Different epidemiological profiles in patients with Zika and dengue infection in Tapachula, Chiapas in Mexico (2016-2018): an observational, prospective cohort study.

BACKGROUND: The introduction of Zika and chikungunya to dengue hyperendemic regions increased interest in better understanding characteristics of these infections. We conducted a cohort study in Mexico to evaluate the natural history of Zika infection. We describe here the frequency of Zika, chikungunya and dengue virus infections immediately after Zika introduction in Mexico, and baseline characteristics of participants for each type of infection. METHODS: Prospective, observational cohort evaluating the natural history of Zika virus infection in the Mexico-Guatemala border area. Patients with fever, rash or both, meeting the modified criteria of PAHO for probable Zika cases were enrolled (June 2016-July 2018) and followed-up for 6 months. We collected data on sociodemographic, environmental exposure, clinical and laboratory characteristics. Diagnosis was established based on viral RNA identification in serum and urine samples using RT-PCR for Zika, chikungunya, and dengue. We describe the baseline sociodemographic and environmental exposure characteristics of participants according to diagnosis, and the frequency of these infections over a two-year period immediately after Zika introduction in Mexico. RESULTS: We enrolled 427 participants. Most patients (n = 307, 65.7%) had an acute illness episode with no identified pathogen (UIE), 37 (8%) Zika, 82 (17.6%) dengue, and 1 (0.2%) chikungunya. In 2016 Zika predominated, declined in 2017 and disappeared in 2018; while dengue increased after 2017. Patients with dengue were more likely to be men, younger, and with lower education than those with Zika and UIE. They also reported closer contact with water sources, and with other people diagnosed with dengue. Participants with Zika reported sexual exposure more frequently than people with dengue and UIE. Zika was more likely to be identified in urine while dengue was more likely found in blood in the first seven days of symptoms; but PCR results for both were similar at day 7-14 after symptom onset. CONCLUSIONS: During the first 2 years of Zika introduction to this dengue hyper-endemic region, frequency of Zika peaked and fell over a two-year period; while dengue progressively increased with a predominance in 2018. Different epidemiologic patterns between Zika, dengue and UIE were observed. Trial registration Clinical.Trials.gov (NCT02831699).

Implementation of Evidence-Based HIV Interventions for Gay, Bisexual, and Other Men Who Have Sex with Men.

The Centers for Disease Control and Prevention provides trainings to support implementation of five evidence-based HIV prevention interventions (EBIs) for men who have sex with men (MSM): d-up: Defend Yourself!; Many Men, Many Voices; Mpowerment; Personalized Cognitive Counseling; and Popular Opinion Leader. We evaluated trainees' implementation of these EBIs and, using multivariable logistic regression, examined factors associated with implementation. Approximately 43% of trainees had implemented the EBIs for which they received training. Implementation was associated with working in community-based organizations (vs. health departments or other settings); acquiring training for Mpowerment or Popular Opinion Leader (vs. Personalized Cognitive Counseling); having ≥3 funding sources (vs. one); and having (vs. not having) sufficient time and necessary EBI resources. Findings suggest that implementation may vary by trainee characteristics, especially those related to employment setting, EBI training, funding, and perceived implementation barriers. Efforts that address these factors may help to improve EBI implementation among trainees.

Comparison of clinical characteristics of Zika and dengue symptomatic infections and other acute illnesses of unidentified origin in Mexico.

BACKGROUND: Our purpose was to provide a detailed clinical description, of symptoms and laboratory abnormalities, and temporality in patients with confirmed Zika and dengue infections, and other acute illnesses of unidentified origin (AIUO). METHODS/ PRINCIPAL FINDINGS: This was a two-year, multicenter, observational, prospective, cohort study. We collected data from patients meeting the Pan American Health Organization's modified case-definition criteria for probable Zika infection. We identified Zika, dengue chikungunya by RT-PCR in serum and urine. We compared characteristics between patients with confirmed Zika and dengue infections, Zika and AIUO, and Dengue and AIUO at baseline, Days 3,7,28 and 180 of follow-up. Most episodes (67%) consistent with the PAHO definition of probable Zika could not be confirmed as due to any flavivirus and classified as Acute Illnesses of Unidentified Origin (AIUO). Infections by Zika and dengue accounted for 8.4% and 16% of episodes. Dengue patients presented with fever, generalized non-macular rash, arthralgia, and petechiae more frequently than patients with Zika during the first 10 days of symptoms. Dengue patients presented with more laboratory abnormalities (lower neutrophils, lymphocytosis, thrombocytopenia and abnormal liver function tests), with thrombocytopenia lasting for 28 days. Zika patients had conjunctivitis, photophobia and localized macular rash more frequently than others. Few differences persisted longer than 10 days after symptoms initiation: conjunctivitis in Zika infections, and self-reported rash and petechia in dengue infections. CONCLUSIONS: Our study helps characterize the variety and duration of clinical features in patients with Zika, dengue and AIUO. The lack of diagnosis in most patients points to need for better diagnostics to assist clinicians in making specific etiologic diagnoses.

