KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis.

Aberrant lysine lactylation (Kla) is associated with various diseases which are caused by excessive glycolysis metabolism. However, the regulatory molecules and downstream protein targets of Kla remain largely unclear. Here, we observed a global Kla abundance profile in colorectal cancer (CRC) that negatively correlates with prognosis. Among lactylated proteins detected in CRC, lactylation of eEF1A2K408 resulted in boosted translation elongation and enhanced protein synthesis which contributed to tumorigenesis. By screening eEF1A2 interacting proteins, we identified that KAT8, a lysine acetyltransferase that acted as a pan-Kla writer, was responsible for installing Kla on many protein substrates involving in diverse biological processes. Deletion of KAT8 inhibited CRC tumor growth, especially in a high-lactic tumor microenvironment. Therefore, the KAT8-eEF1A2 Kla axis is utilized to meet increased translational requirements for oncogenic adaptation. As a lactyltransferase, KAT8 may represent a potential therapeutic target for CRC.

Selective Construction of C-S/S-N Bonds from N-Substituted O-Thiocarbamates and Indoles under Transition-Metal-Free Conditions.

A method for the selective construction of S-N/C(sp2)-S bonds using N-substituted O-thiocarbamates and indoles as substrates is reported. This protocol features good atom utilization, mild conditions, short reaction time, and wide substrate scope, which can provide a convenient path for the functionalization of indoles. In addition, the reaction could be scaled up on gram scale, showing potential application value in industry synthesis.

MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.

INTRODUCTION: Membrane-associated guanylate kinase with an inverted domain structure-1 (MAGI1) is dysregulated in diabetes; however, its role in diabetic nephropathy (DN) remains unclear. In this study, we determined the function and associated mechanisms of MAGI1 in DN. METHODS: Serum samples from 28 patients with DN and 28 normal volunteers were collected. High-glucose (HG)-treated human renal mesangial cells (HRMCs) and streptozotocin-treated rats were used as cell and animal models of DN, respectively. MAGI1 mRNA expression was measured by quantitative reverse transcription polymerase chain reaction. An 5-Ethynyl-2'-deoxyuridine assay was used to assess cell proliferation, whereas Western blot analysis was performed to quantitate the levels of markers associated with proliferation, the extracellular matrix (ECM), and inflammation. These included collagens I, collagen IV, cyclin D1, AKT, phosphorylated-AKT (p-AKT), PI3K, and phosphorylated-PI3K (p-PI3K). The predicted binding of miR-205-5p with the MAGI1 3'UTR was verified using a luciferase assay. RESULTS: MAGI1 expression was increased in serum samples from DN patients and in HRMCs treated with HG. MAGI1 knockdown attenuated excessive proliferation, ECM accumulation, and inflammation in HG-induced HRMCs as well as injury to DN rats. MiR-205-5p potentially interacted with the 3'UTR of MAGI1 and binding was verified using a dual-luciferase reporter assay. Moreover, miR-205-5p repression offset the inhibitory influence of MAGI1 knockdown on proliferation, collagen deposition, and inflammation in HG-treated HRMCs. CONCLUSION: MAGI1 contributes to injury caused by DN. Furthermore, miR-205-5p binds to MAGI1 and suppresses MAGI1 function. These findings suggest that miR-205-5p-mediates MAGI1 inhibition, which represents a potential treatment for DN.

Response of phytoplankton community to dissolved organic matter composition and lake trophic state.

Human activities, intensified urbanization and climate changes altered source and quantity of dissolved organic matter (DOM), complicating its interaction with phytoplankton in aquatic ecosystems. However, relationship between DOM and phytoplankton in urban lakes strongly disturbed by human activities was still unclear. Thus, a whole-year sampling campaign was conducted in the Tangxun Lake, China's largest urban lake, to reveal the interaction between DOM and phytoplankton. Results indicated that trophic state in the Tangxun Lake varied from mesotrophic to moderately eutrophic. Parallel factor analysis method combined with excitation-emission matrix fluorescence spectroscopy revealed that DOM in the Tangxun Lake consisted of three components, two protein-like components (C1, C3), and one humic-like component (C2). Protein-like components occupied 80% ± 11% of total CDOM pool, mainly due to urbanization driving DOM to be more protein-like, less humic-like. Besides, DOM in the Tangxun Lake was mainly autochthonous input and more recently formed. Furthermore, a total of 129 phytoplankton species were identified, belonging to 78 genera and 7 phyla. Tangxun Lake's phytoplankton community structure was dominated by the Chlorophyta-Bacillariophyta-Cyanophyta type. The temporal succession of phytoplankton varied significantly. It was found that the abundance of Cryptophyta and Cyanophyta were predominant in the mesotrophic state, while Cyanophyta and Bacillariophyta were prevailing in the eutrophic and middle-eutrophic states. As for the interaction between DOM and phytoplankton, results demonstrated that phytoplankton biomass was significantly positively correlated with a (254), a proxy of DOM abundance. Moreover, phytoplankton abundance and biomass significantly positively correlated with autochthonous and freshly released DOM, indicating that the more autochthonous and freshly released DOM, the higher phytoplankton abundance and biomass. Overall, this study provides profound environmental implications for aquatic ecosystem management, especially those strongly affected by human activities.

