Detalhe da pesquisa
1.
Quantification of Phosphonate Drugs by 1H-31P HSQC Shows That Rats Are Better Models of Primate Drug Exposure than Mice.
Anal Chem;
94(28): 10045-10053, 2022 07 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35792073
2.
Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola.
Antimicrob Agents Chemother;
65(10): e0111721, 2021 09 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34252308
3.
Aliphatic amines are viable pro-drug moieties in phosphonoamidate drugs.
Bioorg Med Chem Lett;
30(24): 127656, 2020 12 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33130289
4.
The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues.
Molecules;
24(13)2019 Jul 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31324042
5.
Test of 5- Versus 10-Day Remdesivir Treatment in Immunocompromised Patients With Coronavirus Disease 2019.
Clin Infect Dis;
76(6): 1154-1155, 2023 03 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36346111
6.
Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver.
Antimicrob Agents Chemother;
65(10): e0133321, 2021 09 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34370586
7.
Remdesivir for COVID-19: Why Not Dose Higher?
Antimicrob Agents Chemother;
65(4)2021 03 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33558301
8.
Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity.
Antimicrob Agents Chemother;
64(12)2020 11 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32988821
9.
Correction: Cook et al. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses 2022, 14, 2429.
Viruses;
16(3)2024 Mar 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38543851
10.
Enolase inhibitors as therapeutic leads for Naegleria fowleri infection.
bioRxiv;
2024 Jan 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38293107
11.
Comparative Pharmacology of a Bis-Pivaloyloxymethyl Phosphonate Prodrug Inhibitor of Enolase after Oral and Parenteral Administration.
ACS Pharmacol Transl Sci;
6(2): 245-252, 2023 Feb 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36798479
12.
Enolase Inhibitors as Early Lead Therapeutics against Trypanosoma brucei.
Pathogens;
12(11)2023 Oct 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38003754
13.
Phosphoramidate Prodrugs Continue to Deliver: The Journey of Remdesivir (GS-5734) from the Liver to Peripheral Blood Mononuclear Cells.
ACS Med Chem Lett;
13(4): 520-523, 2022 Apr 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35450350
14.
An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats.
Viruses;
14(11)2022 11 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36366527
15.
Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers.
J Med Chem;
65(20): 13813-13832, 2022 10 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36251833
16.
Targeting Host Glycolysis as a Strategy for Antimalarial Development.
Front Cell Infect Microbiol;
11: 730413, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34604112
17.
Pharmacokinetics of Orally Administered GS-441524 in Dogs.
bioRxiv;
2021 May 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34100016
18.
Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine.
Nat Commun;
12(1): 4228, 2021 07 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34244484
19.
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Cell Metab;
33(12): 2380-2397.e9, 2021 12 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34879239
20.
Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.
ACS Med Chem Lett;
11(7): 1361-1366, 2020 Jul 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32665809