Sub-Nyquist computational ghost imaging with deep learning.

We propose a deep learning computational ghost imaging (CGI) scheme to achieve sub-Nyquist and high-quality image reconstruction. Unlike the second-order-correlation CGI and compressive-sensing CGI, which use lots of illumination patterns and a one-dimensional (1-D) light intensity sequence (LIS) for image reconstruction, a deep neural network (DAttNet) is proposed to restore the target image only using the 1-D LIS. The DAttNet is trained with simulation data and retrieves the target image from experimental data. The experimental results indicate that the proposed scheme can provide high-quality images with a sub-Nyquist sampling ratio and performs better than the conventional and compressive-sensing CGI methods in sub-Nyquist sampling ratio conditions (e.g., 5.45%). The proposed scheme has potential practical applications in underwater, real-time and dynamic CGI.

Polygala tenuifolia: a source for anti-Alzheimer's disease drugs.

Context: Alzheimer's disease (AD) is a chronic neurodegenerative disease that originates from central nervous system lesions or recessions. Current estimates suggest that this disease affects over 35 million people worldwide. However, lacking effective drugs is the biggest handicap in treating AD. In traditional Chinese medicine (TCM), Polygala tenuifolia Willd. (Polygalaceae) is generally used to treat insomnia, memory dysfunction and neurasthenia.Objective: This review article explores the role of P. tenuifolia and its active components in anti-Alzheimer's disease.Methods: Literature for the last ten years was obtained through a search on PubMed, SciFinder, CNKI, Google Scholar, Web of Science, Science Direct and China Knowledge Resource Integrated with the following keywords: Polygala tenuifolia, polygalasaponin XXXII (PGS 32), tenuifolin, polygalacic acid, senegenin, tenuigenin, Alzheimer's disease.Results: Polygala tenuifolia and its active components have multiplex neuroprotective potential associated with AD, such as anti-Aß aggregation, anti-Tau protein, anti-inflammation, antioxidant, anti-neuronal apoptosis, enhancing central cholinergic system and promote neuronal proliferation.Conclusions: Polygala tenuifolia and its active components exhibit multiple neuroprotective effects. Hence, P. tenuifolia is a potential drug against Alzheimer's disease, especially in terms of prevention.

Progress on Active Analgesic Components and Mechanisms of Commonly Used Traditional Chinese Medicines: A Comprehensive Review.

Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients' suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug research. Non-opioid drugs are mainly used for the clinical treatment of mild to moderate pain, whereas opioid drugs are mainly used for treating moderate to severe pain. However, opioid drugs easily elicit adverse reactions, such as gastrointestinal discomfort, addiction, dependence, and so on. Traditional Chinese medicine and its active ingredients have unique advantages in the treatment of pain for quite a long time, and many analgesic drugs directly or indirectly were isolatiedfrom Chinese medicine or natural products, such as Liu Suan Yan Hu Suo Yi Su Pian and aspirin. With the development and modernization of research on herbal medicine more and more studies have been conducted on the active ingredients and mechanisms of traditional Chinese medicine analgesics. However, no review has been done on analgesic active components and their mechanisms. In this paper, 81 active components with clear chemical structure and definite analgesic effects in vivo and in vitro of traditional Chinese medicine and mechanisms of action reported in recent literatures are reviewed and summarized to provide reference for clinical analgesia and analgesics research.

[Progress on treatment of rheumatoid arthritis with ethnodrugs].

Rheumatoid arthritis(RA) is a chronic autoimmune disease, belonging to the "Arthromyodynia (Bi Zheng)" category in traditional Chinese medicine. However, the ethnomedicine has a unique understanding of RA, with a long-term clinical experience accumulation and significant efficacy in the treatment of RA, and it has now become one of the important means in treatment of RA. On the basis of literature research, the understanding of RA and commonly used Tibetan medicine, Mongolian medicine, Hui medicine and other herbs and preparations were reviewed in this paper, with the aim of providing a reference for its clinical treatment of RA and research and development of innovative drugs.

Design and Test of a Spatial Nanopositioner for Evaluating the Out-of-Focus-Plane Performance of Micro-Vision.

