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1.
Gen Dent ; 71(3): 47-51, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37083613

RESUMO

The objective of this case report is to describe the treatment of a dentofacial and temporomandibular joint (TMJ) deformity by means of reconstruction with a customized TMJ prosthesis and orthognathic surgery. The article discusses the therapeutic approach and the importance of functional and esthetic rehabilitation of the patient. A 22-year-old man displayed sequelae of osteomyelitis diagnosed at 6 years of age, including facial asymmetry, laterognathism, unsatisfactory occlusion, and mandibular retrognathism. Computed tomography revealed a deformity of the left mandibular condyle, ramus, and fossa. The patient underwent 1-stage surgery that involved bimaxillary orthognathic surgery and mentoplasty in conjunction with reconstruction of the left TMJ with a customized prosthesis. Postoperatively, substantial improvement was observed in the patient's facial pattern and masticatory function, and the beneficial changes have been maintained through 2 years of follow-up. The positive outcome in this patient suggests that TMJ reconstruction using a customized prosthesis in combination with computer-guided orthognathic surgery can be a satisfactory approach to correct a mandibular defect. The advantages of 1-stage surgery for the surgeon include shorter treatment time and more predictable results, while the benefits for the patient are good esthetic and functional results and improved quality of life.


Assuntos
Prótese Articular , Cirurgia Ortognática , Transtornos da Articulação Temporomandibular , Masculino , Humanos , Adulto Jovem , Adulto , Qualidade de Vida , Transtornos da Articulação Temporomandibular/cirurgia , Articulação Temporomandibular/diagnóstico por imagem , Articulação Temporomandibular/cirurgia
2.
Gen Dent ; 71(6): 73-77, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37889248

RESUMO

Dentoalveolar trauma is an important etiologic factor for tooth loss. A multidisciplinary approach to treatment is necessary because the functional, esthetic, and psychosocial problems that result from dentoalveolar trauma can significantly influence the patient's quality of life. The objective of this article is to describe the multidisciplinary treatment of a 39-year-old man who experienced dentoalveolar trauma in a bicycle accident. Clinical and tomographic examinations revealed the avulsion of the maxillary left central incisor as well as coronal fractures of the other incisors and the maxillary right canine. The maxillary right central incisor had a subgingival fracture, and the treatment included endodontic treatment followed by orthodontic extrusion using a temporary intraradicular retention pin and an orthodontic elastic band attached to a provisional prosthesis for anchorage. A dental implant and a connective tissue graft were placed at the site of the avulsed tooth. Subsequently, 5 zirconia crowns were fabricated using a digital workflow. In some cases of dentoalveolar trauma, orthodontic extrusion accomplished with the aid of the provisional prosthesis can be a conservative, fast, and economical option to preserve periodontal tissues and restore the biologic width. In the present case, the combination of orthodontic extrusion, implant placement, and a digital workflow ensured the precision, comfort, and esthetics of the final restorations, improving the quality of life of the patient.


Assuntos
Implantes Dentários , Avulsão Dentária , Perda de Dente , Masculino , Humanos , Adulto , Qualidade de Vida , Coroas , Maxila , Estética Dentária
3.
Gen Dent ; 71(4): 44-47, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37358582

RESUMO

This article reports the treatment of 2 cases of mandibular third molar displacement into deep fascial spaces during attempted extraction, 1 of which resulted in acute infection. In addition to treatment approaches, the article reviews the risk factors for tooth displacement and techniques that may be used for its prevention. In both of the reported cases, after tooth extraction procedures resulted in the displacement of a third molar, the correct location of the tooth was ascertained by 3-dimensional imaging. The displaced tooth was removed via intraoral access while the patient wasunder general anesthesia. Both patients healed without postsurgical complications, confirming the success of the treatment.


