Detalhe da pesquisa
1.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature;
618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37225977
2.
Development of selective inhibitors of phosphatidylinositol 3-kinase C2α.
Nat Chem Biol;
19(1): 18-27, 2023 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36109648
3.
Kinases charging to the membrane.
Cell;
143(6): 865-7, 2010 Dec 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21145452
4.
Activation of GCN2 by the ribosomal P-stalk.
Proc Natl Acad Sci U S A;
116(11): 4946-4954, 2019 03 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30804176
5.
A class of highly selective inhibitors bind to an active state of PI3Kγ.
Nat Chem Biol;
15(4): 348-357, 2019 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30718815
6.
The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism.
Biophys J;
119(11): 2205-2218, 2020 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33137306
7.
Synergy in activating class I PI3Ks.
Trends Biochem Sci;
40(2): 88-100, 2015 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25573003
8.
VPS34 complexes from a structural perspective.
J Lipid Res;
60(2): 229-241, 2019 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30397185
9.
Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi.
Nature;
501(7465): 116-20, 2013 Sep 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23913272
10.
Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division.
Mol Cell;
41(2): 186-96, 2011 Jan 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21255729
11.
Structure of lipid kinase p110ß/p85ß elucidates an unusual SH2-domain-mediated inhibitory mechanism.
Mol Cell;
41(5): 567-78, 2011 Mar 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21362552
12.
Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry.
Biochem J;
474(11): 1867-1877, 2017 05 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28381646
13.
Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling.
Biophys J;
113(11): 2396-2405, 2017 Dec 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29211993
14.
The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.
Biochem J;
473(2): 135-44, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26527737
15.
Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.
Biophys J;
110(8): 1811-1825, 2016 04 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27119641
16.
The structural basis for mTOR function.
Semin Cell Dev Biol;
36: 91-101, 2014 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25289568
17.
Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.
Biochemistry;
55(46): 6395-6405, 2016 Nov 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27933776
18.
PKCß phosphorylates PI3Kγ to activate it and release it from GPCR control.
PLoS Biol;
11(6): e1001587, 2013.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23824069
19.
Different inhibition of Gßγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gßγ-dependent regulator of PI3Kγ enzymatic activity.
Biochem J;
469(1): 59-69, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26173259
20.
The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.
Biochem J;
466(2): 359-67, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25495341