Object detection: A novel AI technology for the diagnosis of hepatocyte ballooning.

Metabolic dysfunction-associated fatty liver disease (MAFLD) has reached epidemic proportions worldwide and is the most frequent cause of chronic liver disease in developed countries. Within the spectrum of liver disease in MAFLD, steatohepatitis is a progressive form of liver disease and hepatocyte ballooning (HB) is a cardinal pathological feature of steatohepatitis. The accurate and reproducible diagnosis of HB is therefore critical for the early detection and treatment of steatohepatitis. Currently, a diagnosis of HB relies on pathological examination by expert pathologists, which may be a time-consuming and subjective process. Hence, there has been interest in developing automated methods for diagnosing HB. This narrative review briefly discusses the development of artificial intelligence (AI) technology for diagnosing fatty liver disease pathology over the last 30 years and provides an overview of the current research status of AI algorithms for the identification of HB, including published articles on traditional machine learning algorithms and deep learning algorithms. This narrative review also provides a summary of object detection algorithms, including the principles, historical developments, and applications in the medical image analysis. The potential benefits of object detection algorithms for HB diagnosis (specifically those combined with a transformer architecture) are discussed, along with the future directions of object detection algorithms in HB diagnosis and the potential applications of generative AI on transformer architecture in this field. In conclusion, object detection algorithms have huge potential for the identification of HB and could make the diagnosis of MAFLD more accurate and efficient in the near future.

International clinical practice guideline on the use of traditional Chinese medicine for ulcerative colitis by Board of Specialty Committee of Digestive System Disease of World Federation of Chinese Medicine Societies (2023).

Ulcerative colitis (UC), a chronic and nonspecific inflammatory disease of the intestine, has become a prevalent global health concern. This guideline aims to equip clinicians and caregivers with effective strategies for the treatment and management of adult UC patients using traditional Chinese medicine (TCM). The guideline systematically evaluated contemporary evidence through the Grading of Recommendations Assessment, Development, and Evaluation framework. Additionally, it incorporated insights from ancient Chinese medical sources, employing the evidence grading method found in traditional TCM literature. The development process involved collaboration with multidisciplinary experts and included input from patients with UC. The guideline, based on a comprehensive review of available evidence, present 40 recommendations. They offer a condensed overview of TCM's role in understanding the pathogenesis, diagnosis, and treatment of UC, along with an assessment of the efficacy of various TCM-based treatments. TCM exhibits promising outcomes in the treatment of UC. However, to establish its efficacy conclusively, further high-quality clinical studies on TCM for UC are essential.

Wide-angle high-efficiency absorption of graphene empowered by an angle-insensitive Tamm plasmon polariton.

In recent years, researchers utilized Tamm plasmon polaritons (TPPs) in conventional heterostructures composed of a metal layer, a dielectric spacer layer and an all-dielectric one-dimensional (1-D) photonic crystal (PhC) to achieve high-efficiency absorption of graphene. According to the Bragg scattering theory, photonic bandgaps (PBGs) in all-dielectric 1-D PhC strongly shift toward shorter wavelengths (i.e., blueshift) as the incident angle increases. Therefore, TPPs in conventional heterostructures also show strongly blueshift property. Such strongly blueshift property of TPPs greatly limits the operating angle range of the high-efficiency absorption of graphene. Herein, we realize an angle-insensitive TPP in a heterostructure composed of a metal layer, a dielectric spacer layer and a 1-D PhC containing hyperbolic metamaterial layers. Empowered by the angle-insensitive property of the TPP, we achieve wide-angle high-efficiency absorption of graphene. The operating angle range (A > 80%) reaches 41.8 degrees, which is much larger than those in the reported works based on TPPs and defect modes. Our work provides a viable route to designing cloaking devices and photodetectors.

Anomalous polarization-sensitive Fabry-Perot resonance in a one-dimensional photonic crystal containing an all-dielectric metamaterial defect.

Owing to polarization-independent property of propagating phases inside isotropic dielectric layers, Fabry-Perot resonances in metal-dielectric-metal sandwich structures and one-dimensional (1-D) photonic crystals (PhCs) with isotropic dielectric defects are polarization-insensitive. Herein, we introduce an all-dielectric elliptical metamaterial (EMM) defect into a 1-D PhC to realize an anomalous polarization-sensitive Fabry-Perot resonance empowered by the polarization-sensitive property of the propagating phase inside the all-dielectric EMM layer. The wavelength difference of the Fabry-Perot resonance between transverse magnetic and transverse electric polarizations is larger than 100 nm at the incident angle of 45 degrees. Enabled by the polarization-sensitive property of the Fabry-Perot resonance, high-performance polarization selectivity can be achieved in a broad angle range. Our work offers a viable recipe, well within the reach of current fabrication technique, to explore polarization-dependent physical phenomena and devices.