Assuntos
Anormalidades Dentárias , Dente Impactado , Humanos , Dente Serotino/diagnóstico por imagem , Dente Serotino/cirurgia , Dente Molar , Extração Dentária/efeitos adversos , Extração Dentária/métodos , Anormalidades Dentárias/etiologia , Dente Impactado/diagnóstico por imagem , Dente Impactado/cirurgia , Dente Impactado/etiologia , Mandíbula/diagnóstico por imagem , Mandíbula/cirurgia
4.
Gen Dent ; 70(1): 61-64, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34978993

RESUMO

This article presents a case of an epidermoid cyst that mimicked a thyroglossal duct cyst in a pediatric patient. An 8-year-old boy was referred for evaluation of a volumetric increase in the median cervical region with an evolution of about 4 years. The skin in the submental region was healthy and normal colored. Palpation revealed a mobile, well-circumscribed nodular lesion of soft consistency. Computed tomography of the neck showed an expansive hypodense formation extending from the base of the tongue to the upper portion of the hyoid bone, suggesting a thyroglossal duct cyst. Considering the diagnostic hypothesis, cystic enucleation via the Sistrunk procedure was planned. However, no ductal structure was identified during the surgical procedure, and the lesion was only near, but not attached to, the hyoid bone. Simple excision of the lesion was therefore performed. At the most recent follow-up examination, about 3 months postoperatively, the patient demonstrated satisfactory clinical progress. The epidermoid cyst close to the hyoid bone presented diagnostic difficulty due to its similarity to a thyroglossal duct cyst. Computed tomography provides limited information for diagnosing this type of lesion, and ultrasonography is the preferred test. In view of the uncertain diagnosis in this case, the extent of the excision was determined during the surgery, and simple excision was a satisfactory treatment associated with a good prognosis.


Assuntos
Cisto Epidérmico , Cisto Tireoglosso , Criança , Cisto Epidérmico/diagnóstico por imagem , Cisto Epidérmico/cirurgia , Humanos , Osso Hioide/diagnóstico por imagem , Osso Hioide/cirurgia , Masculino , Pescoço , Cisto Tireoglosso/diagnóstico por imagem , Cisto Tireoglosso/cirurgia , Língua
5.
Support Care Cancer ; 29(11): 6981-6993, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33988743

RESUMO

PURPOSE: This systematic review aimed to identify effective medicinal plants for the treatment of mucositis induced by oncotherapy. METHODS: The clinical question was the following: "Which medicinal plants are effective in the treatment of oral mucositis induced by cancer treatment?" (PubMed, Medline, Web of Science, Scopus, Lilacs, and SciELO). The keywords were the following: phytotherapy OR "herbal drug" OR "plant extract" OR plant OR "medicinal plant" OR pharmacognosy OR ethnobotany OR ethnomedicine OR ethnopharmacology OR "flower essences" OR "natural product" AND mucositis OR mucositides OR stomatitis OR stomatitides OR "oral ulcer" AND chemotherapy OR radiotherapy OR immunotherapy OR cancer OR neoplasm OR neoplasm OR tumor OR tumor. The inclusion criteria for the selection of articles were the type of study design (clinical trials) and the studied population (cancer patients presenting lesions of oral mucositis having undergone treatment with medicinal plants). RESULTS: After evaluation of the works, 24 of 893 articles were selected. Matricaria chamomilla (chamomilla) presented promising results, such as a reduction in severity and lesion incidence with improved pain symptomatology. The plant extracts Isatis indigótica, Olea europaea, Calendula officinalis, A. digitatae, and M. sylvestris improved the lesions. Mucotrol™ and QRLYD herbal products improved the degree of severity of the lesions, while SAMITAL® and MUCOSYTE allowed for greater pain control. CONCLUSION: The complementary treatment of oral mucositis in cancer patients, with analgesic and anti-inflammatory actions with lower side effects, is an alternative for healthcare professionals.


Assuntos
Mucosite , Plantas Medicinais , Estomatite , Humanos , Medicina Tradicional , Mucosite/tratamento farmacológico , Fitoterapia , Estomatite/induzido quimicamente , Estomatite/tratamento farmacológico
6.
Br J Clin Pharmacol ; 86(11): 2325-2327, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32307721

RESUMO

A 66-year-old woman diagnosed clinical manifestation of extensive hard palate hyperpigmentation is presented. Due to historic of rheumatoid arthritis and use of chloroquine phosphate for 3 years, exogenous hyperpigmentation associated with the drug was included among the possible diagnoses. Incisional biopsy was performed and the histopathological exam confirmed exogenous hyperpigmentation compatible with chloroquine use. The patient was referred to the rheumatologist and the ophthalmologist for evaluation of the continuity of the chloroquine use. After one year of follow-up, no changes were seen in the hyperpigmentation nor other clinical changes. Hyperpigmentation of the hard palate by the use of chloroquine is one of the adverse effects of the chronic use of this drug and does not require specific treatment. The adequate anamnesis and the knowledge about the adverse effects of the drug allowed an adequate therapeutic approach in the case.