[Progress and pending issues in the Latin American agenda for tobacco control]. / Avances y puntos pendientes en la agenda latinoamericana para el control del tabaco.

Projections based on the most recent report on the Global Burden of Disease show that the observed increase in smoking prevalence in middle and low income countries will contribute to the increase of the number of deaths due to cardiovascular diseases, chronic obstructive pulmonary diseases, and some cancers. The World Health Organization (WHO) Framework Convention on Tobacco Control recommends a group of actions to curb the tobacco epidemic. This is a review paper based on the most recent MPOWER report and also included in this review are some of the most recent tobacco control measures implemented during 2009 and 2010. We conclude that most Latin American countries have achieved significant progress in tobacco control in recent years. However, when comparing the current situation against the WHO recommendations we realized that for most countries there is still work to be done. If current smoking prevalence among teenagers remains unchanged, there will be a significant increase in the number of premature deaths attributable to tobacco consumption in future decades.

[Monitoring strategy for control of tobacco in Mexico: advertising, promotion and sponsorship, packaging and labeling]. / Estrategia de vigilancia para el control del tabaco en México: publicidad, promoción y patrocinio, empaque y etiquetado.

OBJECTIVE: To describe strategies used in the publicity, marketing, and sale, of tobacco products in 12 cities in Mexico. MATERIAL AND METHODS: Tobacco products points of sale (POS) were identified within a 500 m radius of Global Youth Tobacco Survey (2005-2006) schools. We used observational surveys and an online Geographic Information System (GIS). RESULTS: In the 257 schools visited, we found, on average, 8.3 stores and 5 street vendors around each of them. Forty-four percent of the stores had interior tobacco publicity, 8.3% had tobacco products at children's eye level, 6.5% had some promotion, 33.6% had a no selling to minors sign, and 44.4% of stores and 58.8% of street vendors sold single cigarettes. CONCLUSIONS: Tobacco products are largely publicized and marketed around schools. There is no compliance of tobacco control legislation in regards to selling to minors and single cigarettes. It is necessary to implement a surveillance system to monitor strategies for tobacco control and the tobacco industry.

Comparison of Rates of Hospitalization Between Single and Dual Virus Detection in a Mexican Cohort of Children and Adults With Influenza-Like Illness.

BACKGROUND: Molecular detection methods allow for the simultaneous detection of several infectious agents. This study assesses whether co-infection with 2 viruses as compared with 1 is associated with increased hospitalization in those with acute respiratory infections. METHODS: We prospectively enrolled a cohort of pediatric and adult participants with influenza-like illness during 2010-2014 in Mexico. Clinical information and respiratory samples were collected at enrollment. Respiratory viruses were detected with multiplex polymerase chain reaction (PCR) and influenza-specific reverse transcription PCR assays. Participants were followed for 14 and 28 days after inclusion. Severity of disease, as measured by hospitalization with acute respiratory infections, was compared between single and dual viral infections. RESULTS: Among 5662 participants in the study, either 1 (n = 3285) or 2 (n = 641) viruses were detected in 3926 participants. Rhinovirus (n = 1433), influenza (n = 888), and coronaviruses (n = 703) were the most frequently detected viruses (either alone or in co-infection). Bocavirus, respiratory syncytial virus (RSV), metapneumovirus, and rhinovirus cases were hospitalized more often than other viruses. Bocavirus+rhinovirus cases were hospitalized more often than those with rhinovirus alone (but not bocavirus alone). RSV cases were more likely to be hospitalized than cases with co-infections of RSV and parainfluenza virus or coronavirus. Metapneumovirus cases were hospitalized more often than those co-infected with metapneumovirus+coronavirus. CONCLUSIONS: In this study, detection of 2 viruses did not significantly increase hospitalizations compared with single virus infections. Larger studies will allow for distinguishing between sequential and simultaneous infection and for a better understanding of the role of each virus during the evolution of acute respiratory episodes.