Fibroblast-Derived Extracellular Vesicle-Packaged Long Noncoding RNA Upregulated in Diabetic Skin Enhances Keratinocyte MMP-9 Expression and Delays Diabetic Wound Healing.

Accurate communication between fibroblasts and keratinocytes is crucial for diabetic wound healing. Extracellular vesicles are being explored as essential mediators of intercellular communication in the skin. However, the mechanisms underlying wound healing mediated by fibroblast-derived extracellular vesicles (Fib-EVs) remain unclear. The present study evaluated the role of long noncoding RNA upregulated in diabetic skin (lnc-URIDS) packed in Fib-EVs in the wound healing of streptozotocin-induced diabetes and the potential mechanisms of the effects. We demonstrated that high glucose induced the enrichment of lnc-URIDS in Fib-EVs, facilitated the transfer of lnc-URIDS to primary rat epidermal keratinocytes, and increased the expression of matrix metalloproteinase-9. Mechanistically, the binding of lnc-URIDS to YTH domain family protein-2 enhanced the degradation of YTH domain family protein-2 in the lysosomes, which increased the translational activity of the messenger RNA of matrix metalloproteinase-9 and ultimately induced the degradation of collagen for wound healing. The results provided an insight into the crosstalk and cooperation between fibroblasts and keratinocytes in collagen homeostasis in diabetic wounds and clarified the mechanism by which lnc-URIDS degrades collagen for diabetic wound healing.

Interventions to Facilitate Shared Decision-Making Using Decision Aids with Coronary Heart Disease Patients: Systematic Review and Meta-Analysis.

Background: Coronary heart disease (CHD) is the leading cause of death in the world. There are some decision-making conflicts in the management of chest pain, treatment methods, stent selection, and other aspects due to the unstable condition of CHD in the treatment stage. Although using decision aids to facilitate shared decision-making (SDM) contributes to high-quality decision-making, it has not been evaluated in the field of CHD. This review systematically assessed the effects of SDM in patients with CHD. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials of SDM interventions in patients with CHD from database inception to 1 June 2022 (PROSPERO [Unique identifier: CRD42022338938]). We searched for relevant studies in the PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wan Fang databases. The primary outcomes were knowledge and decision conflict. The secondary outcomes were satisfaction, patient participation, trust, acceptance, quality of life, and psychological condition. Results: A total of 8244 studies were retrieved. After screening, ten studies were included in the analysis. Compared with the control group, SDM intervention with patient decision aids obviously improved patients' knowledge, decision satisfaction, participation, and medical outcomes and reduced decision-making conflict. There was no significant effect of SDM on trust. Conclusions: This study showed that SDM intervention in the form of decision aids was beneficial to decision-making quality and treatment outcomes among patients with CHD. The results of SDM interventions need to be evaluated in different environments.

Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts autophagy.