Assuntos
Artrite Reumatoide , Hiperpigmentação , Idoso , Artrite Reumatoide/tratamento farmacológico , Biópsia , Cloroquina/efeitos adversos , Feminino , Humanos , Hiperpigmentação/induzido quimicamente , Hiperpigmentação/diagnóstico , Palato Duro
7.
J Oral Implantol ; 45(4): 297-299, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31207195

RESUMO

This case report describes the rehabilitation of a patient who received dental implants in traumatic bone cyst areas (TBC). A 24-year-old male patient sought dental treatment for the bilateral absence of the mandibular second premolars. Radiographic examination revealed bilateral large radiolucent images in the mandible body. Surgical exploration confirmed the diagnosis of TBC. Rehabilitation with dental implants was performed using different approaches on each side. One cystic cavity was filled with blood clot and allogenic bone graft; the other was filled only with blood clot. After 5 years, the implants are osseointegrated and functioning. The filling of the traumatic bone cyst cavity with local blood clot in contact with the implant presented clinical and radiographic success similar to that obtained with filling with bone graft in the same patient. Thus, in this patient, the blood clot-only approach can be considered as a viable, safe-low cost alternative to blood clot and grafting material.


Assuntos
Cistos Ósseos , Transplante Ósseo , Implantes Dentários , Cistos Ósseos/cirurgia , Implantação Dentária Endóssea , Prótese Dentária Fixada por Implante , Seguimentos , Humanos , Masculino , Mandíbula , Adulto Jovem
10.
ScientificWorldJournal ; 2014: 983728, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25436238

RESUMO

The aim of this study was to determine, by Atomic Absorption Spectrometry (AAS), the concentration levels of 11 metals in Type V gray and structural white PC, ProRoot MTA, and MTA Bio. Samples, containing one gram of each tested cement, were prepared and transferred to a 100 mL Teflon tube with a mixture of 7.0 mL of nitric acid and 21 mL of hydrochloric acid. After the reaction, the mixture was filtered and then volumed to 50 mL of distilled water. For each metal, specific patterns were determined from universal standards. Arsenic quantification was performed by hydride generator. The analysis was performed five times and the data were statistically analyzed at 5% level of significance. Only the cadmium presented concentration levels of values lower than the quantification limit of the device. The AAS analysis showed increased levels of calcium, nickel, and zinc in structural white PC. Type V PC presented the greatest concentration levels of arsenic, chromium, copper, iron, lead, and manganese (P < 0.05). Bismuth was found in all cements, and the lowest concentration levels were observed in Portland cements, while the highest were observed in ProRoot MTA. Both PC and MTA-based cements showed evidence of metals inclusion.


Assuntos
Cimentos Dentários/análise , Cimentos Dentários/normas , Metais Pesados/análise , Cimentos Dentários/química , Metais Pesados/química , Espectrofotometria Atômica/métodos
11.
Gen Dent ; 62(2): e20-2, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24598505

RESUMO

Taurodontism is a developmental anomaly that manifests as an alteration in a patient's internal morphology and is characterized by the lack of constriction at the level of the cementoenamel junction, which results in an apical extension of the pulp chamber that extends into the root area of a multiradicular tooth. This report presents a case of an otherwise healthy patient with 12 hypertaurodontic teeth, which were detected by using cone beam computed tomography (CBCT). It is essential to emphasize the importance of routine imaging examinations for diagnosing developmental dental anomalies such as taurodontism, as this condition is generally not found by routine oral examination, and is not necessarily restricted to syndromic patients. CBCT images contribute to the diagnosis of and treatment plan for taurodontism.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Cavidade Pulpar/anormalidades , Anormalidades Dentárias/diagnóstico por imagem , Adolescente , Cavidade Pulpar/diagnóstico por imagem , Feminino , Humanos , Radiografia Panorâmica , Anormalidades Dentárias/classificação
12.
J Contemp Dent Pract ; 15(2): 209-13, 2014 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-25095845

