Detalhe da pesquisa
1.
Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.
Arch Toxicol;
2024 May 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38703205
2.
A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.
Arch Toxicol;
96(7): 2003-2019, 2022 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35357534
3.
Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis.
J Appl Toxicol;
40(11): 1534-1544, 2020 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32618019
4.
[Quantification of hepatotoxic pyrrolizidine alkaloid adonifoline in traditional Chinese medicine preparations containing Senecionis Scandentis Herba].
Zhongguo Zhong Yao Za Zhi;
45(1): 92-97, 2020 Jan.
Artigo
em Zh
| MEDLINE
| ID: mdl-32237416
5.
Gynura Rhizoma containing pyrrolizidine alkaloids induces the hepatic sinusoidal obstruction syndrome in mice via upregulating fibrosis-related factors.
Acta Pharmacol Sin;
40(6): 781-789, 2019 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30367152
6.
Evaluation of a Potential Clinical Significant Drug-Drug Interaction between Digoxin and Bupropion in Cynomolgus Monkeys.
Pharm Res;
36(1): 1, 2018 Nov 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30402714
7.
Preparation and purification of canthinone and ß-carboline alkaloids from Picrasma quassioides based on bioautography and mass-spectrometry-directed autopurification system.
J Sep Sci;
41(15): 3014-3021, 2018 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29797546
8.
[Systematical analysis of multiple components in drainage bear bile powder from different sources].
Zhongguo Zhong Yao Za Zhi;
43(11): 2326-2332, 2018 Jun.
Artigo
em Zh
| MEDLINE
| ID: mdl-29945386
9.
Negative feedback regulation between microRNA let-7g and LOX-1 mediated hypoxia-induced PASMCs proliferation.
Biochem Biophys Res Commun;
488(4): 655-663, 2017 07 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28108289
10.
Characterization of the Principal Constituents of Danning Tablets, a Chinese Formula Consisting of Seven Herbs, by an UPLC-DAD-MS/MS Approach.
Molecules;
21(5)2016 May 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27187345
11.
Quality Evaluation of Traditional Chinese Medicine Compounds in Xiaoyan Lidan Tablets: Fingerprint and Quantitative Analysis Using UPLC-MS.
Molecules;
21(2): 83, 2016 Jan 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26805803
12.
[Calpain mediated pulmonary vascular remodeling in hypoxia induced pulmonary hypertension].
Zhong Nan Da Xue Xue Bao Yi Xue Ban;
41(9): 929-36, 2016 Sep 28.
Artigo
em Zh
| MEDLINE
| ID: mdl-27640791
13.
Evaluation of hemostatic and anti-inflammatory activities of extracts from different Lagochilus species in experimental animals: comparison of different extractives and sources.
Phytother Res;
29(1): 22-9, 2015 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25175534
14.
Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid.
Chem Res Toxicol;
27(5): 775-86, 2014 May 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24641316
15.
Combination of UHPLC/Q-TOF-MS, NMR spectroscopy, and ECD calculation for screening and identification of reactive metabolites of gentiopicroside in humans.
Anal Bioanal Chem;
406(6): 1781-93, 2014 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24408300
16.
An application of target profiling analyses in the hepatotoxicity assessment of herbal medicines: comparative characteristic fingerprint and bile acid profiling of Senecio vulgaris L. and Senecio scandens Buch.-Ham.
Anal Bioanal Chem;
406(29): 7715-27, 2014 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25234307
17.
Mass-spectrometry-directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica.
J Sep Sci;
37(15): 2032-8, 2014 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24840731
18.
A chemically standardized extract of Ziziphus jujuba fruit (Jujube) stimulates expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes.
Phytother Res;
28(11): 1727-30, 2014 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25066116
19.
Mass spectrometric analysis strategies for pyrrolizidine alkaloids.
Food Chem;
445: 138748, 2024 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38422865
20.
Lusianthridin ameliorates high fat diet-induced metabolic dysfunction-associated fatty liver disease via activation of FXR signaling pathway.
Eur J Pharmacol;
965: 176196, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38006926