Transferability Based on Drug Structure Similarity in the Automatic Classification of Noncompliant Drug Use on Social Media: Natural Language Processing Approach.

BACKGROUND: Medication noncompliance is a critical issue because of the increased number of drugs sold on the web. Web-based drug distribution is difficult to control, causing problems such as drug noncompliance and abuse. The existing medication compliance surveys lack completeness because it is impossible to cover patients who do not go to the hospital or provide accurate information to their doctors, so a social media-based approach is being explored to collect information about drug use. Social media data, which includes information on drug usage by users, can be used to detect drug abuse and medication compliance in patients. OBJECTIVE: This study aimed to assess how the structural similarity of drugs affects the efficiency of machine learning models for text classification of drug noncompliance. METHODS: This study analyzed 22,022 tweets about 20 different drugs. The tweets were labeled as either noncompliant use or mention, noncompliant sales, general use, or general mention. The study compares 2 methods for training machine learning models for text classification: single-sub-corpus transfer learning, in which a model is trained on tweets about a single drug and then tested on tweets about other drugs, and multi-sub-corpus incremental learning, in which models are trained on tweets about drugs in order of their structural similarity. The performance of a machine learning model trained on a single subcorpus (a data set of tweets about a specific category of drugs) was compared to the performance of a model trained on multiple subcorpora (data sets of tweets about multiple categories of drugs). RESULTS: The results showed that the performance of the model trained on a single subcorpus varied depending on the specific drug used for training. The Tanimoto similarity (a measure of the structural similarity between compounds) was weakly correlated with the classification results. The model trained by transfer learning a corpus of drugs with close structural similarity performed better than the model trained by randomly adding a subcorpus when the number of subcorpora was small. CONCLUSIONS: The results suggest that structural similarity improves the classification performance of messages about unknown drugs if the drugs in the training corpus are few. On the other hand, this indicates that there is little need to consider the influence of the Tanimoto structural similarity if a sufficient variety of drugs are ensured.

Disruptions in the Cystic Fibrosis Community's Experiences and Concerns During the COVID-19 Pandemic: Topic Modeling and Time Series Analysis of Reddit Comments.

BACKGROUND: The COVID-19 pandemic disrupted the needs and concerns of the cystic fibrosis community. Patients with cystic fibrosis were particularly vulnerable during the pandemic due to overlapping symptoms in addition to the challenges patients with rare diseases face, such as the need for constant medical aid and limited information regarding their disease or treatments. Even before the pandemic, patients vocalized these concerns on social media platforms like Reddit and formed communities and networks to share insight and information. This data can be used as a quick and efficient source of information about the experiences and concerns of patients with cystic fibrosis in contrast to traditional survey- or clinical-based methods. OBJECTIVE: This study applies topic modeling and time series analysis to identify the disruption caused by the COVID-19 pandemic and its impact on the cystic fibrosis community's experiences and concerns. This study illustrates the utility of social media data in gaining insight into the experiences and concerns of patients with rare diseases. METHODS: We collected comments from the subreddit r/CysticFibrosis to represent the experiences and concerns of the cystic fibrosis community. The comments were preprocessed before being used to train the BERTopic model to assign each comment to a topic. The number of comments and active users for each data set was aggregated monthly per topic and then fitted with an autoregressive integrated moving average (ARIMA) model to study the trends in activity. To verify the disruption in trends during the COVID-19 pandemic, we assigned a dummy variable in the model where a value of "1" was assigned to months in 2020 and "0" otherwise and tested for its statistical significance. RESULTS: A total of 120,738 comments from 5827 users were collected from March 24, 2011, until August 31, 2022. We found 22 topics representing the cystic fibrosis community's experiences and concerns. Our time series analysis showed that for 9 topics, the COVID-19 pandemic was a statistically significant event that disrupted the trends in user activity. Of the 9 topics, only 1 showed significantly increased activity during this period, while the other 8 showed decreased activity. This mixture of increased and decreased activity for these topics indicates a shift in attention or focus on discussion topics during this period. CONCLUSIONS: There was a disruption in the experiences and concerns the cystic fibrosis community faced during the COVID-19 pandemic. By studying social media data, we were able to quickly and efficiently study the impact on the lived experiences and daily struggles of patients with cystic fibrosis. This study shows how social media data can be used as an alternative source of information to gain insight into the needs of patients with rare diseases and how external factors disrupt them.