RESUMO

The objective of this study was to estimate the prevalence of impacted teeth in a subpopulation of Brazilian patients based on the retrospective analysis of panoramic radiographs obtained at an oral radiology clinic. Out of 1,977 panoramic radiographs, 1,352 fulfilled inclusion criteria, and 22,984 teeth were assessed. Data were statistically analyzed using Kolmogorov-Smirnov's and Levene's tests; significance was set at 5%. The number of impacted teeth was assessed using analysis of variance and Tukey's post-hoc test. Our results showed significant differences for tooth type and patient age when analyzed separately (p < 0.05); gender did not show significant results (p > 0.05). Correlations between age and gender showed significant differences (p < 0.05), as did the correlations between age, gender and tooth type (p < 0.05). Mandibular molars were the teeth most frequently affected (p < 0.05), followed by maxillary molars (p < 0.05). Other tooth types did not present significant differences among themselves (p > 0.05). Patients aged 22 years or younger were the most frequent ones (p < 0.05). No significant differences were observed between age groups 37 and 51 years and 52+ (p > 0.05). According to the methodology here employed, gender did not affect tooth impaction, whereas age (22-36 years) and tooth type (mandibular third molars) strongly influenced results.


Assuntos
Dente Impactado/epidemiologia , Adolescente , Adulto , Fatores Etários , Brasil/epidemiologia , Dente Canino/diagnóstico por imagem , Feminino , Humanos , Masculino , Mandíbula/diagnóstico por imagem , Maxila/diagnóstico por imagem , Pessoa de Meia-Idade , Dente Molar/diagnóstico por imagem , Dente Serotino/diagnóstico por imagem , Prevalência , Radiografia Panorâmica/estatística & dados numéricos , Estudos Retrospectivos , Fatores Sexuais , Dente Impactado/diagnóstico por imagem , Dente Supranumerário/diagnóstico por imagem , Dente Supranumerário/epidemiologia , Adulto Jovem
13.
J Clin Exp Dent ; 16(2): e236-e239, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38496816

RESUMO

This article presents the rare case of a patient with gemination and fusion involving conical supernumerary teeth and the second mandibular molar, along with its treatment. The 13-year-old girl, without any associated syndromes and currently undergoing orthodontic treatment, was referred for evaluation due to the presence of a supernumerary tooth. Following a clinical examination and analysis of a panoramic radiograph, a cone beam computed tomography was requested for a more detailed assessment of the supernumerary tooth and its relationship with adjacent structures. The sagittal sections revealed the presence of two conical paramolar supernumerary teeth, which were geminated and fused to the mesial root of tooth 47. The suggested treatment was the surgical removal of the supernumerary teeth, which was successfully performed without complications and with good healing. After one-year post-procedure, the formation of periodontal ligament was verified at the site where the supernumerary teeth were extracted. The simultaneous occurrence of gemination of two supernumerary teeth and their fusion to a mandibular molar is extremely rare, and their surgical removal provided the patient with better plaque control in the region and contributed to the progress of orthodontic treatment. Key words:Gemination and fusion of supernumerary teeth and second mandibular molar.