Diabetic foot ulcer is a life-threatening clinical problem in diabetic patients. Endothelial cell-derived small extracellular vesicles (sEVs) are important mediators of intercellular communication in the pathogenesis of several diseases. However, the exact mechanisms of wound healing mediated by endothelial cell-derived sEVs remain unclear. sEVs were isolated from human umbilical vein endothelial cells (HUVECs) pretreated with or without advanced glycation end products (AGEs). The roles of HUVEC-derived sEVs on the biological characteristics of skin fibroblasts were investigated both in vitro and in vivo We demonstrate that sEVs derived from AGEs-pretreated HUVECs (AGEs-sEVs) could inhibit collagen synthesis by activating autophagy of human skin fibroblasts. Additionally, treatment with AGEs-sEVs could delay the wound healing process in Sprague-Dawley (SD) rats. Further analysis indicated that miR-106b-5p was up-regulated in AGEs-sEVs and importantly, in exudate-derived sEVs from patients with diabetic foot ulcer. Consequently, sEV-mediated uptake of miR-106b-5p in recipient fibroblasts reduces expression of extracellular signal-regulated kinase 1/2 (ERK1/2), resulting in fibroblasts autophagy activation and subsequent collagen degradation. Collectively, our data demonstrate that miR-106b-5p could be enriched in AGEs-sEVs, then decreases collagen synthesis and delays cutaneous wound healing by triggering fibroblasts autophagy through reducing ERK1/2 expression.

Primary Typical Meningioma of the Sphenoid Sinus: A Case Report and Literature Review.

Primary cranial meningioma is extremely rare and only rarely described in clinical practice, as is primary sinus ectopic meningioma. We detailed the surgical management of a female patient, aged 83, who had a primary meningioma of the sphenoid sinus. This uncommon clinical entity was the subject of a study of the literature, and its prognosis was summarized. Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-024-04722-8.

The Excellent Mechanical Performance of Polymer-Coated Ceramsite Particles for Efficient Fracturing: An Explanation from a Surface, Tribological Perspective.

Hydraulic fracturing using micro-particles is an effective technology in the petroleum industry since the particles facilitate crack propagation of the shale layer, creating pathways for oil and gas. A new kind of polymer-coated ceramsite particles (PCP) was generated. The friction and wear properties of the particles under different loads and speeds were also studied. The tribological relationship between the newly fabricated polymer-coated ceramsite particles and the fracturing fluid was studied through tribological experiments under the condition of fracturing fluid lubrication. The results show that, in contrast, the wear of the new-generation particles is relatively stable, indicating that it has good adjustable friction properties. In addition, under the lubrication condition of fracturing fluid, the new-generation particles have better hydrophobicity, high-pressure resistance, and low reflux rate, which have an important value as a practical engineering application for improving shale gas production efficiency and production.

Mindfulness-based relapse prevention targeting psychological craving and trait mindfulness in young Chinese women with methamphetamine dependence: a randomized controlled trial.

Methods: We recruited 58 MA-dependent young adult females from a compulsory isolation drug rehabilitation center in Sichuan Province and randomly divided them into an MBRP group (n = 29) and a control group (n = 29) according to their degree of psychological craving. The MBRP group received 2 hours of MBRP training twice a week for 4 weeks, alongside routine treatment at the drug rehabilitation center. Meanwhile, the control group solely received routine treatment at the drug rehabilitation center without any additional interventions. The assessment was conducted before and immediately after the intervention, with the Compulsive Drug Use Scale (OCDUS) used to assess craving and the Five-Factor Mindfulness Scale (FFMQ) used to assess trait mindfulness. Also, a "mental feedback monitoring balance" instrument was used to assess concentration and relaxation during some training sessions. This randomized trial was conducted to evaluate the effectiveness of decreasing psychological craving and increasing trait mindfulness. Results: At baseline, there were no significant differences in total or dimension scores for FFMQ or OCDUS between the two groups (all P > 0.05). After the intervention, the repeated measures ANOVA showed a significant time main effect on changes in observing, non-judging, and non-reacting scores (all P < 0.05), and a significant interaction effect between time and group on both FFMQ total score and OCDUS score (P < 0.01 or P < 0.05). Mental feedback monitoring indicated significant improvement in concentration and relaxation after breath meditation exercises (P < 0.05 or P < 0.001). Additionally, the MBRP group showed improved relaxation during the body scan exercise (P < 0.01). Conclusion: MBRP training can improve the trait mindfulness of MA addicts and reduce psychological cravings effectively.

Conversion of Acids to S-Alkyl Dithiocarbamates by Decarboxylative Sulfuration Using Visible-Light Photocatalysis.

S-Alkyl dithiocarbamates, as an important class of sulfur-containing compounds, play pivotal roles in diverse fields, yet methods for the synthesis that start from simple, readily available feedstocks and exhibit mild conditions and structurally diverse products are scarce. In this work, we developed an efficient approach for the synthesis of various S-alkyl dithiocarbamates via visible-light photocatalysis with readily available and structurally diverse alkyl carboxylic acids (primary, secondary, and tertiary acids, amino acids, etc.) and disulfide tetraalkylthiuram as the starting materials. This protocol features high efficiency, mild reaction conditions, a broad substrate scope, and good functional group tolerance. Potential applications are further demonstrated by a sunlight experiment, H2O as a solvent, gram-scale synthesis, and facile synthesis of bioactive molecules.