Diagnosing psychiatric disorders from history of present illness using a large-scale linguistic model.

AIM: Recent advances in natural language processing models are expected to provide diagnostic assistance in psychiatry from the history of present illness (HPI). However, existing studies have been limited, with the target diseases including only major diseases, small sample sizes, or no comparison with diagnoses made by psychiatrists to ensure accuracy. Therefore, we formulated an accurate diagnostic model that covers all psychiatric disorders. METHODS: HPIs and diagnoses were extracted from discharge summaries of 2,642 cases at the Nara Medical University Hospital, Japan, from 21 May 2007, to 31 May 31 2021. The diagnoses were classified into 11 classes according to the code from ICD-10 Chapter V. Using UTH-BERT pre-trained on the electronic medical records of the University of Tokyo Hospital, Japan, we predicted the main diagnoses at discharge based on HPIs and compared the concordance rate with the results of psychiatrists. The psychiatrists were divided into two groups: semi-Designated with 3-4 years of experience and Residents with only 2 months of experience. RESULTS: The model's match rate was 74.3%, compared to 71.5% for the semi-Designated psychiatrists and 69.4% for the Residents. If the cases were limited to those correctly answered by the semi-Designated group, the model and the Residents performed at 84.9% and 83.3%, respectively. CONCLUSION: We demonstrated that the model matched the diagnosis predicted from the HPI with a high probability to the principal diagnosis at discharge. Hence, the model can provide diagnostic suggestions in actual clinical practice.

Automatic data extraction to support meta-analysis statistical analysis: a case study on breast cancer.

BACKGROUND: Meta-analyses aggregate results of different clinical studies to assess the effectiveness of a treatment. Despite their importance, meta-analyses are time-consuming and labor-intensive as they involve reading hundreds of research articles and extracting data. The number of research articles is increasing rapidly and most meta-analyses are outdated shortly after publication as new evidence has not been included. Automatic extraction of data from research articles can expedite the meta-analysis process and allow for automatic updates when new results become available. In this study, we propose a system for automatically extracting data from research abstracts and performing statistical analysis. MATERIALS AND METHODS: Our corpus consists of 1011 PubMed abstracts of breast cancer randomized controlled trials annotated with the core elements of clinical trials: Participants, Intervention, Control, and Outcomes (PICO). We proposed a BERT-based named entity recognition (NER) model to identify PICO information from research abstracts. After extracting the PICO information, we parse numeric outcomes to identify the number of patients having certain outcomes for statistical analysis. RESULTS: The NER model extracted PICO elements with relatively high accuracy, achieving F1-scores greater than 0.80 in most entities. We assessed the performance of the proposed system by reproducing the results of an existing meta-analysis. The data extraction step achieved high accuracy, however the statistical analysis step achieved low performance because abstracts sometimes lack all the required information. CONCLUSION: We proposed a system for automatically extracting data from research abstracts and performing statistical analysis. We evaluated the performance of the system by reproducing an existing meta-analysis and the system achieved a relatively good performance, though more substantiation is required.

Tweet Classification Toward Twitter-Based Disease Surveillance: New Data, Methods, and Evaluations.

