Detalhe da pesquisa
1.
Oral cinacalcet administration decreases serum ionized calcium and parathyroid hormone concentrations in healthy dogs.
J Vet Pharmacol Ther;
2024 Apr 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38563476
2.
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Nature;
549(7673): 523-527, 2017 09 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28959956
3.
Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression.
Am J Transplant;
22(11): 2571-2585, 2022 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35897156
4.
VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate.
Bioorg Med Chem Lett;
29(14): 1714-1718, 2019 07 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31113706
5.
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs.
Bioorg Med Chem Lett;
29(16): 2224-2228, 2019 08 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31248774
6.
Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway.
J Lipid Res;
59(5): 830-842, 2018 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29563219
7.
Prostatic collagen architecture in neutered and intact canines.
Prostate;
78(11): 839-848, 2018 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29740846
8.
Corrigendum to "Islet allografts expressing a PD-L1 and IDO fusion protein evade immune rejection and reverse preexisting diabetes in immunocompetent mice without systemic immunosuppression" [American Journal of Transplantation (2022) 2571-2585].
Am J Transplant;
23(5): 693, 2023 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36907701
9.
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1.
Bioorg Med Chem Lett;
28(6): 1043-1049, 2018 04 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29486970
10.
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.
Bioorg Med Chem Lett;
27(13): 2990-2995, 2017 07 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28522253
11.
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.
Bioorg Med Chem Lett;
27(2): 171-175, 2017 01 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27939174
12.
Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides.
Bioorg Med Chem Lett;
27(23): 5179-5184, 2017 12 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29089231
13.
Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.
Bioorg Med Chem Lett;
27(11): 2296-2301, 2017 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28442253
14.
Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem Lett;
26(1): 197-202, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26597534
15.
Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
Bioorg Med Chem Lett;
26(17): 4282-6, 2016 09 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27476142
16.
Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Bioorg Med Chem Lett;
26(13): 3029-3033, 2016 07 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27185330
17.
Treatment of Francisella philomiragia bacteremia in a dog.
J Vet Intern Med;
2024 May 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38738486
18.
Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184].
Bioorg Med Chem Lett;
28(17): 3014, 2018 09 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30076050
19.
No adverse consequences associated with targeting clinical signs to initiate antimicrobial treatment of postoperative subclinical bacteriuria in dogs following surgical decompression of Hansen type I thoracolumbar disk herniation.
J Am Vet Med Assoc;
261(1): 1-9, 2022 09 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36166501
20.
Autocrine effects of interleukin-6 mediate acute-phase proinflammatory and tissue-reparative transcriptional responses of canine bladder mucosa.
Infect Immun;
79(2): 708-15, 2011 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21115724