Evolution characteristics and influencing factors of information network in Guangdong-Hong Kong-Macao Greater Bay Area.

In the context of the digital information era, the impact of "The Internet Plus," "Big Data," and other technologies on urban social development has been far beyond any preceding era, under the influence of information technology, urban agglomeration space exhibits a new layout. Based on the search engine data of eleven cities in the Guangdong-Hong Kong-Macao Greater Bay Area from 2012 to 2021, this research constructs the inter-city information network strength linkage matrix to examine the evolution characteristics of city network structure and its driving causes. The results reveal that (1) the overall information linkage strength exhibits a pattern of steadily growing the radiating effect from the leading cities of Guangdong, Shenzhen, and Hong Kong to the surrounding cities, and a closer and more balanced information linkage network is gradually built. (2) Guangzhou-Shenzhen-Hong Kong-Guangdong-Hong Kong-Macao Greater Bay Area information linkage absolute control advantage, four cities Foshan, Dongguan, Zhuhai, Macao regional hub position steadily highlighted. The entire information connection network of the urban agglomerations tends to be flat and polycentric at the same time. (3) The regional core-edge hierarchy is well established, with the four cities of Guangzhou, Dongguan, Shenzhen, and Hong Kong creating a northwest-southeast orientation. The core metropolis regions of Guangdong, Hong Kong, and Macao in the Greater Bay Area increasingly exert a radiation spreading effect to the northeast and southwest. (4) The urban economy, transportation distance, and information infrastructure have substantial effects on the information connection intensity network of urban clusters.

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Long-term occupation of coal gangue dumping sites (CGDS) may destroy ecological environment of nearby area. However, how the CGDS affects the distribution pattern of soil seed banks and vegetation in the nearby area is not clear. In this study, we investigated soil seed bank and vegetation at different distances from the second CGDS of Yangchangwan in Ningdong mining area, Lingwu, Ningxia. The results showed that soil seed bank was mainly distributed in 0-10 cm layer and decreased with increasing soil depth. Species richness of soil seed bank and vegetation first increased and then tended to be stable with increasing distance to the CGDS. The influence range of CGDS on soil seed banks was 300-500 m and was 100-300 m on aboveground vegetation. The CGDS did not affect the vertical distribution pattern of soil seed bank, but significantly affected the horizontal distribution pattern of soil seed banks and aboveground vegetation. The key area of vegetation restoration around the CGDS was between 100 m and 300 m.

Catalytic reduction of nitrogen monoxide using iron-nickel oxygen carriers derived from electroplating sludge: Novel method for the collaborative emission decrease of polluting gases.

The valorization of electroplating sludge (ES) for high added value presents greater economic and environmental benefits than conventional treatment methods such as thermal processing, solidification, and landfill. Inspired by the mechanism of chemical looping combustion (CLC), this study developed a novel cost-effective method for denitrification by preparing FeNi-OCs from ES to achieve the synergistic reduction of CO and NO emissions. The phase structure, micromorphology, and valence state changes of the FeNi-OC catalyst during the CO-catalyzed reduction of NO and the pathway for catalytic denitrification using FeNi-OCs were analyzed. Results showed that CO could reduce FeNi-OCs to FeNi, and the reduced FeNi was subsequently oxidized back to FeNi-OCs by NO, a process analogous to CLC. During experiments, the simultaneous consumption of CO and NO gases was observed at 350 °C. This phenomenon was highly pronounced at 600 °C, where the CO and NO concentrations decreased from initial values of 8550 and 470 ppm, respectively, to 6719 and 0 ppm, respectively, with conversion rates of 21.41 % and 100 %, respectively. Hence, synergistic emission reduction was achieved. Further experiments also indicated that the addition of 1.5 % ES during iron ore sintering could substantially reduce the CO and NO concentrations in the sintering flue gas from 1268.32 and 244.81 ppm, respectively, to 974.51 and 161.11 ppm, respectively.

Phosducin-like 3 is a novel prognostic and onco-immunological biomarker in glioma: A multi-omics analysis with experimental verification.