BACKGROUND: The amount of medical and clinical-related information on the Web is increasing. Among the different types of information available, social media-based data obtained directly from people are particularly valuable and are attracting significant attention. To encourage medical natural language processing (NLP) research exploiting social media data, the 13th NII Testbeds and Community for Information access Research (NTCIR-13) Medical natural language processing for Web document (MedWeb) provides pseudo-Twitter messages in a cross-language and multi-label corpus, covering 3 languages (Japanese, English, and Chinese) and annotated with 8 symptom labels (such as cold, fever, and flu). Then, participants classify each tweet into 1 of the 2 categories: those containing a patient's symptom and those that do not. OBJECTIVE: This study aimed to present the results of groups participating in a Japanese subtask, English subtask, and Chinese subtask along with discussions, to clarify the issues that need to be resolved in the field of medical NLP. METHODS: In summary, 8 groups (19 systems) participated in the Japanese subtask, 4 groups (12 systems) participated in the English subtask, and 2 groups (6 systems) participated in the Chinese subtask. In total, 2 baseline systems were constructed for each subtask. The performance of the participant and baseline systems was assessed using the exact match accuracy, F-measure based on precision and recall, and Hamming loss. RESULTS: The best system achieved exactly 0.880 match accuracy, 0.920 F-measure, and 0.019 Hamming loss. The averages of match accuracy, F-measure, and Hamming loss for the Japanese subtask were 0.720, 0.820, and 0.051; those for the English subtask were 0.770, 0.850, and 0.037; and those for the Chinese subtask were 0.810, 0.880, and 0.032, respectively. CONCLUSIONS: This paper presented and discussed the performance of systems participating in the NTCIR-13 MedWeb task. As the MedWeb task settings can be formalized as the factualization of text, the achievement of this task could be directly applied to practical clinical applications.

Causal Relationships Among Pollen Counts, Tweet Numbers, and Patient Numbers for Seasonal Allergic Rhinitis Surveillance: Retrospective Analysis.

BACKGROUND: Health-related social media data are increasingly used in disease-surveillance studies, which have demonstrated moderately high correlations between the number of social media posts and the number of patients. However, there is a need to understand the causal relationship between the behavior of social media users and the actual number of patients in order to increase the credibility of disease surveillance based on social media data. OBJECTIVE: This study aimed to clarify the causal relationships among pollen count, the posting behavior of social media users, and the number of patients with seasonal allergic rhinitis in the real world. METHODS: This analysis was conducted using datasets of pollen counts, tweet numbers, and numbers of patients with seasonal allergic rhinitis from Kanagawa Prefecture, Japan. We examined daily pollen counts for Japanese cedar (the major cause of seasonal allergic rhinitis in Japan) and hinoki cypress (which commonly complicates seasonal allergic rhinitis) from February 1 to May 31, 2017. The daily numbers of tweets that included the keyword "kafunsho" (or seasonal allergic rhinitis) were calculated between January 1 and May 31, 2017. Daily numbers of patients with seasonal allergic rhinitis from January 1 to May 31, 2017, were obtained from three healthcare institutes that participated in the study. The Granger causality test was used to examine the causal relationships among pollen count, tweet numbers, and the number of patients with seasonal allergic rhinitis from February to May 2017. To determine if time-variant factors affect these causal relationships, we analyzed the main seasonal allergic rhinitis phase (February to April) when Japanese cedar trees actively produce and release pollen. RESULTS: Increases in pollen count were found to increase the number of tweets during the overall study period (P=.04), but not the main seasonal allergic rhinitis phase (P=.05). In contrast, increases in pollen count were found to increase patient numbers in both the study period (P=.04) and the main seasonal allergic rhinitis phase (P=.01). Increases in the number of tweets increased the patient numbers during the main seasonal allergic rhinitis phase (P=.02), but not the overall study period (P=.89). Patient numbers did not affect the number of tweets in both the overall study period (P=.24) and the main seasonal allergic rhinitis phase (P=.47). CONCLUSIONS: Understanding the causal relationships among pollen counts, tweet numbers, and numbers of patients with seasonal allergic rhinitis is an important step to increasing the credibility of surveillance systems that use social media data. Further in-depth studies are needed to identify the determinants of social media posts described in this exploratory analysis.

Extracting Spatio-Temporal Trends in Medical Research Prioritization Through Natural Language Processing of Case Report Abstracts.