Micro-vision possesses high in-focus-plane motion tracking accuracy. Unfortunately, out-of-focus-plane displacements cannot be avoided, decreasing the in-focus-plane tracking accuracy of micro-vision. In this paper, a spatial nanopositioner is proposed to evaluate the out-of-focus-plane performance of a micro-vision system. A piezoelectric-actuated spatial multi-degree-of-freedom (multi-DOF) nanopositioner is introduced. Three in-plane Revolute-Revolute-Revolute-Revolute (RRRR) compliant parallel branched chains produce in-focus-plane motions. Three out-of-plane RRRR chains generate out-of-focus-plane motions. A typical micro-vision motion tracking algorithm is presented. A general grayscale template matching (GTM) approach is combined with the region of interest (ROI) method. The in-focus-plane motion tracking accuracy of the micro-vision system is tested. Different out-of-focus-plane displacements are generated using the proposed nanopositioner. The accuracy degradation of the in-focus-plane motion tracking is evaluated. The experimental results verify the evaluation ability of the proposed nanopositioner.

Design and Performance of a Spatial 6-RRRR Compliant Parallel Nanopositioning Stage.

Piezoelectric actuators (PEAs) and compliant parallel mechanisms (CPMs) are advantageous for designing nanopositioning stages (NPSs) with multiple degrees of freedom (multi-DOFs). This paper proposes a new NPS that uses PEAs and CPMs with multiple spatial DOFs. First, the design of the mechanism is introduced. Six parallel kinematics revolute-revolute-revolute-revolute (RRRR) branched chains were used to create a 6-RRRR CPM for superior mechanical performance. Three in-plane and three out-of-plane chains were combined using a two-in-one structure to ensure fabrication feasibility. A two-in-one 6-RRRR CPM was employed to build the proposed NPS. Second, the mechanical performance was analyzed. High-efficiency finite-element modeling approaches were derived using the compliance-based matrix method (CMM) and a pseudo-rigid body model (PRBM). The model included both 6-RRRR CPM and NPS. The simulation results validated the static and dynamic performance, and the experimental results verified the kinematics. Based on the newly designed mechanism and verified mechanical performance, the proposed 6-RRRR NPS contributes to the development of spatial multi-DOF NPSs using PEAs and CPMs.

The analgesic activities of total alkaloids of the ethnic medicine Cynanchum komarovii Al. Iljinski.

ETHNOPHARMACOLOGICAL RELEVANCE: Cynanchum komarovii Al. Iljinski is a ethnomedicinal herb and this ethno-medicine is used mainly to treat arthritis, toothache, reducing phlegm, relieving cough. Total alkaloids of Cynanchum komarovii Al. Iljinski (TACKI) is the main active compound of Cynanchum komarovii Al. Iljinski. Previous investigations have revealed that TACKI can significantly inhibit rat foot swelling caused by carrageenan; it has a significant inhibitory effect on granulation tissue proliferation. Pharmacology study showed that Cynanchum komarovii Al. Iljinski has analgesia, anti-inflammatory, antibacterial, anti-tumor, relieving cough and relieving asthma. However, there is no any investigation on the mechanism of analgesia and anti-inflammation. AIM OF THE STUDY: To clarify the analgesic effect and material basis of Cynanchum komarovii Al. Iljinski, determine the analgesic effect of TACKI, and provide experimental data support for its traditional application in the treatment of various pains. MATERIALS AND METHODS: TACKI were prepared by the traditional acid extraction and alkaline precipitation method, and TACKI was analyzed through classic animal models of acute antinociceptive animal models and chronic antinociceptive. Evaluation of analgesic effects, and preliminary discussion of the mechanism of its analgesic effects were performed in this work. RESULTS: Acute toxicity experiments showed that the LD50 of TACKI mice was 2960.88 mg/kg, and symptoms of poisoning appeared. Patholog of liver and kidney studies have shown that TACKI reduces eosinophils and increases basophils in kidney glomeruli. In the study of analgesic effects, TACKI had analgesic activity through the PWL, formalin test, and acetic acid writhing test. In the chronic inflammatory antinociceptive study, the latency of the withdrawal reflex in the TACKI group was prolonged, and the mechanical withdrawal reflex threshold was significantly increased. The protein expression of NMDA, GFAP and Iba-1 in rat brain tissue can be reduced significantly byTACKI. Meanwhile, the content of TNF-α and IL-6 in rat brain tissue is reduced. CONCLUSION: TACKI has a significant analgesic activities. It may be related to inhibiting the activation of astrocytes and reducing the content of inflammatory mediators.

