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1.
Pediatr Blood Cancer ; 71(8): e31120, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38825724

RESUMO

The EPICO (Spanish general registry of COVID-19 in children)-SEHOP (Spanish Society of Pediatric Hematology and Oncology) platform gathers data from children with SARS-CoV-2 in Spain, allowing comparison between children with cancer or allogeneic hematopoietic stem cell transplantation (alloHSCT) and those without. The infection is milder in the cancer/alloHSCT group than in children without comorbidities (7.1% vs. 14.7%), except in children with recent alloHSCT (less than 300 days), of which 35.7% experienced severe COVID-19. These data have been shared with the SEHOP members to support treatment and isolation policies akin to those for children without cancer, except for those with recent alloHSCT or additional comorbidities. This highlights the collaborative registries potential in managing pandemic emergencies.


Assuntos
COVID-19 , Comorbidade , Transplante de Células-Tronco Hematopoéticas , Neoplasias , SARS-CoV-2 , Humanos , COVID-19/epidemiologia , COVID-19/complicações , Criança , Masculino , Adolescente , Feminino , Pré-Escolar , Fatores de Risco , Neoplasias/epidemiologia , Neoplasias/terapia , Lactente , Espanha/epidemiologia , Sistema de Registros , Transplante Homólogo
2.
Pediatr Dev Pathol ; : 10935266241249344, 2024 May 19.
Artigo em Inglês | MEDLINE | ID: mdl-38762770

RESUMO

Sarcomas characterized by BCOR gene alterations, are a distinct clinico-pathological group of high-grade tumors, that represent 5% of small round cell tumors without EWSR or FUS fusion. Diverse genetic alterations characterize this group, including BCOR-CCNB3 gene fusion being the most common alteration and less frequently internal tandem duplications (ITDs). We present a compelling case of a 3-year-old girl diagnosed with a high-grade nasoethmoidal sarcoma exhibiting BCOR-ITD. The diagnostic process illustrates the histological and immunophenotypic spectrum, requiring an extensive immunohistochemical panel and diverse molecular tests for accurate classification. Additionally, this case highlights the challenges in detecting BCOR-ITDs using different NGS panels, advocating for alternative molecular approaches. Our patient after 10 months since diagnosis is alive with progressive disease. This emphasizes the urgency for ongoing research to refine diagnostic methods and develop effective therapeutic strategies for these rare and aggressive tumors.

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