Medical research prioritization is an important aspect of decision-making by researchers and relevant stakeholders. The ever-increasing availability of technology and data has opened doors to new discoveries and new questions. This makes it difficult for researchers and relevant stakeholders to make well-informed decisions about the research areas they want to support and the nations they should look for collaborations. It is, therefore, useful to look at the spatio-temporal trends of medical research prioritization to gain insight into popular and neglected areas of research as well as the allocation of prioritization of each nation. In this study, we develop a system that collects, classifies, and summarizes case report abstracts according to the location, time, and disease category of the report. The additional classifications allow us to visualize and monitor the trends in medical research prioritization by location, time, and disease category.

Exploring the Impact of the COVID-19 Pandemic on Twitter in Japan: Qualitative Analysis of Disrupted Plans and Consequences.

BACKGROUND: Despite being a pandemic, the impact of the spread of COVID-19 extends beyond public health, influencing areas such as the economy, education, work style, and social relationships. Research studies that document public opinions and estimate the long-term potential impact after the pandemic can be of value to the field. OBJECTIVE: This study aims to uncover and track concerns in Japan throughout the COVID-19 pandemic by analyzing Japanese individuals' self-disclosure of disruptions to their life plans on social media. This approach offers alternative evidence for identifying concerns that may require further attention for individuals living in Japan. METHODS: We extracted 300,778 tweets using the query phrase Corona-no-sei ("due to COVID-19," "because of COVID-19," or "considering COVID-19"), enabling us to identify the activities and life plans disrupted by the pandemic. The correlation between the number of tweets and COVID-19 cases was analyzed, along with an examination of frequently co-occurring words. RESULTS: The top 20 nouns, verbs, and noun plus verb pairs co-occurring with Corona no-sei were extracted. The top 5 keywords were graduation ceremony, cancel, school, work, and event. The top 5 verbs were disappear, go, rest, can go, and end. Our findings indicate that education emerged as the top concern when the Japanese government announced the first state of emergency. We also observed a sudden surge in anxiety about material shortages such as toilet paper. As the pandemic persisted and more states of emergency were declared, we noticed a shift toward long-term concerns, including careers, social relationships, and education. CONCLUSIONS: Our study incorporated machine learning techniques for disease monitoring through the use of tweet data, allowing the identification of underlying concerns (eg, disrupted education and work conditions) throughout the 3 stages of Japanese government emergency announcements. The comparison with COVID-19 case numbers provides valuable insights into the short- and long-term societal impacts, emphasizing the importance of considering citizens' perspectives in policy-making and supporting those affected by the pandemic, particularly in the context of Japanese government decision-making.

Differing Content and Language Based on Poster-Patient Relationships on the Chinese Social Media Platform Weibo: Text Classification, Sentiment Analysis, and Topic Modeling of Posts on Breast Cancer.

BACKGROUND: Breast cancer affects the lives of not only those diagnosed but also the people around them. Many of those affected share their experiences on social media. However, these narratives may differ according to who the poster is and what their relationship with the patient is; a patient posting about their experiences may post different content from someone whose friends or family has breast cancer. Weibo is 1 of the most popular social media platforms in China, and breast cancer-related posts are frequently found there. OBJECTIVE: With the goal of understanding the different experiences of those affected by breast cancer in China, we aimed to explore how content and language used in relevant posts differ according to who the poster is and what their relationship with the patient is and whether there are differences in emotional expression and topic content if the patient is the poster themselves or a friend, family member, relative, or acquaintance. METHODS: We used Weibo as a resource to examine how posts differ according to the different poster-patient relationships. We collected a total of 10,322 relevant Weibo posts. Using a 2-step analysis method, we fine-tuned 2 Chinese Robustly Optimized Bidirectional Encoder Representations from Transformers (BERT) Pretraining Approach models on this data set with annotated poster-patient relationships. These models were lined in sequence, first a binary classifier (no_patient or patient) and then a multiclass classifier (post_user, family_members, friends_relatives, acquaintances, heard_relation), to classify poster-patient relationships. Next, we used the Linguistic Inquiry and Word Count lexicon to conduct sentiment analysis from 5 emotion categories (positive and negative emotions, anger, sadness, and anxiety), followed by topic modeling (BERTopic). RESULTS: Our binary model (F1-score=0.92) and multiclass model (F1-score=0.83) were largely able to classify poster-patient relationships accurately. Subsequent sentiment analysis showed significant differences in emotion categories across all poster-patient relationships. Notably, negative emotions and anger were higher for the "no_patient" class, but sadness and anxiety were higher for the "family_members" class. Focusing on the top 30 topics, we also noted that topics on fears and anger toward cancer were higher in the "no_patient" class, but topics on cancer treatment were higher in the "family_members" class. CONCLUSIONS: Chinese users post different types of content, depending on the poster- poster-patient relationships. If the patient is family, posts are sadder and more anxious but also contain more content on treatments. However, if no patient is detected, posts show higher levels of anger. We think that these may stem from rants from posters, which may help with emotion regulation and gathering social support.