"Differential risk of hospitalization among single virus infections causing influenza-like illnesses".

BACKGROUND: Acute respiratory infections are a major cause of morbidity in children and are often caused by viruses. However, the relative severity of illness associated with different viruses is unclear. The objective of this study was to evaluate the risk of hospitalization from different viruses in children presenting with an influenza-like illness (ILI). METHODS: Data from children 5 years old or younger participating in an ILI natural history study from April 2010 to March 2014 was analyzed. The adjusted odds ratio for hospitalization was estimated in children with infections caused by respiratory syncytial virus (RSV), metapneumovirus, bocavirus, parainfluenza viruses, rhinovirus/enterovirus, coronavirus, adenovirus, and influenza. RESULTS: A total of 1486 children (408 outpatients and 1078 inpatients) were included in this analysis. At least one virus was detected in 1227 (82.6%) patients. The most frequent viruses detected as single pathogens were RSV (n = 286), rhinovirus/enterovirus (n = 251), parainfluenza viruses (n = 104), and influenza A or B (n = 99). After controlling for potential confounders (age, sex, recruitment site, days from symptom onset to enrollment, and underlying illnesses), children with RSV and metapneumovirus infections showed a greater likelihood of hospitalization than those infected by parainfluenza viruses (OR 2.7 and 1.9, respectively), rhinovirus/enterovirus (OR 3.1 and 2.1, respectively), coronaviruses (OR 4.9 and 3.4, respectively), adenovirus (OR 4.6 and 3.2, respectively), and influenza (OR 6.3 and 4.4, respectively). CONCLUSIONS: Children presenting with ILI caused by RSV and metapneumovirus were at greatest risk for hospitalization, while children with rhinovirus/enterovirus, parainfluenza, coronavirus, adenovirus, and influenza were at lower risk of hospitalization.

Linking Global Youth Tobacco Survey (GYTS) data to the WHO Framework Convention on Tobacco Control (FCTC): the case for Mexico.

BACKGROUND: The adoption of the World Health Organization Framework Convention on Tobacco Control (WHO FCTC) in 2004 marked a critical achievement in efforts to stem the tobacco epidemic in Mexico. The Global Youth Tobacco Survey (GYTS) findings are useful for evaluating achievement of FCTC articles and designing tobacco control programs. OBJECTIVE: To use data from the GYTS conducted in 21 Mexican cities between 2000 and 2005 to monitor Articles in the WHO FCTC. METHODS: The GYTS uses a two-stage cluster sample survey design that produces representative samples of students aged 13-15 years enrolled in public, private and technical schools. The survey was undertaken at 542 schools in 21 cities. The GYTS surveyed 43,950 students during 2000-2005. RESULTS: The current smoking rate ranged from 10.7% to 29.4%. Among never smokers, susceptibility to initiate smoking ranged from 20.2% to 34.4%. Among current smokers, the percentage who bought their cigarettes in a store was above 40% in 6 cities, but significantly declined over five years in the only city with two assessments (Monterrey). Exposure to secondhand smoke in public places was greater than 50% in 15 of the 21 cities. Over 80% of students in all 21 cities reported that they saw of advertisements for cigarettes on billboards. CONCLUSION: Using determinants measured by GYTS in Mexico, the government can monitor the impact of enforcing various provisions of the National Health Law and the progress made in achieving the goals of the WHO FCTC and the Regional strategy. When these goals are met, tobacco consumption and exposure in Mexico will have declined substantially.

Promoting the effective translation of the framework convention on tobacco control: a case study of challenges and opportunities for strategic communications in Mexico.

The World Health Organization Framework Convention on Tobacco Control (WHO-FCTC) promotes the implementation of best-practices tobacco control policies at a global scale. This article describes features of the sociocultural and political-economic context of Mexico that pose challenges and opportunities to the effective translation of WHO-FCTC policies there. It also considers how strategic communication efforts may advance these policies by framing their arguments in ways that resonate with prevalent values, understandings, and concerns. A focus on a smoke-free policy illustrates barriers to policy compliance, including how similar issues have been overcome among Latino populations in California. Overall, this article aims to lay the foundation for comparative research from policy uptake to impact so that the scientific evidence base on tobacco control policies includes examination of how context moderates this process.