Design and stiffness modeling of a four-degree-of-freedom nanopositioning stage based on six-branched-chain compliant parallel mechanisms.

Multi-degree-of-freedom (multi-DOF) nanopositioning stages (NPSs) have rapidly growing applications in the spatial micro-/nano-machining and manipulation. Compliant parallel mechanisms (CPMs) demonstrate advantages to achieve a large output stiffness and high payload. A four-DOF NPS based on six-branched-chain CPMs is proposed in this paper. First, a mechanism design approach is introduced. One primary vertical DOF is generated using three parallel-kinematic lever amplifiers. A three-revolute-revolute-revolute mechanism acts as the kinematic configuration to produce three secondary planar DOFs. Three types of single-axis and one type of double-axis notch flexure hinges (NFHs) are employed to realize the nanoscale displacement/movement guiding, transferring, and decoupling. Second, a stiffness modeling approach is derived. Combined with exact compliance matrices of 54 NFHs and 95 flexible beams, a four-DOF high-efficiency stiffness model of the six-branched-chain CPM is built. The calculation procedure of the whole input/output stiffnesses and coupling ratios takes 12.06 ms. Simulation and prototype test results validate the calculation accuracy. For example, the maximum calculation deviation of input stiffnesses is verified to be 4.52% and 8.18%, respectively. The two proposed approaches contribute to the statics parameter optimization of spatial multi-DOF NPSs.

Sophora alopecuroides L.: An ethnopharmacological, phytochemical, and pharmacological review.

ETHNOPHARMACOLOGICAL RELEVANCE: Sophora alopecuroides L., which is called Kudouzi in China, is a medicinal plant distributed in Western and Central Asia, especially in China, and has been used for decades to treat fever, bacterial infection, heart disease, rheumatism, and gastrointestinal diseases. AIM OF THE REVIEW: This review aims to provide up-to-date information on S. alopecuroides, including its botanical characterization, medicinal resources, traditional uses, phytochemistry, pharmacological research, and toxicology, in exploring future therapeutic and scientific potentials. MATERIALS AND METHODS: The information related to this article was systematically collected from the scientific literature databases including PubMed, Google Scholar, Web of Science, Science Direct, Springer, China National Knowledge Infrastructure, published books, PhD and MS dissertations, and other web sources, such as the official website of Flora of China and Yao Zhi website (https://db.yaozh.com/). RESULTS: A total of 128 compounds, such as alkaloids, flavonoids, steroids, and polysaccharides, were isolated from S. alopecuroides. Among these compounds, the effects of alkaloids, such as matrine and oxymatrine, were extensively studied and developed into new drugs. S. alopecuroides and its active components had a wide range of pharmacological activities, such as anticancer, antiviral, anti-inflammatory, antimicrobial, analgesic, and neuroprotective functions, as well as protective properties against pulmonary fibrosis and cardiac fibroblast proliferation. CONCLUSIONS: As an important traditional Chinese medicine, modern pharmacological studies have demonstrated that S. alopecuroides has prominent bioactivities, especially on gynecological inflammation and hepatitis B, and anticancer activities. These activities provide prospects for novel drug development for cancer and some chronic diseases. Nevertheless, the comprehensive evaluation, quality control, understanding of the multitarget network pharmacology, long-term in vivo toxicity, and clinical efficacy of S. alopecuroides require further detailed research.

Advances in Processing and Quality Control of Traditional Chinese Medicine Coptidis rhizoma (Huanglian): A Review.

Coptidis rhizoma (CR), also known as "Huanglian" in Chinese, is a traditional Chinese medicine commonly used in China, and it is an important species used in medicinal and food applications. It has been processed using a variety of methods, and the processed products have been widely used in clinical practice for thousands of years. However, few reports have focused on the systematic review of its processed products and quality control. In this study, a literature search on processing and quality control of CR was performed by using several literature resources including the Flora of China official website; various scientific databases such as PubMed, Google Scholar, the Web of Science, Science Direct, and China Knowledge Resource Integrated; and other web sources such as books and PhD and MS dissertations. Results showed that quality control for different processed products of CR received little or no attention. Its processing still followed ancient methods, and the quality of artifacts in different regions varied. Further attention should be paid to the study of processing technology and quality control with biomarkers. We suggest to establish a quality control mode based on traditional efficacy and with bioactive markers as detection indicators.