Exploring the use of AI text-to-image generation to downregulate negative emotions in an expressive writing application.

Conventional writing therapies are versatile, accessible and easy to facilitate online, but often require participants to self-disclose traumatic experiences. To make expressive writing therapies safer for online, unsupervised environments, we explored the use of text-to-image generation as a means to downregulate negative emotions during a fictional writing exercise. We developed a writing tool, StoryWriter, that uses Generative Adversarial Network models to generate artwork from users' narratives in real time. These images were intended to positively distract users from their negative emotions throughout the writing task. In this paper, we report the outcomes of two user studies: Study 1 (N = 388), which experimentally examined the efficacy of this application via negative versus neutral emotion induction and image generation versus no image generation control groups; and Study 2 (N = 54), which qualitatively examined open-ended feedback. Our results are heterogeneous: both studies suggested that StoryWriter somewhat contributed to improved emotion outcomes for participants with pre-existing negative emotions, but users' open-ended responses indicated that these outcomes may be adversely modulated by the generated images, which could undermine the therapeutic benefits of the writing task itself.

Natural Language Processing: from Bedside to Everywhere.

OBJECTIVES: Owing to the rapid progress of natural language processing (NLP), the role of NLP in the medical field has radically gained considerable attention from both NLP and medical informatics. Although numerous medical NLP papers are published annually, there is still a gap between basic NLP research and practical product development. This gap raises questions, such as what has medical NLP achieved in each medical field, and what is the burden for the practical use of NLP? This paper aims to clarify the above questions. METHODS: We explore the literature on potential NLP products/services applied to various medical/clinical/healthcare areas. RESULTS: This paper introduces clinical applications (bedside applications), in which we introduce the use of NLP for each clinical department, internal medicine, pre-surgery, post-surgery, oncology, radiology, pathology, psychiatry, rehabilitation, obstetrics, and gynecology. Also, we clarify technical problems to be addressed for encouraging bedside applications based on NLP. CONCLUSIONS: These results contribute to discussions regarding potentially feasible NLP applications and highlight research gaps for future studies.

AUTOMETA: Automatic Meta-Analysis System Employing Natural Language Processing.

Meta-analyses examine the results of different clinical studies to determine whether a treatment is effective or not. Meta-analyses provide the gold standard for medical evidence. Despite their importance, meta-analyses are time-consuming and this poses a challenge where timeliness is important. Research articles are also increasing rapidly and most meta-analyses become outdated after publication since they have not incorporated new evidence. Therefore, there is increasing interest to automate meta-analysis so as to speed up the process and allow for automatic update when new results are available. In this preliminary study we present AUTOMETA, our proposed system for automating meta-analysis which employs existing natural language processing methods for identifying Participants, Intervention, Control, and Outcome (PICO) elements. We show that our system can perform advanced meta-analyses by parsing numeric outcomes to identify the number of patients having certain outcomes. We also present a new dataset which improves previous datasets by incorporating additional tags to identify detailed information.

Monitoring Mentions of COVID-19 Vaccine Side Effects on Japanese and Indonesian Twitter: Infodemiological Study.