[Laws that ban smoking in indoor places in Mexico]. / Leyes que prohíben fumar en espacios cerrados en México.

Recently Mexico passed federal and state-level laws banning smoking in indoor spaces. These actions are totally in accordance with measures proposed in the WHO-FCTCs article 8, ratified by Mexico in 2004. This essay reviews scientific evidence that secondhand smoke causes both chronic and acute diseases among non smokers, children and adults. There is no safe level of exposure to secondhand smoke, so the only effective intervention to protect Mexican people from such harmful exposure is by promoting 100% smoke free indoor air, as the two new laws do. Total banning of smoking is associated with reduction in smoking prevalence, amount of cigarette smoked per day, and an increase in cessation rates. Reductions in acute respiratory symptoms and hospitalization of acute myocardial infarction have been also reported. Well documented examples show that main tobacco industry arguments against smoke free policy: negative economic impact and lack of support from the public, are unjustified. These two laws strengthen the Mexican tobacco control program. Next steps include their implementation, evaluation, enforcement of compliance and encouragement for similar laws at state level.

Costs of medical care for acute myocardial infarction attributable to tobacco consumption.

BACKGROUND: Tobacco consumption is the principal modifiable risk factor causally associated with acute myocardial infarction (AMI). AMI has been an increasing and important cause of death in Mexico since 1980. METHODS: To estimate the direct health care costs of AMI, we carried out a cost of illness (COI) analysis, using data derived from an expert panel consensus and from medical chart review. We used the smoking attributable fraction (SAF) estimates to derive costs of tobacco consumption. We also estimated the benefits of a "Smoke-free Workplace" tobacco control policy in terms of avoidable deaths and health care costs savings. RESULTS: We estimated an annual average costs of 6,420 US dollars and 9,216 US dollars for non-ST segment elevation AMI (NSTEMI) and ST segment elevation AMI (STEMI), respectively. The total annual health care costs estimated for incident AMI for the IMSS state-level division of Morelos reached 2.9 million US dollars, of which 1.6 million US dollars was directly attributed to tobacco consumption. CONCLUSIONS: Our results confirm the high costs associated with smoking and show the potential benefits resulting from a tobacco control policy. Our estimates are only applicable to social security in the state-level division of Morelos and more likely represent a lower boundary of the total costs of cardiovascular diseases attributed to tobacco, because we based the costs estimation on incident cases, and we did not take into consideration the costs derived from prevalent cases, indirect costs or other intangibles.

Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers.

The exposure-response for hexavalent chromium (Cr(VI))-induced lung cancer among workers of the Painesville Ohio chromate production facility has been used internationally for quantitative risk assessment of environmental and occupational exposures to airborne Cr(VI). We updated the mortality of 714 Painesville workers (including 198 short-term workers) through December 2011, reconstructed exposures, and conducted exposure-response modeling using Poisson and Cox regressions to provide quantitative lung cancer risk estimates. The average length of follow-up was 34.4 years with 24,535 person-years at risk. Lung cancer was significantly increased for the cohort (standardized mortality ratio (SMR)=186; 95% confidence interval (CI) 145-228), for those hired before 1959, those with >30-year tenure, and those with cumulative exposure >1.41 mg/m(3)-years or highest monthly exposures >0.26 mg/m(3). Of the models assessed, the linear Cox model with unlagged cumulative exposure provided the best fit and was preferred. Smoking and age at hire were also significant predictors of lung cancer mortality. Adjusting for these variables, the occupational unit risk was 0.00166 (95% CI 0.000713-0.00349), and the environmental unit risk was 0.00832 (95% CI 0.00359-0.0174), which are 20% and 15% lower, respectively, than values developed in a previous study of this cohort.

Consumption of higher numbers of cigarettes in Mexican youth: the importance of social permissiveness of smoking.

This study sought to assess the relationship between level of cigarette smoking and social factors indicating permissiveness of smoking among youth. This was a school-based cross-sectional questionnaire study carried out in a random sample of students (n=13,293, 11-24 years) at public schools in Morelos, Mexico. Chi2 test and multiple logistic regression analysis were used to evaluate correlates of level of smoking (> or < or = 5 cigarettes/day). There is a rising trend in smoking among Mexican in-school youth, a tendency towards smoking initiation at increasingly younger ages and a decrease in the gender gap regarding smoking. When young people smoked at home, at school and outside, they were over fives times as likely to smoke >5 cigarettes/day. Prevention of smoking among Mexican adolescents should emphasize smoke-free schools, no smoking policies in the community and parental anti-tobacco education.