Anomalous polarization-sensitive Fabry-Perot resonance in a one-dimensional photonic crystal containing an all-dielectric metamaterial defect: erratum.

This erratum corrects some typing errors of our original paper, Opt. Express31(20), 32669 (2023)10.1364/OE.499830. The correction does not affect the results of the original paper.

Enhancing Faraday and Kerr rotations based on the toroidal dipole mode in an all-dielectric magneto-optical metasurface.

The magneto-optical Faraday and Kerr effects are widely used in modern optical devices. In this Letter, we propose an all-dielectric metasurface composed of perforated magneto-optical thin films, which can support the highly confined toroidal dipole resonance and provide full overlap between the localized electromagnetic field and the thin film, and consequently enhance the magneto-optical effects to an unprecedented degree. The numerical results based on the finite element method show that the Faraday and Kerr rotations can reach -13.59° and 8.19° in the vicinity of toroidal dipole resonance, which are 21.2 and 32.8 times stronger than those in the equivalent thickness of thin films. In addition, we design an environment refractive index sensor based on the resonantly enhanced Faraday and Kerr rotations, with sensitivities of 62.96 nm/RIU and 73.16 nm/RIU, and the corresponding maximum figures of merit 132.22°/RIU and 429.45°/RIU, respectively. This work provides a new, to the best of our knowledge, strategy for enhancing the magneto-optical effects at nanoscale, and paves the way for the research and development of magneto-optical metadevices such as sensors, memories, and circuits.

Hepatocytic ballooning in non-alcoholic steatohepatitis: Dilemmas and future directions.

Hepatocytic ballooning is a key histological feature in the diagnosis of non-alcoholic steatohepatitis (NASH) and is an essential component of the two most widely used histological scoring systems for diagnosing and staging non-alcoholic fatty liver disease (NAFLD) [namely, the NAFLD activity score (NAS), and the steatosis, activity and fibrosis (SAF) scoring system]. As a result of the increasing incidence of NASH globally, the diagnostic challenges of hepatocytic ballooning are unprecedented. Despite the clear pathological concept of hepatocytic ballooning, there are still challenges in assessing hepatocytic ballooning in 'real life' situations. Hepatocytic ballooning can be confused with cellular oedema and microvesicular steatosis. Significant inter-observer variability does exist in assessing the presence and severity of hepatocytic ballooning. In this review article, we describe the underlying mechanisms associated with hepatocytic ballooning. Specifically, we discuss the increased endoplasmic reticulum stress and the unfolded protein response, as well as the rearrangement of the intermediate filament cytoskeleton, the appearance of Mallory-Denk bodies and activation of the sonic Hedgehog pathway. We also discuss the use of artificial intelligence in the detection and interpretation of hepatocytic ballooning, which may provide new possibilities for future diagnosis and treatment.

Polarization-sensitive photonic bandgaps in hybrid one-dimensional photonic crystals composed of all-dielectric elliptical metamaterials and isotropic dielectrics.

Photonic bandgaps (PBGs) in conventional one-dimensional (1-D) photonic crystals (PhCs) composed of isotropic dielectrics are polarization-insensitive since the optical length within a isotropic dielectric layer is polarization-independent. Herein, we realize polarization-sensitive PBGs in hybrid 1-D PhCs composed of all-dielectric elliptical metamaterials (EMMs) and isotropic dielectrics. Based on the Bragg scattering theory and iso-frequency curve analysis, an analytical model is established to characterize the angle dependence of PBGs under transverse magnetic and transverse electric polarizations. The polarization-dependent property of PBGs can be flexibly controlled by the filling ratio of one of the isotropic dielectrics within all-dielectric EMMs. Assisted by the polarization-sensitive PBGs, high-performance polarization selectivity can be achieved. Our work offers a loss-free platform to achieve polarization-sensitive physical phenomena and optical devices.

A Near-Infrared Fluorescent Probe for Recognition of Hypochlorite Anions Based on Dicyanoisophorone Skeleton.