Background: The year 2021 was marked by vaccinations against COVID-19, which spurred wider discussion among the general population, with some in favor and some against vaccination. Twitter, a popular social media platform, was instrumental in providing information about the COVID-19 vaccine and has been effective in observing public reactions. We focused on tweets from Japan and Indonesia, 2 countries with a large Twitter-using population, where concerns about side effects were consistently stated as a strong reason for vaccine hesitancy. Objective: This study aimed to investigate how Twitter was used to report vaccine-related side effects and to compare the mentions of these side effects from 2 messenger RNA (mRNA) vaccine types developed by Pfizer and Moderna, in Japan and Indonesia. Methods: We obtained tweet data from Twitter using Japanese and Indonesian keywords related to COVID-19 vaccines and their side effects from January 1, 2021, to December 31, 2021. We then removed users with a high frequency of tweets and merged the tweets from multiple users as a single sentence to focus on user-level analysis, resulting in a total of 214,165 users (Japan) and 12,289 users (Indonesia). Then, we filtered the data to select tweets mentioning Pfizer or Moderna only and removed tweets mentioning both. We compared the side effect counts to the public reports released by Pfizer and Moderna. Afterward, logistic regression models were used to compare the side effects for the Pfizer and Moderna vaccines for each country. Results: We observed some differences in the ratio of side effects between the public reports and tweets. Specifically, fever was mentioned much more frequently in tweets than would be expected based on the public reports. We also observed differences in side effects reported between Pfizer and Moderna vaccines from Japan and Indonesia, with more side effects reported for the Pfizer vaccine in Japanese tweets and more side effects with the Moderna vaccine reported in Indonesian tweets. Conclusions: We note the possible consequences of vaccine side effect surveillance on Twitter and information dissemination, in that fever appears to be over-represented. This could be due to fever possibly having a higher severity or measurability, and further implications are discussed.

Clinical Comparable Corpus Describing the Same Subjects with Different Expressions.

Medical artificial intelligence (AI) systems need to learn to recognize synonyms or paraphrases describing the same anatomy, disease, treatment, etc. to better understand real-world clinical documents. Existing linguistic resources focus on variants at the word or sentence level. To handle linguistic variations on a broader scale, we proposed the Medical Text Radiology Report section Japanese version (MedTxt-RR-JA), the first clinical comparable corpus. MedTxt-RR-JA was built by recruiting nine radiologists to diagnose the same 15 lung cancer cases in Radiopaedia, an open-access radiological repository. The 135 radiology reports in MedTxt-RR-JA were shown to contain word-, sentence- and document-level variations maintaining similarity of contents. MedTxt-RR-JA is also the first publicly available Japanese radiology report corpus that would help to overcome poor data availability for Japanese medical AI systems. Moreover, our methodology can be applied widely to building clinical corpora without privacy concerns.

Exploring Relationships Between Tweet Numbers and Over-the-counter Drug Sales for Allergic Rhinitis: Retrospective Analysis.