Malignant glioma is the most frequent primary tumor of the central nervous system. PDCL3 is a member of the phosducin-like protein family, and its imbalance has been shown to be associated with several human diseases. However, the underlying role of PDCL3 in human malignant cancers, especially in malignant gliomas, is unclear. In this study, we combined public database analysis and experimental verification to explore the differential expression, prognostic value and potential functions and mechanisms of PDCL3. The results revealed that PDCL3 is upregulated in multiple cancers and acts as a potential prognostic biomarker of glioma. Mechanistically, PDCL3 expression is associated with epigenetic modifications and genetic mutations. PDCL3 may directly interact with the chaperonin-containing TCP1 complex, regulating cell malignancy, cell communication and the extracellular matrix. More importantly, the association of PDCL3 with the infiltration of immune cells, immunomodulatory genes, immune checkpoints, cancer stemness and angiogenesis suggested that PDCL3 may regulate the glioma immune landscape. Furthermore, PDCL3 interference also decreased the proliferation, invasion and migration of glioma cells. In conclusion, PDCL3 is a novel oncogene and can be adopted as a biomarker with value in assisting clinical diagnosis, predicting patient outcomes and assessing the immune landscape of the tumor microenvironment in glioma.

Spatial-temporal differences and influencing factors of coupling coordination between urban quality and technology innovation in the Guangdong-Hong Kong-Macao Greater Bay Area.

The coordinated development of urban quality and technology innovation is an important element of China's technology innovation development strategy in the new era. Based on entropy TOPSIS, coupling coordination models, the gravity center and standard deviation ellipse method, the geographic probe, the GWR, and other methods, we explore the spatial variation and influencing factors of the coupling coordination relationship between urban quality and technology innovation in the Guangdong-Hong Kong-Macao Greater Bay Area from 2011 to 2020. It is found that: (1) the spatial distribution of the coupling coordination shows a characteristic of "high in the middle and low in the surroundings," and (2) the level of benign interaction in the central region is becoming more prominent. The center of gravity of coupling coordination moves toward the northeast, and the standard deviation ellipse shows a contraction trend away from the southwest. (3) Agglomeration capacity, human capital, cultural development, and infrastructure can significantly drive the improvement of the coupling coordination of urban quality and technology innovation, and the two-factor influence is significantly increased after the interaction. (4) The feedback effects of the coupling and coordination states of different cities on each factor have significant spatial differences and show the characteristics of hierarchical band distribution.

Brain network mechanism on cognitive control task in the elderly with brain aging: A functional near infrared spectroscopy study.

Objective: To study the brain network mechanism of cognitive control in the elderly with brain aging. Materials and methods: 21 normal young people and 20 elderly people were included in this study. Mini-mental State Examination and functional near-infrared spectroscopy (fNIRS) synchronous judgment test (including forward tests and reverse judgment tests) were performed on all subjects. To observe and compare differences in brain region activation and brain functional connectivity between subjects and forward and reverse trials by recording functional connectivity (FC) in different task paradigms and calculating bilateral prefrontal and primary motor cortical (PMC) areas. Results: In the forward and reverse judgment tests, the reaction time of the elderly group was significantly longer than the young group (P < 0.05), and there was no significant difference in the correct rate. In the homologous regions of interest (ROI) data, the FC of PMC and prefrontal cortex (PFC) in the elderly group was significantly decreased (P < 0.05). In the heterologous ROI data, except for left primary motor cortex (LPMC)-left prefrontal cortex (LPFC), the other PMC and PFC of the elderly group were significantly lower than the young group (P < 0.05) while processing the forward judgment test. However, the heterologous ROI data of LPMC-right prefrontal cortex (RPFC), LPMC-LPFC and RPFC-LPFC in the elderly group were significantly lower than the young group (P < 0.05) while processing the reverse judgment test. Conclusion: The results suggest that brain aging affected degeneration of whole brain function, which reduce the speed of information processing and form a brain network functional connection mode different from that of young people.

Development and validation of a glioma-associated mesenchymal stem cell-related gene prognostic index for predicting prognosis and guiding individualized therapy in glioma.