A novel near-infrared (NIR) fluorescent probe (SWJT-9) was designed and synthesized for the detection of hypochlorite anion (ClO-) using a diaminomaleonitrile group as the recognition site. SWJT-9 had large Stokes shift (237 nm) and showed an excellent NIR fluorescence response to ClO- with the color change under the visible light. It showed a low detection limit (24.7 nM), high selectivity, and rapid detection (within 2 min) for ClO-. The new detection mechanism of SWJT-9 on ClO- was confirmed by 1H NMR, MS spectrum, and the density functional theory (DFT) calculations. In addition, the probe was successfully used to detect ClO- in HeLa cells.

Robust enhancement of high-harmonic generation from all-dielectric metasurfaces enabled by polarization-insensitive bound states in the continuum.

The emerging all-dielectric platform exhibits high-quality (Q) resonances governed by the physics of bound states in the continuum (BIC) that drives highly efficient nonlinear optical processes. Here we demonstrate the robust enhancement of third-(THG) and fifth-harmonic generation (FHG) from all-dielectric metasurfaces composed of four silicon nanodisks. Through the symmetry breaking, the genuine BIC transforms into the high-Q quasi-BIC resonance with tight field confinement for record high THG efficiency of 3.9 × 10-4 W-2 and FHG efficiency of 4.8 × 10-10 W-4 using a moderate pump intensity of 1 GW/cm2. Moreover, the quasi-BIC and the resonantly enhanced harmonics exhibit polarization-insensitive characteristics due to the special C4 arrangement of meta-atoms. Our results suggest the way for smart design of efficient and robust nonlinear nanophotonic devices.

Photonic bandgap engineering in hybrid one-dimensional photonic crystals containing all-dielectric elliptical metamaterials.

Metamaterials with negative permittivities or/and permeabilities greatly enrich photonic bandgap (PBG) engineering in one-dimensional (1-D) photonic crystals (PhCs). Nevertheless, their inevitable optical losses strongly destroy the crucial prohibition characteristic of PBGs, which makes such engineered PBGs not utilizable in some relevant physical processes and optical/optoelectronic devices. Herein, we bridge a link between 1-D PhCs and all-dielectric loss-free metamaterials and propose a hybrid 1-D PhC containing all-dielectric elliptical metamaterials to engineer angle-dependence of PBGs. Associating the Bragg scattering theory with the iso-frequency curve analysis, an analytical model is established to precisely describe the angle-dependence of PBG. Based on the analytical model, two types of special PBGs, i.e., angle-insensitive and angle-sensitive PBGs, are designed. By further introducing defects into the designed 1-D PhCs, angle-dependence of defect modes can also be flexibly controlled. Our protocol opens a viable route to precisely engineering PBGs and promotes the development of PBG-based physics and applications.

Wide-angle polarization selectivity based on anomalous defect mode in photonic crystal containing hyperbolic metamaterials.

Conventional defect modes in all-dielectric 1D photonic crystals (PCs) are polarization-insensitive. This poses a great challenge in achieving high-performance polarization selectivity. In this Letter, we introduce a defect layer into a 1D PC containing hyperbolic metamaterials to achieve an anomalous defect mode with polarization-sensitive characteristics. As the incident angle increases, such a defect mode remains almost unshifted under transverse magnetic polarization, while strongly shifting toward shorter wavelengths under transverse electric polarization. The polarization-sensitive characteristics of the defect mode can be well explained by the Fabry-Perot resonance condition. Assisted by the polarization-sensitive defect mode, wide-angle polarization selectivity with an operating angle width up to 54.8° can be realized. Our work provides a route to designing wide-angle linear polarizers using simple 1D structures, which would be useful in liquid crystal display and Q-switched lasers.

Manipulating the optical beam width in topological pseudospin-dependent waveguides using all-dielectric photonic crystals.

We propose a width-tunable topological pseudospin-dependent waveguide (TPDW) which can manipulate the optical beam width using a heterostructure of all-dielectric photonic crystals (PhCs). The heterostructure can be realized by introducing a PhC featuring double Dirac cones into the other two PhCs with different topological indices. The topological pseudospin-dependent waveguide states (TPDWSs) achieved from the TPDW exhibit unidirectional transport and immunity against defects. As a potential application of our work, using these characteristics of TPDWSs, we further design a topological pseudospin-dependent beam expander which can expand a narrow beam into a wider one at the communication wavelength of 1.55 µm and is robust against three kinds of defects. The proposed TPDW with widely adjustable width can better dock with other devices to achieve stable and efficient transmission of light. Meanwhile, all-dielectric PhCs have negligible losses at optical wavelengths, which provides the prospect of broad application in photonic integrated devices.