BACKGROUND: Health-related social media data are increasingly being used in disease surveillance studies. In particular, surveillance of infectious diseases such as influenza has demonstrated high correlations between the number of social media posts mentioning the disease and the number of patients who went to the hospital and were diagnosed with the disease. However, the prevalence of some diseases, such as allergic rhinitis, cannot be estimated based on the number of patients alone. Specifically, individuals with allergic rhinitis typically self-medicate by taking over-the-counter (OTC) medications without going to the hospital. Although allergic rhinitis is not a life-threatening disease, it represents a major social problem because it reduces people's quality of life, making it essential to understand its prevalence and people's motives for self-medication behavior. OBJECTIVE: This study aims to explore the relationship between the number of social media posts mentioning the main symptoms of allergic rhinitis and the sales volume of OTC rhinitis medications in Japan. METHODS: We collected tweets over 4 years (from 2017 to 2020) that included keywords corresponding to the main nasal symptoms of allergic rhinitis: "sneezing," "runny nose," and "stuffy nose." We also obtained the sales volume of OTC drugs, including oral medications and nasal sprays, for the same period. We then calculated the Pearson correlation coefficient between time series data on the number of tweets per week and time series data on the sales volume of OTC drugs per week. RESULTS: The results showed a much higher correlation (r=0.8432) between the time series data on the number of tweets mentioning "stuffy nose" and the time series data on the sales volume of nasal sprays than for the other two symptoms. There was also a high correlation (r=0.9317) between the seasonal components of these time series data. CONCLUSIONS: We investigated the relationships between social media data and behavioral patterns, such as OTC drug sales volume. Exploring these relationships can help us understand the prevalence of allergic rhinitis and the motives for self-care treatment using social media data, which would be useful as a marketing indicator to reduce the number of out-of-stocks in stores, provide (sell) rhinitis medicines to consumers in a stable manner, and reduce the loss of sales opportunities. In the future, in-depth investigations are required to estimate sales volume using social media data, and future research could investigate other diseases and countries.

Measuring concerns about the COVID-19 vaccine among Japanese internet users through search queries.

With the increasing availability of the COVID-19 vaccines, vaccination has been rapidly promoted globally as a countermeasure against the spread of COVID-19. In Japan, vaccination was first introduced in February 2021. However, the amount of concern towards vaccination differs between individuals, and topics of concern include adverse reactions and side effects. This study investigated attitudes toward vaccines or vaccination during the COVID-19 pandemic across different Japanese prefectures, using Yahoo! JAPAN search queries. We first defined a vaccine concern index (VCI) by aggregating the search counts of vaccine-related queries from Yahoo! JAPAN users before examining VCI across all Japanese prefectures, accounting for gender and age. Our results demonstrated that VCI tended to be lower in more populated areas, and VCI was higher in their 20s to 40s than older people, especially in female users. Furthermore, there was a significant positive correlation (Spearman's Rank correlation coefficient [Formula: see text] = 0.60, [Formula: see text]) between VCI and prefectural vaccination rate, suggesting that web searching of adverse vaccine reactions may precede actual vaccination. This could reflect the information-seeking behavior of individuals who are accepting of vaccinations.

Modeling the spread of fake news on Twitter.

Fake news can have a significant negative impact on society because of the growing use of mobile devices and the worldwide increase in Internet access. It is therefore essential to develop a simple mathematical model to understand the online dissemination of fake news. In this study, we propose a point process model of the spread of fake news on Twitter. The proposed model describes the spread of a fake news item as a two-stage process: initially, fake news spreads as a piece of ordinary news; then, when most users start recognizing the falsity of the news item, that itself spreads as another news story. We validate this model using two datasets of fake news items spread on Twitter. We show that the proposed model is superior to the current state-of-the-art methods in accurately predicting the evolution of the spread of a fake news item. Moreover, a text analysis suggests that our model appropriately infers the correction time, i.e., the moment when Twitter users start realizing the falsity of the news item. The proposed model contributes to understanding the dynamics of the spread of fake news on social media. Its ability to extract a compact representation of the spreading pattern could be useful in the detection and mitigation of fake news.

Semantic Textual Similarity in Japanese Clinical Domain Texts Using BERT.

