Effect of Different Types of Adhesive Agents on Orthodontic Bracket Shear Bond Strength: A Cyclic Loading Study.

Bracket failure is one of the most important problems encountered during fixed orthodontic treatment. For this reason, different types of adhesive agents have been developed over the years. Consequently, the aim of this study was to evaluate the shear bond strength of brackets bonded to teeth etched with a conventional acid etching method in a laboratory environment by using different types of adhesive agents and comparing the number of shear strokes. Sixty human maxillary premolars were divided into three groups and Gemini stainless steel metal brackets (3M Unitek, Monrovia, CA, USA) were bonded to all teeth. In Group 1, Transbond™ XT Primer (3M Unitek, Monrovia, CA, USA) and Transbond™ XT Light Cure Adhesive Paste composite (3M Unitek, Monrovia, CA, USA) were used. In Group 2, BracePaste® MTP Primer (American Orthodontics, Sheboygan, CA, USA) and BracePaste® Adhesive composite (American Orthodontics, Sheboygan, WI, USA) were used. In Group 3, Ortho Solo™ Primer (Ormco, Orange, CA, USA) and Grengloo™ Adhesive composite (Ormco, Brea, CA, USA) were used. The samples were subjected to a shear test with a closed-loop controlled, low-cycle fatigue machine with a capacity of 10 N and a crosshead speed of 300 mm/min. The number of shear strokes of the brackets was recorded. According to the Kruskal−Wallis and Mann−Whitney U tests performed on the data obtained, statistically significant differences were found between the groups in terms of the numbers of shear strokes (p < 0.05). Significantly higher numbers of shear strokes and higher shear bond strengths were observed in Group 3 compared with Group 1 and Group 2 (p < 0.05). There was no statistically significant difference between the numbers of shear strokes for Group 1 and Group 2 samples (p > 0.05). To conclude the study, it was observed that the type of adhesive used had an effect on the bond strength of the bracket and that the Grengloo™ adhesive agent showed higher shear bond strength. It was observed that BracePaste® Adhesive and Transbond™ XT Light Cure Adhesive Paste adhesive agents had similar shear bond strengths.

Mean Shearing Stroke Frequency of Orthodontic Brackets under Cycling Loading: An In Vitro Study.

Based on the development of many adhesive systems and bonding techniques, bonding strength of orthodontic brackets has become even more important in modern clinical orthodontics. The aim of this study was to determine mean shearing stroke frequency of different orthodontic bracket types and bonding agents under cycling loading. Therefore, 10 different types of orthodontic bracket from 4 different brands were divided into 2 groups. Two different adhesives, namely Transbond™ XT etch-and-rinse for Group 1 and Transbond™ Plus self-etching-primer adhesive for Group 2 were considered. The brackets were tested under cycling loading force of 10-N and a crosshead speed of 300 mm/min and 40 cycle/min. The frequency of strokes that the brackets failed were determined and these data were analyzed by statistical analysis using an independent sample t-test and one-way analysis of variance (ANOVA). The level of significance was set at p < 0.05. Generally, differences between the frequency of shearing strokes of the bracket failures were found to be statistically significant depending on the type of adhesives and brackets (p < 0.05). The bonding technique for Group 1 was found to have a significantly higher shear bonding strength than Group 2. It is also seen that different types of bracket belonging to the same or different brands had different shear bonding strength. It may be concluded that: (i) all bracket types used in this study can be applied with both bonding techniques, (ii) in order to minimize the risk of hard tissue damage, ceramic brackets should be carefully bonded using the self-etching primary adhesive technique.

Comparative Analysis of NF-κB in the MyD88-Mediated Pathway After Implantation of Titanium Alloy and Stainless Steel and the Role of Regulatory T Cells.

OBJECTIVE: Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants. METHODS: The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+. RESULTS: Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways. CONCLUSIONS: Results show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.

New Design for an Adjustable Cise Space Maintainer.

OBJECTIVE: The aim of this study is to present a new adjustable Cise space maintainer for preventive orthodontic applications. METHODS: Stainless steel based new design consists of six main components. In order to understand the major displacement and stress fields, structural analysis for the design is considered by using finite element method. RESULTS: Similar to major displacement at y-axis, critical stresses σx and τxy possess a linear distribution with constant increasing. Additionally, strain energy density (SED) plays an important role to determine critical biting load capacity. CONCLUSION: Structural analysis shows that the space maintainer is stable and is used for maintaining and/or regaining the space which arouses early loss of molar tooth.

[Comparison of the pull-out strengths of three different screws in pedicular screw revisions: a biomechanical study]. / Pediküler vida revizyonlarinda üç farkli tip vidanin siyirma kuvvetlerinin karsilastirilmasi: Biyomekanik çalisma.