14.
Braz Dent J ; 33(1): 96-104, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35262558

RESUMO

Bacteria are related do different oral diseases, such as dental caries and periodontal disease. Therefore, the control or/and eradication of microorganisms and their by-products is primordial for the success of their treatment. An alternative for decrease bacterial load is the use of plant extracts used in popular medicine. The cytotoxicity and antimicrobial action of extracts of Cariniana rubra Gardiner ex Miers, Senna martiniana, Anadenanthera colubrina (Vell.) Brenan and Spiranthera odoratissima St. Hil. against strains of Streptococcus mutans, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Aggregatibacter actinomyces- tencomitans and Candida albicans were investigated. Cytotoxicity was assessed at concentrations of 1, 10, 40, 80, 100 and 1000 µg/mL by means of the MTT test and compared to a control group with untreated cells. Those with acceptable cytotoxicity had the antimicrobial action measured by the XTT test. As a positive control, sodium hypochlorite was used. Cariniana rubra Gardiner ex Miers had the highest citototoxicity results while Spiranthera odoratissima St. Hil. had the best results, but all extracts showed acceptable cytotoxicity at different concentrations. The plant extracts showed higher activity against A. actinomycetencomitans: Anadenanthera columbrina (Vell.) Brenan (80.52%) at 40 µg/mL, Spiranthera odoratissima St. Hil (78.48%) in 1 µg/mL, Senna martiniana (73.28%) in the concentration of 40 µg/mL and Cariniana rubra Gardiner ex Miers (70.50%) in 10 µg/mL. All extracts analyzed showed acceptable cytotoxicity at different concentrations and were promising for inhibition of the pathogenic microorganisms studied.


Assuntos
Anti-Infecciosos , Cárie Dentária , Antibacterianos/farmacologia , Anti-Infecciosos/farmacologia , Cárie Dentária/microbiologia , Humanos , Testes de Sensibilidade Microbiana , Extratos Vegetais/farmacologia , Streptococcus mutans
15.
J Dent (Shiraz) ; 21(1): 31-41, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32158782

RESUMO

STATEMENT OF THE PROBLEM: Head and neck cancer treatment has provided better cure and survival rates but the patient's quality of life is still an issue. PURPOSE: To verify the correlation between the three most used instruments for evaluating the quality of life of head and neck cancer patients. MATERIALS AND METHOD: This cross-sectional study evaluated patients treated for head and neck cancer at the Mato Grosso Cancer Hospital, Cuiabá, MT, Brazil. The variables age, gender, cohabitation status, education, religion, smoking, ethnicity, tumor location and histological type and treatment modality were collected. The patients quality of life was assessed by the Functional Assessment of Cancer Therapy Quality of Life Measurement System (FACT-H&N), University of Washington Quality of Life Questionnaire (UW-QOL), and EORTC QLQ-C30/EORTC QLQ-H&N35 of the European Organization for Research and Treatment of Cancer. RESULTS: The study population consisted of 33 individuals with a mean age of 63.42±11.25 years; 69.70% were males; 54.55% had no partner; 45.45% had only elementary education; 87.9% followed a religion; 84.38% were smokers and 87.50% alcoholics. Squamous cell carcinoma responded for 78.79% of the cases and palate/oropharynx and mouth floor (21.21% each) were the most affected sites. All patients underwent radiotherapy, 90.91% chemotherapy and 63.64% surgery. On the analysis of quality of life, shoulder (UW-QOL), social performance (EORTC QLQ-C30/QLQ-H&N35) and overall well-being (FACT-H&N) had the highest scores while saliva (UW-QOL), nausea and vomiting (EORTC QLQ-C30/QLQ-H&N35) and emotional well-being (FACT-H&N) had the lowest scores. A positive correlation was found between the questionnaires for the patient's overall quality of life and the domains Pain, Appearan-ce, Activity, Deglutition, Chewing, Speech, Taste, Saliva, Mood and Anxiety. CONCLUSION: Given the correlation between the questionnaires, the selection of the instrument for future research involving head and neck cancer patients' quality of life should consider the specific aspects to be evaluated.