BACKGROUND: Semantic textual similarity (STS) captures the degree of semantic similarity between texts. It plays an important role in many natural language processing applications such as text summarization, question answering, machine translation, information retrieval, dialog systems, plagiarism detection, and query ranking. STS has been widely studied in the general English domain. However, there exists few resources for STS tasks in the clinical domain and in languages other than English, such as Japanese. OBJECTIVE: The objective of this study is to capture semantic similarity between Japanese clinical texts (Japanese clinical STS) by creating a Japanese dataset that is publicly available. MATERIALS: We created two datasets for Japanese clinical STS: (1) Japanese case reports (CR dataset) and (2) Japanese electronic medical records (EMR dataset). The CR dataset was created from publicly available case reports extracted from the CiNii database. The EMR dataset was created from Japanese electronic medical records. METHODS: We used an approach based on bidirectional encoder representations from transformers (BERT) to capture the semantic similarity between the clinical domain texts. BERT is a popular approach for transfer learning and has been proven to be effective in achieving high accuracy for small datasets. We implemented two Japanese pretrained BERT models: a general Japanese BERT and a clinical Japanese BERT. The general Japanese BERT is pretrained on Japanese Wikipedia texts while the clinical Japanese BERT is pretrained on Japanese clinical texts. RESULTS: The BERT models performed well in capturing semantic similarity in our datasets. The general Japanese BERT outperformed the clinical Japanese BERT and achieved a high correlation with human score (0.904 in the CR dataset and 0.875 in the EMR dataset). It was unexpected that the general Japanese BERT outperformed the clinical Japanese BERT on clinical domain dataset. This could be due to the fact that the general Japanese BERT is pretrained on a wide range of texts compared with the clinical Japanese BERT.

Estimation of Psychological Distress in Japanese Youth Through Narrative Writing: Text-Based Stylometric and Sentiment Analyses.

BACKGROUND: Internalizing mental illnesses associated with psychological distress are often underdetected. Text-based detection using natural language processing (NLP) methods is increasingly being used to complement conventional detection efforts. However, these approaches often rely on self-disclosure through autobiographical narratives that may not always be possible, especially in the context of the collectivistic Japanese culture. OBJECTIVE: We propose the use of narrative writing as an alternative resource for mental illness detection in youth. Accordingly, in this study, we investigated the textual characteristics of narratives written by youth with psychological distress; our research focuses on the detection of psychopathological tendencies in written imaginative narratives. METHODS: Using NLP tools such as stylometric measures and lexicon-based sentiment analysis, we examined short narratives from 52 Japanese youth (mean age 19.8 years, SD 3.1) obtained through crowdsourcing. Participants wrote a short narrative introduction to an imagined story before completing a questionnaire to quantify their tendencies toward psychological distress. Based on this score, participants were categorized into higher distress and lower distress groups. The written narratives were then analyzed using NLP tools and examined for between-group differences. Although outside the scope of this study, we also carried out a supplementary analysis of narratives written by adults using the same procedure. RESULTS: Youth demonstrating higher tendencies toward psychological distress used significantly more positive (happiness-related) words, revealing differences in valence of the narrative content. No other significant differences were observed between the high and low distress groups. CONCLUSIONS: Youth with tendencies toward mental illness were found to write more positive stories that contained more happiness-related terms. These results may potentially have widespread implications on psychological distress screening on online platforms, particularly in cultures such as Japan that are not accustomed to self-disclosure. Although the mechanisms that we propose in explaining our results are speculative, we believe that this interpretation paves the way for future research in online surveillance and detection efforts.

Predicting regional influenza epidemics with uncertainty estimation using commuting data in Japan.

Obtaining an accurate prediction of the number of influenza patients in specific areas is a crucial task undertaken by medical institutions. Infections (such as influenza) spread from person to person, and people are rarely confined to a single area. Therefore, creating a regional influenza prediction model should consider the flow of people between different areas. Although various regional flu prediction models have previously been proposed, they do not consider the flow of people among areas. In this study, we propose a method that can predict the geographical distribution of influenza patients using commuting data to represent the flow of people. To elucidate the complex spatial dependence relations, our model uses an extension of the graph convolutional network (GCN). Additionally, a prediction interval for medical institutions is proposed, which is suitable for cyclic time series. Subsequently, we used the weekly data of flu patients from health authorities as the ground-truth to evaluate the prediction interval and performance of influenza patient prediction in each prefecture in Japan. The results indicate that our GCN-based model, which used commuting data, considerably improved the predictive accuracy over baseline values both temporally and spatially to provide an appropriate prediction interval. The proposed model is vital in practical settings, such as in the decision making of public health authorities and addressing growth in vaccine demand and workload. This paper primarily presents a GCN as a useful means for predicting the spread of an epidemic.