Susceptibility to smoking among adolescents and its implications for Mexico's tobacco control programs. Analysis of the Global Youth Tobacco Survey 2003-2004 and 2006-2007.

Smoking prevention efforts should either prevent target groups from becoming susceptible to smoking or prevent susceptible adolescents from progressing to becoming regular smokers. To describe the prevalence of susceptibility to smoking among never smoker students from cities that applied the GYTS in 2003 and 2006. The GYTS uses a two-stage cluster sample survey design that produces representative samples of students aged 12-15 years enrolled in public, private, and technical schools. The survey was undertaken at 399 schools in 9 cities. The GYTS surveyed 33,297 students during the academic years 2003-04 and 2006-07. Among never smokers, about 25% are likely to initiate smoking in the next 12 months. There are no differences in susceptibility to smoking by gender. When comparing results from 2003 and 2006, the susceptibility index has not changed, but for one city. The GYTS results are useful for monitoring susceptibility to smoking among adolescents and provide evidence for strengthening the efforts of tobacco control programs in Mexico.

[Before and after the Framework Convention on Tobacco Control in Mexico: a comparison from the 2003 and 2006 Global Youth Tobacco Survey]. / Antes y después del Convenio Marco en México: una comparación desde la Encuesta sobre Tabaquismo en Jóvenes 2003 y 2006.

OBJECTIVE: The aim of this paper is to present findings from the GYTS on current cigarette smoking and other tobacco epidemic indicators. MATERIAL AND METHODS: The GYTS uses a two-stage cluster sample survey design that produces representative samples of students aged 12 to 15 years enrolled in public, private and technical schools. The survey was undertaken in 2003 and 2006 at 399 schools in nine cities. The GYTS surveyed 33 297 students. Point prevalence, differences of proportions and adjusted odds ratio were estimated. RESULTS: The overall rate for current smoking in 30 days preceding the survey is 24.9% (95% CI, 22.5-27.3). Among never smokers, 28% are likely to initiate smoking next year. As compared to the previous survey in 2003, there is not a reduction in cigarette smoking or exposure to secondhand smoke. Cessation rates have not changed and advertisements and access by minors to tobacco products are still unresolved problems. However, tobacco related materials have significantly been added to school curricula. National estimates are presented, as well as city level estimates. CONCLUSION: Two years after FCTC ratification, there is no major improvement in critical areas of tobacco control in Mexico; particularly, there is no evidence of reduction in cigarette smoking among students in secondary schools.

[Involuntary exposure to tobacco smoke in public places in Mexico City]. / Exposición involuntaria al humo de tabaco en lugares públicos de la Ciudad de México.

OBJECTIVE: Mexican legislation considers many public places as smoke-free spaces. However, no environmental tobacco smoke exposure assessment studies exist to evaluate compliance with governmental regulations and to identify opportunities for tobacco control. The main objective of this study is to quantify airborne nicotine concentrations in public places in Mexico City. MATERIAL AND METHODS: During March 2004, nicotine passive monitors were allocated in a hospital, two schools, a public office building, an airport, seven restaurants, and three bars following a common protocol applied in other Latin American countries. Monitors were analyzed at the Johns Hopkins University, extracting the nicotine and quantifying it using nitrogen selective gas chromatography. Median concentrations of environmental nicotine were estimated by type of place and smoking restriction. RESULTS: Airborne nicotine was detected in all public places. The highest concentrations were observed in bars (6.01 microg/m3), restaurants (0.69 microg/m3), airport (0.21 microg/m3), and public offices (0.10 microg/m3). Nicotine exposure concentrations are similar to those previously observed in other capital cities of Latin America. CONCLUSIONS: Nicotine levels in the airport and public offices reflect the lack of compliance with mandatory non-smoking official regulations in Mexico. High nicotine concentrations in bars and restaurants provide evidence for the need to advance smoke-free legislative action in these public and work places.

Secondhand smoke exposure in Mexican discotheques.