16.
J Dent (Shiraz) ; 21(2): 119-126, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32582827

RESUMO

STATEMENT OF THE PROBLEM: Non-syndromic cleft lip and palate are the most frequent craniofacial abnormalities in humans. The genetic, environmental and behavioral factors involved in this malformation must be clarified in different parts of the globe in the view of implementing preventive measures. PURPOSE: To analyze the influence of parental exposure to risk factors on the occurrence of oral clefts. MATERIALS AND METHOD: A case-control study was conducted with 150 mothers of oral cleft children paired by the children's gender to 300 mothers of children without congenital anomalies from Mato Grosso, Brazil, for the study of the variables: gender and race/color of the children; parental educational level; age; number of pregnancies; prenatal care; obesity; stress; diabetes; hypertension; use of medications, alcohol and illicit drugs; smoking and exposure to ionizing radiation during the first trimester of pregnancy. The results were analyzed in relation to the chances possibility of each variable for the occurrence of oral cleft through the bivariate and multivariate analysis by applying the model of logistic regression. RESULTS: Passive smoking, obesity, exposure to ionizing radiation and use of antibiotics were associated with the presence of clefts. The use of folic acid and analgesics were identified as preventive factors. The father's low educational level was found as a risk factor, while the black race/color was a preventive factor; nevertheless these variables were not associated in the multivariate analysis. CONCLUSION: The results reinforce the need to follow up the pregnant women, especially in the first trimester of pregnancy, in order to control the identified risk factors. Considering the factors associated with occurrence of oral clefts and those associated with its prevention, it is possible to apply specific health promotion measures during pregnancy, which can result in the reduction of oral clefts' occurrence.

17.
Braz. dent. sci ; 27(1): 1-18, 2024. ilus, tab
Artigo em Inglês | LILACS, BBO - odontologia (Brasil) | ID: biblio-1554280

RESUMO

Objective: To identify and analyze plant extracts used in Brazil for the treatment of oral ulcers and oral mucositis. Material and Methods: A systematic review was registered in PROSPERO (CRD 42018102184) and performed following the PRISMA protocol. The databases searched were PubMed, Web of Science, Scopus, Lilacs, Scielo, the Brazilian Dentistry Library. Manual searches were also performed. Results: Initially, 440 studies were found, of which 392 were excluded after reading the titles and abstracts. A total of 29 articles were read in full and 11 studies were excluded, resulting in 18 articles included in the systematic review. Nine plant species were identified in five clinical trials and 13 in vivo studies, with Chamomila recutita being the most used (33.3% of the studies). Chamomila recutita showed more promising results for analgesic, anti-inflammatory, and healing properties. Calotropis procera latex significantly decreased (p<0.05) inflammatory mediators, such as TNF-α and IL-1ß in oral mucositis induced in rats. Eupatorium laevigatum showed anti-inflammatory activity and analgesic action on oral ulcers. Carapa guianensis Aubl. reduced the severity and painful symptoms of oral mucositis and exhibited better results compared to the use of low power laser. Curcuma longa L accelerated re-epithelialization and resolution of inflammatory processes. Spondias mombin reduced oxidative stress and inflammation caused by oral mucositis and helped on healing it. Extracts of Aloe barbadensis Miller or Aloe vera showed anti-inflammatory action but did not help in the healing process of oral ulcers. Copaifera reticulata Ducke oil did not induce improvement in the healing process, nor did it show an anti-inflammatory effect. Malva sylvestrisdid not show an anti-inflammatory action on oral lesions in humans or rats. The assessment of methodological heterogeneity showed the impossibility of performing a meta-analysis. Risk of bias varied from low to high. Conclusion: The plant species most used and with the best results for the treatment of oral ulcerations and oral mucositis was Chamomilla recutita. Spondias mombin L., Curcuma longa L., Carapa guianensis Aubl and Calotropis procera showed good results in the treatment of oral mucositis, while Eupatorium laevigatum was efficient in the treatment of ulcers of traumatic origin. Malva sylvestris, Copaifera reticulata Ducke, and Aloe barbadensis Miller did not exhibit significant results (AU)