Endoscopic submucosal dissection for colorectal lesions: outcomes from a United States experience.

BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) is commonly used in Asia for resection of large non-pedunculated colorectal polyps (LNPCPs) and early (T1) colorectal cancers. It allows for en bloc removal and is often curative. We describe outcomes of colorectal ESD from a United States (US) academic medical center and compare this to international experiences. METHODS: Retrospective review was performed of colonic lesions referred to the University of Chicago Medical Center for ESD from 2012 to 2020. Clinical and procedural data were collected. RESULTS: The study included 78 lesions with mean size of 29.7 mm (range 10-100 mm). The overall en bloc resection rate was 73.1% (n = 57). Between the first and second half of the study, it improved from 61.5 to 84.6% (p = 0.02). Histology showed adenocarcinoma in fifteen lesions (19.2%). Of all neoplastic lesions (n = 68), resection with negative margins (R0) was achieved in 54 cases (79.4%). Adverse events occurred in 9 cases (11.5%), but most (n = 6, 66.7%) were successfully treated endoscopically. Follow-up endoscopy was performed in 46 patients (59.0%) at a mean interval of 6.8 months (SD ± 5.0 months) with two case of recurrent lesion (4.3%). CONCLUSIONS: This study shows successful colorectal ESD outcomes at a US tertiary center. The en bloc resection rate was lower than other cohorts, but a learning curve was demonstrated. The R0 resection, lesion recurrence, and adverse event rates were similar to other non-Asian experiences, but not as favorable as in Asia [Fuccio et al. in Gastrointest Endosc 86:74-86.e17, 2017]. Increased ESD training in the US can help optimize utilization and outcomes.

The Pyroptosis-Related Gene Prognostic Index Associated with Tumor Immune Infiltration for Pancreatic Cancer.

Pancreatic cancer (PC) is one of the most fatal malignancies. Pyroptosis, a type of inflammatory cell death, likely plays a critical role in the development and progression of tumors. However, the relationship between pyroptosis-related genes (PRGs) and prognosis and immunity to PC is not entirely clear. This study, aimed at identifying the key PRGs in PC, highlights their prognostic value, immune characteristics, and candidate drugs for therapies. We screened 47 differentially expressed PRGs between PC and normal pancreas tissues from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) datasets. Afterwards, a pyroptosis-related gene prognostic index (PRGPI) was constructed based on eight PRGs (AIM2, GBP1, HMGB1, IL18, IRF6, NEK7, NLRP1 and PLCG1) selected by univariate and multivariate Cox regression analysis and LASSO regression analysis, and verified in two external datasets from the International Cancer Genome Consortium (ICGC) and Gene Expression Omnibus (GEO) databases. We found that the PC patients in the PRGPI-defined subgroups not only reflected significantly different levels of infiltration in a variety of immune cells, such as M1 macrophages, but also showed differential expression in genes of the human leukocyte antigen (HLA) family and immune checkpoints. Additionally, molecular characteristics and drug sensitivity also stayed close to the PRGPI risk scores. Therefore, PRGPI may serve as a valuable prognostic biomarker and may potentially provide guidance toward novel therapeutic options for PC patients.

Tailoring anisotropic absorption in a borophene-based structure via critical coupling.

The research of two-dimensional (2D) materials with atomic-scale thicknesses and unique optical properties has become a frontier in photonics and electronics. Borophene, a newly reported 2D material, provides a novel building block for nanoscale materials and devices. We present a simple borophene-based absorption structure to boost the light-borophene interaction via critical coupling in the visible wavelengths. The proposed structure consists of borophene monolayer deposited on a photonic crystal slab backed with a metallic mirror. The numerical simulations and theoretical analysis show that the light absorption of the structure can be remarkably enhanced as high as 99.80% via critical coupling mechanism with guided resonance, and the polarization-dependent absorption behaviors are demonstrated due to the strong anisotropy of borophene. We also examine the tunability of the absorption behaviors by adjusting carrier density and lifetime of borophene, air hole radius in the slab, the incident angle and polarization angle. The proposed absorption structure provides novel access to the flexible and effective manipulation of light-borophene interactions in the visible and shows a good prospect for the future borophene-based electronic and photonic devices.

Broadband wide-angle multilayer absorber based on a broadband omnidirectional optical Tamm state.

