Detalhe da pesquisa
1.
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Regul Toxicol Pharmacol;
138: 105329, 2023 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36592682
2.
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Regul Toxicol Pharmacol;
138: 105339, 2023 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36649820
3.
Nonclinical Development of Biologics: Integrating Safety, Pharmacokinetics, and Pharmacodynamics to Create Smarter and More Flexible Nonclinical Safety Programs Optimizing Animal Use.
Int J Toxicol;
40(3): 270-284, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33631988
4.
Congenital Unilateral Renal Aplasia in a Cynomolgus Monkey (Macaca fascicularis) With Investigation Into Potential Pathogenesis.
Toxicol Pathol;
48(6): 766-783, 2020 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32815469
5.
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Regul Toxicol Pharmacol;
113: 104624, 2020 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32126256
6.
Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.
Regul Toxicol Pharmacol;
94: 91-100, 2018 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29355662
7.
Nonclinical safety testing of biopharmaceuticals--Addressing current challenges of these novel and emerging therapies.
Regul Toxicol Pharmacol;
73(1): 265-75, 2015 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26219199
8.
Biophotonic imaging in HO-1.luc transgenic mice: real-time demonstration of gender-specific chloroform induced renal toxicity.
Mutat Res;
574(1-2): 67-75, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15914208