Detalhe da pesquisa
1.
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell;
184(4): 943-956.e18, 2021 02 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33571432
2.
Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc Natl Acad Sci U S A;
120(39): e2308435120, 2023 09 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37733739
3.
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Nat Chem Biol;
18(8): 831-840, 2022 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35637350
4.
Discovery of (S)-3-(4-(benzyloxy)phenyl)-2-(2-phenoxyacetamido)propanoic acid derivatives as a new class of GPR34 antagonists.
Bioorg Med Chem Lett;
97: 129548, 2024 01 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37949379
5.
Discovery of 5-((1H-indazol-3-yl) methylene)-2-thioxoimidazolidin-4-one derivatives as a new class of AHR agonists with anti-psoriasis activity in a mouse model.
Bioorg Med Chem Lett;
92: 129383, 2023 08 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37348572
6.
Discovery of 3-phenyl-1,2,4-oxadiazole derivatives as a new class of SARS-CoV-2 main protease inhibitors.
Bioorg Med Chem Lett;
86: 129238, 2023 04 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36924946
7.
Discovery of benzodiazepine derivatives as a new class of covalent inhibitors of SARS-CoV-2 main protease.
Bioorg Med Chem Lett;
92: 129407, 2023 08 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37437852
8.
Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy.
Bioorg Med Chem Lett;
74: 128911, 2022 10 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35907606
9.
Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors.
Bioorg Med Chem Lett;
63: 128651, 2022 05 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35245663
10.
Discovery of Small Molecule Agonist of Gonadotropin-Releasing Hormone Receptor (GnRH1R).
J Chem Inf Model;
62(20): 5009-5022, 2022 Oct 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36184840
11.
C3 ester side chain plays a pivotal role in the antitumor activity of Maytansinoids.
Biochem Biophys Res Commun;
566: 197-203, 2021 08 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34144258
12.
Discovery of 3,6-disubstutited-imidazo[1,2-a]pyridine derivatives as a new class of CLK1 inhibitors.
Bioorg Med Chem Lett;
41: 127881, 2021 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33662541
13.
Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.
Angew Chem Int Ed Engl;
60(16): 8760-8765, 2021 04 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33511756
14.
Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors.
Bioorg Med Chem Lett;
29(18): 2595-2603, 2019 09 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31400941
15.
A base-promoted cascade reaction of α,ß-unsaturated N-tosylhydrazones with o-hydroxybenzyl alcohols: highly regioselective synthesis of N-sec-alkylpyrazoles.
Org Biomol Chem;
17(37): 8561-8570, 2019 09 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31513227
16.
Metal-Free Ring-Expansion Reaction of Six-membered Sulfonylimines with Diazomethanes: An Approach toward Seven-Membered Enesulfonamides.
Angew Chem Int Ed Engl;
55(4): 1441-4, 2016 Jan 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26663740
17.
Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway.
Int Immunopharmacol;
127: 111314, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38081102
18.
Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo.
Biochem Pharmacol;
224: 116217, 2024 Apr 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38641306
19.
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain.
J Med Chem;
66(5): 3460-3483, 2023 03 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36821347
20.
Discovery and structure-activity relationship studies of novel α-ketoamide derivatives targeting the SARS-CoV-2 main protease.
Eur J Med Chem;
259: 115657, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37517202