commun;
491(3): 681-686, 2017 09 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28756225
5.
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett;
27(15): 3317-3325, 2017 08 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28610984
6.
Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells.
BMC Cancer;
14: 430, 2014 Jun 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24927813
7.
Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling.
Mol Cancer Ther;
23(1): 35-46, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37735104
8.
Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
J Pharmacol Exp Ther;
343(3): 617-27, 2012 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22935731
9.
Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs.
Bioorg Med Chem Lett;
22(2): 1091-4, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22178557
10.
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.
Bioorg Med Chem Lett;
22(14): 4750-5, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22695126
11.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Bioorg Med Chem Lett;
22(9): 3208-12, 2012 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22465635
12.
Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors.
Bioorg Med Chem;
20(13): 4088-97, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22664188
13.
Determining the Research Priorities for Adult Primary Brain Tumours in Australia and New Zealand: A Delphi Study with Consumers, Health Professionals, and Researchers.
Curr Oncol;
29(12): 9928-9955, 2022 12 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36547195
14.
Glutamate-cysteine ligase catalytic subunit as a therapeutic target in acute myeloid leukemia and solid tumors.
Am J Cancer Res;
11(6): 2911-2927, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34249435
15.
The brain tumor not-for-profit and charity experience of COVID-19: reacting and adjusting to an unprecedented global pandemic in the 21st century.
Neurooncol Adv;
3(1): vdaa166, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33501430
16.
Brain tumors and COVID-19: the patient and caregiver experience.
Neurooncol Adv;
2(1): vdaa104, 2020.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32989433
17.
Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.
ACS Med Chem Lett;
10(11): 1543-1548, 2019 Nov 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31749908
18.
Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.
J Med Chem;
61(4): 1436-1449, 2018 02 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29251932
19.
Donated chemical probes for open science.
Elife;
72018 04 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29676732
20.
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol Cancer Ther;
16(7): 1236-1245, 2017 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28468779