Objetivo: Identificar e analisar extratos vegetais utilizados no Brasil para o tratamento de úlceras orais e mucosite oral. Material e Métodos: Uma revisão sistemática foi registrada no PROSPERO (CRD 42018102184) e realizada seguindo o protocolo PRISMA. As bases de dados pesquisadas foram PubMed, Web of Science, Scopus, Lilacs, Scielo, Biblioteca Brasileira de Odontologia. Buscas manuais também foram realizadas. Resultados: Inicialmente, foram encontrados 440 estudos, dos quais 392 foram excluídos após a leitura dos títulos e resumos. Um total de 29 artigos oram lidos na íntegra e 11 estudos foram excluídos, resultando em 18 artigos incluídos na revisão sistemática. Nove espécies vegetais foram identificadas em cinco ensaios clínicos e 13 estudos in vivo, sendo a Chamomila recutita a mais utilizada (33,3% dos estudos). A Chamomila recutita apresentou resultados mais promissores quanto às propriedades analgésicas, anti-inflamatórias e cicatrizantes. O látex de Calotropis procera diminuiu significativamente (p<0,05) os mediadores inflamatórios, como TNF-α e IL-1ß, na mucosite oral induzida em ratos. Eupatorium laevigatumapresentou atividade anti-inflamatória e ação analgésica em úlceras orais. Carapa guianensis Aubl. reduziu a gravidade e os sintomas dolorosos da mucosite oral e apresentou melhores resultados em comparação com o uso do laser de baixa potência. Curcuma longa L. acelerou a reepitelização e resolução de processos inflamatórios. Spondias mombinreduziu o estresse oxidativo e a inflamação causadas pela mucosite oral e ajudou na sua cicatrização. Extratos de Aloe barbadensis Miller ou Aloe vera apresentaram ação anti-inflamatória, mas não auxiliaram no processo de cicatrização de úlceras orais. O óleo de Copaifera reticulata Ducke não induziu melhora no processo cicatricial, nem apresentou efeito anti-inflamatório. Malva sylvestris não apresentou ação anti-inflamatória em lesões orais em humanos ou ratos. A avaliação da heterogeneidade metodológica mostrou a impossibilidade de realizar uma meta-análise. O risco de viés variou de baixo a alto. Conclusão: A espécie vegetal mais utilizada e com melhores resultados para o tratamento de ulcerações orais e mucosite oral foi a Chamomilla recutita. Spondias mombin L., Curcuma longa L., Carapa guianensis Aubl e Calotropis procera apresentaram bons resultados no tratamento da mucosite oral, enquanto Eupatorium laevigatum foi eficiente no tratamento de úlceras de origem traumática. Malva sylvestris, Copaifera reticulata Duckee Aloe barbadensis Miller não apresentaram resultados significativos(AU)


Assuntos
Plantas Medicinais , Estomatite , Extratos Vegetais , Úlceras Orais , Mucosite , Fitoterapia
18.
Case Rep Pathol ; 2018: 8428395, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30186652

RESUMO

BACKGROUND: Field cancerization is a phenomenon in which prolonged exposure to carcinogens induces changes throughout the epithelium leaving the field ready for the appearance of premalignant or malignant lesions. These alterations can promote the development of multiple carcinomas and explain the appearance of recurrences and second primary tumors. The objective of this study was to report the case of a patient who developed six oral cavity tumors in five years of treatment and, also, demonstrate the immunohistochemical changes for p53 and Ki-67, routinely used to assess dysplasic regions. CASE REPORT: When altered, p53 and Ki-67 suggest the presence of field cancers, an area with genetically altered cells, presenting a high risk of developing premalignant and malignant lesions. This phenomenon explains the recurrence of malignant neoplasms after tumor resections. CONCLUSION: In addition, early identification of potentially malignant lesions in cases of second primary tumors is essential for effective treatment and patient survival, which usually have an unwelcoming prognosis.

19.
Braz J Otorhinolaryngol ; 73(4): 562-8, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17923929

RESUMO

UNLABELLED: Increasing the intensity of radiation therapy and chemotherapy in the management of cancer has increased the incidence of adverse effects, especially oral mucositis. AIM AND METHODS: a bibliographical review was conducted on the definition of oral mucositis, its clinical findings, the incidence, its etiology, the pathophysiology, associated morbidity, prevention and treatment. RESULTS: current studies define oral mucositis as a very frequent and painful inflammation with ulcers on the oral mucosa that are covered by a pseudo membrane. The incidence and severity of lesions are influenced by patient and treatment variables. Oral mucositis is a result of two major mechanisms: direct toxicity on the mucosa and myelosuppression due to the treatment. Its pathophysiology is composed of four interdependent phases: an initial inflammatory/vascular phase; an epithelial phase; an ulcerative/bacteriological phase; and a healing phase. It is considered a potential source of life-threatening infection and often is a dose-limiting factor in anticancer therapy. Some interventions have been shown to be potentially effective to prevent and treat oral mucositis. Further intensive research through well-structured clinical trials to obtain the best scientific evidence over the standard therapy of oral mucositis is necessary to attain ideal parameters for radiotherapy and chemotherapy.