This study describes the impact of exposure to secondhand smoke for subjects who spend time in a discotheque, by comparing within-subject baseline and postexposure urinary cotinine levels. A total of 100 nonsmoking volunteers from a central region of Mexico provided a urine sample before entering a discotheque and another sample an average of 6 hr after the end of exposure. Concentrations of cotinine and its metabolite, trans-3'-hydroxycotinine, were measured in the urine by liquid chromatography-mass spectrometry. In females the average preexposure level of urinary cotinine was 2.2 ng/ml, and the average postexposure level was significantly higher, at 15.7 ng/ml. In males the average preexposure level of cotinine was 3.7 ng/ml, compared with 49.1 ng/ml in the postexposure assessment. The highest postexposure values were found in men younger than 22 years old with a value of 469.5 ng/ml. Exposure to secondhand smoke is a serious health risk. Our findings are important given that many of our subjects were exposed to substantial amounts of secondhand smoke in discotheques, as evidenced by the high urinary cotinine and 3'-hydroxycotinine concentrations. These findings support the need to prohibit smoking in discotheques to protect nonsmokers' health.

[Main challenges of the framework convention on tobacco control in Mexico: a surveillance report from the Global Youth Tobacco Survey]. / Los retos del convenio marco para el control del tabaco en México: un diagnóstico a partir de la Encuesta sobre Tabaquismo en Jóvenes.

OBJECTIVE: This study presents findings from the Global Youth Tobacco Survey (GYTS) regarding current cigarette smoking and other tobacco epidemic indicators. MATERIAL AND METHODS: The GYTS used a two-stage cluster sample survey to generate representative samples of students aged 12 to 15 years old enrolled in public, private and technical schools. The survey was undertaken at 492 schools in 21 cities. The GYTS surveyed 42,024 students between the years 2003 and 2005. A logistic regression model was applied and crude and adjusted odds ratios were estimated. RESULTS: The overall current smoking rate during the 30 days preceding the survey was 19.96% (95% CI 18.1-21.8). Among those who never smoked, 25% were likely to begin smoking in the following year. Sixty percent of current smokers who bought their cigarettes in stores were not refused purchase because of their age. Exposure to advertising in outside areas was 86 and 54% of students reported to have been exposed to smoke in public places. CONCLUSION: Comprehensive tobacco control programs should prevent access by minors to cigarettes, make it more difficult to smoke, and prohibit all forms of tobacco advertising. In addition, options should be provided for those who wish to quit smoking and adolescents and their families should be educated with respect to the dangers of smoking.

Avances y puntos pendientes en la agenda latinoamericana para el control del tabaco / Progress and pending issues in the Latin American agenda for tobacco control

El estudio de la Carga Mundial de la Enfermedad proyecta que el incremento en la prevalencia de fumadores en países de ingresos medios y bajos contribuirá a incrementar las muertes cardiovasculares, por enfermedad pulmonar obstructiva crónica y algunos cánceres. Para reducir estas consecuencias del tabaquismo, la Organización Mundial de la Salud (OMS) recomienda un conjunto de acciones reunidas en el Convenio Marco para el Control del Tabaco (CMCT) y los informes MPOWER. En este artículo se revisó el más reciente de estos informes y sintetizamos las principales intervenciones que estaban vigentes en los países latinoamericanos y también revisamos algunas medidas implementadas durante 2009 y 2010. En los últimos años se ha avanzado considerablemente en materia de control del tabaco. Sin embargo, todavía queda por avanzar para acercarnos a lo sugerido por la OMS. De mantenerse el nivel de consumo entre los adolescentes de la región actualmente, observaremos en las décadas futuras un incremento en el número de muertes prematuras y evitables causadas por el tabaco.

Projections based on the most recent report on the Global Burden of Disease show that the observed increase in smoking prevalence in middle and low income countries will contribute to the increase of the number of deaths due to cardiovascular diseases, chronic obstructive pulmonary diseases, and some cancers. The World Health Organization (WHO) Framework Convention on Tobacco Control recommends a group of actions to curb the tobacco epidemic. This is a review paper based on the most recent MPOWER report and also included in this review are some of the most recent tobacco control measures implemented during 2009 and 2010. We conclude that most Latin American countries have achieved significant progress in tobacco control in recent years. However, when comparing the current situation against the WHO recommendations we realized that for most countries there is still work to be done. If current smoking prevalence among teenagers remains unchanged, there will be a significant increase in the number of premature deaths attributable to tobacco consumption in future decades.