BACKGROUND: Recent studies have demonstrated that glioma-associated mesenchymal stem cells (GA-MSCs) are implicated in the regulation of glioma malignant progression. However, the prognostic value of GA-MSCs has not been comprehensively explored in glioma. METHODS: We extracted GA-MSCs from glioma tissues, established intracranial xenograft models in nude mice, and obtained GA-MSC-related genes (GA-MSCRGs) by using microarrays. The transcriptome data and clinical information of glioma patients were obtained from the CGGA and TCGA databases. We screened 8 prognostic GA-MSCRGs to construct a prognostic index by using the multivariate Cox regression method. The validity of the GA-MSCRGPI was verified in the training (CGGA693) and validation (TCGA and CGGA325) cohorts. The expression patterns of these 8 GA-MSCRGs were validated in 78 glioma tissue specimens by using a qRT‒PCR assay. RESULTS: GA-MSCs were successfully isolated from glioma tissues. Based on intracranial xenograft models and transcriptome microarray screening, 8 genes (MCM7, CDK6, ORC1, CCL20, TNFRSF12A, POLA1, TRAF1 and TIAM1) were selected for the construction of a GA-MSC-related gene prognostic index (GA-MSCRGPI). In both the training and validation cohorts, high GA-MSCRGPI patients showed an inferior survival outcome compared with low GA-MSCRGPI patients. A nomogram was established based on independent prognostic indicators (age, WHO grade and GA-MSCRGPI) and exhibited a strong forecasting ability for overall survival (OS). Moreover, we found that the GA-MSCRGPI could evaluate the prognosis of glioma patients undergoing chemoradiotherapy. The high GA-MSCRGPI group exhibited higher immune, stromal and ESTIMATE scores; lower tumor purity; higher infiltration of Tregs and M2-type macrophages; fewer activated NK cells; and higher expression of immune checkpoints. Tumor Immune Dysfunction and Exclusion (TIDE) showed that the high GA-MSCRGPI group had more responders to ICI therapy. The results of the genetic mutation profile and tumor mutation burden (TMB) in different GA-MSCRGPI subgroups further supplement GA-MSCRGPI-related mechanisms. Finally, the expression patterns of 8 selected GA-MSCRGs in GA-MSCRGPI were correlated with glioma WHO grades to a certain extent. CONCLUSION: The constructed GA-MSCRGPI could predict prognosis and guide individualized therapy in glioma patients.

Venation-Mimicking, Ultrastretchable, Room-Temperature-Attachable Metal Tapes for Integrated Electronic Skins.

Future electronic skin systems require stretchable conductors and low-temperature integration of external components, which remains challenging for traditional metal films. Herein, a bioinspired design concept is reported to endow metal films with 200% stretchability as well as room-temperature integration capability with diverse components. It is revealed that by controllable implantation of defects, distinctive venation-mimicking cracking modes can be induced in strained metal films, leading to profound stretchability regulation. An intriguing exponential-to-linear transition of the film electromechanical performance is observed, which is elucidated by a unified model covering the essence of all modes. Combined with room-temperature integration capability, an integrated electronic skin is constructed with metal films serving as stretchable electrodes, diverse sensors, and "tapes" to attach subcomponents, showing prospects in helping disabled people. This one-step, defect implantation strategy is applicable to common metals without special substrate treatments, which enables fascinating ultrastretchable metal film conductors with low-temperature integration capability to spark more sophisticated flexible electronic systems.

High-speed directional transport of condensate droplets on superhydrophobic saw-tooth surfaces.

HYPOTHESIS: Most droplets on high-efficiency condensing surfaces have radii of less than 100 µm, but conventional droplet transport methods (such as wettability-gradient surfaces and structural-curvature-gradient surfaces) that rely on the unbalanced force of three-phase lines can only transport millimeter-sized droplets efficiently. Regulating high-speed directional transport of condensate droplets is still challenging. Therefore, we present a method for condensate droplet transportation, based on the reaction force of the superhydrophobic saw-tooth surfaces to the liquid bridge, the condensate droplets could be transported at high speed and over long distances. EXPERIMENTS: The superhydrophobic saw-tooth surfaces are fabricated by femtosecond laser ablation and chemical etching. Condensation experiments and luminescent particle characterization experiments on different surfaces are conducted. Aided by the theoretical analysis, we illustrate the remarkable performance of condensate droplet transportation on saw-tooth surfaces. FINDINGS: Compared with conventional methods, our method improves the transport velocity and relative transport distance by 1-2 orders of magnitude and achieves directional transport of the smallest condensate droplet of about 2 µm. Furthermore, the superhydrophobic saw-tooth surfaces enable multi-hop directional jumping of condensate droplets, leading to cross-scale increases in transport distances from microns to decimeters.