Recently, broadband optical Tamm states (OTSs) in heterostructures composed of highly lossy metal layers and all-dielectric one-dimensional (1D) photonic crystals (PhCs) have been utilized to realize broadband absorption. However, as the incident angle increases, the broadband OTSs in such heterostructures shift towards shorter wavelengths along the PBGs in all-dielectric 1D PhCs, which strongly limits the bandwidths of wide-angle absorption. In this paper, we realize a broadband omnidirectional OTS in a heterostructure composed of a Cr layer and a 1D PhC containing layered hyperbolic metamaterials with an angle-insensitive photonic band gap. Assisted by the broadband omnidirectional OTS, broadband wide-angle absorption can be achieved. High absorptance (A > 0.85) can be remained when the wavelength ranges from 1612 nm to 2335 nm and the incident angle ranges from 0° to 70°. The bandwidth of wide-angle absorption (0°-70°) reaches 723 nm. The designed absorber is a lithography-free 1D structure, which can be easily fabricated under the current magnetron sputtering or electron-beam vacuum deposition technique. This broadband, wide-angle, and lithography-free absorber would possess potential applications in the design of photodetectors, solar thermophotovoltaic devices, gas analyzers, and cloaking devices.

Terahertz high-Q quasi-bound states in the continuum in laser-fabricated metallic double-slit arrays.

A laser-fabricated metallic resonator based on a double-slit array (DSA) is numerically and experimentally demonstrated at terahertz frequencies. Such free-standing resonators achieve a sharp resonance with high quality (Q) factor, arising from a distortion of symmetry-protected bound states in the continuum (BIC). By breaking the structural symmetry of DSAs, the BIC with infinite Q-factor can be transformed into quasi-BICs, and the Q-factors decrease gradually as the asymmetry parameter increases. We analyzed the influence of the imperfection in experimental samples such as the round edge and the trapezoid shape on the transmission properties of DSAs. Different from the DSAs composed of ideal perfect electrical conductors, copper DSAs show lower Q-factor because of the Ohmic loss. The effect of metal thickness on the quasi-BICs for DSAs is also investigated. Results exhibit that thinner resonators can achieve sharper quasi-BICs. These findings suggest that such metallic resonators with high Q-factors have great potential for practical applications in electromagnetic wave filtering and biomolecular sensing.

Enhancing Goos-Hänchen shift based on magnetic dipole quasi-bound states in the continuum in all-dielectric metasurfaces.

Metasurface-mediated bound states in the continuum (BIC) provides a versatile platform for light manipulation at the subwavelength dimension with diverging radiative quality factor and extreme optical localization. In this work, we theoretically propose the magnetic dipole quasi-BIC resonance in asymmetric silicon nanobar metasurfaces to realize giant Goos-Hänchen (GH) shift enhancement by more than three orders of wavelength. In sharp contrast to GH shift based on the Brewster dip or transmission-type resonance, the maximum GH shift here is located at the reflection peak with unity reflectance, which can be conveniently detected in the experiment. By adjusting the asymmetric parameter of metasurfaces, the Q-factor and GH shift can be modulated accordingly. More interestingly, it is found that GH shift exhibits an inverse quadratic dependence on the asymmetric parameter. Furthermore, we theoretically design an ultrasensitive environmental refractive index sensor based on the quasi-BIC enhanced GH shift, with a maximum sensitivity of 1.5×107 µm/RIU. Our work not only reveals the essential role of BIC in engineering the basic optical phenomena but also suggests the way for pushing the performance limits of optical communication devices, information storage, wavelength division de/multiplexers, and ultrasensitive sensors.

Strong coupling between excitons and magnetic dipole quasi-bound states in the continuum in WS2-TiO2 hybrid metasurfaces.

Enhancing the light-matter interactions in two-dimensional materials via optical metasurfaces has attracted much attention due to its potential to enable breakthrough in advanced compact photonic and quantum information devices. Here, we theoretically investigate a strong coupling between excitons in monolayer WS2 and quasi-bound states in the continuum (quasi-BIC). In the hybrid structure composed of WS2 coupled with asymmetric titanium dioxide nanobars, a remarkable spectral splitting and typical anticrossing behavior of the Rabi splitting can be observed, and such strong coupling effect can be modulated by shaping the thickness and asymmetry parameter of the proposed metasurfaces, and the angle of incident light. It is found that the balance of line width of the quasi-BIC mode and local electric field enhancement should be considered since both of them affect the strong coupling, which is crucial to the design and optimization of metasurface devices. This work provides a promising way for controlling the light-matter interactions in strong coupling regime and opens the door for the future novel quantum, low-energy, distinctive nanodevices by advanced meta-optical engineering.