Assuntos
Antineoplásicos/efeitos adversos , Radioterapia/efeitos adversos , Estomatite/etiologia , Humanos , Mucosa Bucal/efeitos dos fármacos , Mucosa Bucal/efeitos da radiação , Neoplasias/tratamento farmacológico , Neoplasias/radioterapia , Estomatite/fisiopatologia , Estomatite/terapia
20.
Rev. odontol. UNESP (Online) ; 51: e20220033, 2022. tab
Artigo em Português | LILACS, BBO - odontologia (Brasil) | ID: biblio-1409935

RESUMO

Resumo Introdução a pandemia da Covid-19 e medidas de controle da sua expansão impactaram diferentes segmentos da economia, dentre eles os profissionais da Odontologia. Objetivo este trabalho analisou o impacto financeiro gerado pela pandemia da Covid-19 aos técnicos de prótese dentária (TPDs) no Brasil. Material e método por meio de um estudo transversal descritivo, aplicou-se aos TPDs do Brasil um questionário relacionado ao perfil sociodemográfico e profissional, impacto financeiro e medidas adotadas para minimizar seus efeitos. O questionário foi aplicado de forma on-line em redes sociais entre 27 de janeiro e 15 de fevereiro de 2021. Resultado demonstrou-se que 59,8% dos participantes eram do sexo masculino; 47,5% até 30 anos de idade e 57,3% com menos de 10 anos de prática. As medidas para contenção da propagação do coronavírus impactaram financeiramente 89,6% dos participantes; 72,0% interromperam totalmente seus trabalhos; 97,7% tiveram redução no faturamento; 98,2% tiveram mudança na rotina de trabalho; 94,8% tiveram aumento das despesas do laboratório no período; houve queda do faturamento para 41,2% entre 0% e 25,0% e para 36,3% entre 25,0% e 50,0%; 66,6% continuaram trabalhando durante a pandemia devido à sua situação financeira. Não pensaram em fechar seu laboratório de forma definitiva 71,8% dos participantes; 92,2% seguiram rotineiramente os cuidados de higienização e 21,6% fizeram uso das reservas financeiras. Conclusão os TPDs tiveram impacto financeiro durante o período da pandemia da Covid-19 causado principalmente pela diminuição da carga horária de trabalho, redução do faturamento e aumento do custo operacional devido à mudança na rotina de biossegurança.


Abstract Introduction the COVID-19 pandemic and measures to control its expansion impacted different segments of the economy, including dentistry professionals. Objective this study analyzed the financial impact of the COVID-19 pandemic on dental technicians in Brazil. Material and method this is a descriptive cross-sectional study with the application of a questionnaire of sociodemographic and professional profile, financial impact, and effect containment measures to dental technicians in Brazil. The questionnaire was applied online on social networks between January 27 and February 15, 2021. Result 59.8% of the participants were male, with 47.5% aged up to 30 years, and 57.3% with less than 10 years of practice. The measures to contain the spread of the coronavirus had a financial impact on 89.6% of the participants: 72.0% had their work completely interrupted, 97.7% had their billing reduced, 98.2% changed their work routine, and 94.8% had higher laboratory expenses in the period. Revenue decreased between 0% and 25.0% for 41.2% and between 25.0% and 50.0% for 36.3%. In addition, 66.6% continued working during the pandemic due to their financial situation. 71.8% of the participants did not consider closing their laboratory permanently, whereas 92.2% followed hygiene protocols routinely and 21.6% made use of their financial reserves. Conclusion dental technicians were financially impacted by the COVID-19 pandemic, mainly caused by fewer working hours, revenue reduction, and higher operating costs due to the change in the biosafety routine.


Assuntos
Inquéritos e Questionários , Técnicos em Prótese Dentária , Remuneração , COVID-19
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