OBJECTIVES: We investigated the possible effects of three pedicular screws on axial pull-out strength in pedicular revision surgery. METHODS: Two study groups were formed from calf lumbar vertebrae. Initially, Alici pedicular screws with an outer diameter of 6.5 mm were applied (with or without tapping) to all the pedicles. All the pedicles were subjected to axial pull-out testing to induce pedicular insufficiency. Then, Alici pedicular screws with an outer diameter of 7 mm were applied to the left pedicles. The right pedicles in the two study groups were assigned to receive two different types of pedicular screws with an expandable (enlargeable) end, respectively. Axial pull-out testing was repeated in both groups and the results were compared with the initial pull-out strength values. RESULTS: In the first group, 65% and 64% of the initial pull-out strengths were obtained with 7-mm Alici pedicular screws and with expandable pedicular screws, for the left and right pedicles, respectively. The corresponding pull-out strengths in the other study group were 70% and 68.5% of the initial values, respectively. Tapping of the screw hole entrance resulted in a mean decrease of 13% in the pull-out strength compared to screw applications without tapping. CONCLUSION: Pedicular screw revisions using a 0.5 mm greater screw in diameter did not provide adequate screw-bone inter-face strength and pedicle filling. Similarly, expandable pedicular screws did not contribute to screw stability.

A New Orthodontic Appliance with a Mini Screw for Upper Molar Distalization.

The aim of this study is to present a new upper molar distalization appliance called Cise distalizer designed as intraoral device supported with orthodontic mini screw for upper permanent molar distalization. The new appliance consists of eight main components. In order to understand the optimum force level, the appliance under static loading is tested by using strain gage measurement techniques. Results show that one of the open coils produces approximately 300 gr distalization force. Cise distalizer can provide totally 600 gr distalization force. This range of force level is enough for distalization of upper first and second molar teeth.

Molecular mechanism and targets of the antimicrobial activity of metal nanoparticles.

The emergence of multi-resistant bacteria to drugs is recognized as a major cause of the increasing number of deaths in hospitals. Killing these bacteria require multiple expensive drugs that can have side effects. Metal nanoparticles may provide a new strategy to combat them. Due the antimicrobial and antiviral properties, nanoparticles (NPs) have outstanding biological properties that can be handled properly for desired applications. This review presents antibacterial and antiviral activity of metal NPs, including the molecular mechanisms by which NPs annihilate multidrug-resistant bacteria.

Mesoporous materials used in medicine and environmental applications.

Mesoporous materials synthesized in the presence of templates, are commonly used for environment and medical applications. Due to the properties it holds, mesoporous silica nanoparticles is an excellent material for use in medical field, biomaterials, active principles delivery systems, enzyme immobilization and imaging. Their structure allows embedding large and small molecules, DNA adsorption and genetic transfer. Using mesoporous silica nanoparticles for delivery of bioactive molecules can protect them against degradation under physiological conditions, allow controlled drugs release and minimize side effects on healthy tissues. Cellular tests performed on mesoporous silica nanoparticles demonstrate that MSN's cytotoxicity is dependent on the size and concentration and suggests the use of larger size nanoparticles is optimal for medical applications. Mesoporous materials possess high biological compatibility, are non-toxic and can be easily modified by functionalizing the surface or inside the pores by grafting or co-condensation method. The structure, composition and pores size of this material can be optimized during synthesis by varying the stoichiometric reactants, reaction conditions, nature of the template's molecules or by functionalization method.

In vitro inhibition of caries-like lesions with fluoride-releasing materials.

The aim of this study was to compare the in vitro caries inhibition of various resin-based materials. Class V cavities were prepared in twenty-five freshly extracted human premolar teeth which were then restored with glass-ionomer cement (Chemfill II), compomer (Compoglass F, Dyract AP) and composite resin (Tetric Ceram and Z 100). The teeth were submerged in an acid gel for 6 weeks. Each specimen was sectioned. These sections were left in water for 24 hours, and then examined using polarized light microscopy. The lesion consisted of two parts, the outer surface lesion and the cavity wall lesion. There was no significant difference in the body depth of the outer lesion and in the depth of the wall lesion among teeth restored with Compoglass F, Dyract AP and Chemfill II (P > 0.05). There was a significant difference between those restored with Z 100 and Tetric Ceram (P < 0.05). The length of the wall lesion for the teeth restored with Chemfill II was significantly smaller than that in the remaining groups (P < 0.05). The length of the wall lesion for teeth restored with Tetric Ceram and Z 100 was significantly higher than in the remaining groups (P < 0.05). These results suggest that composite materials and compomer provide less caries inhibition than glass-ionomer cements.

Nanostructured biomaterials with antimicrobial properties.

The present review is intended to bring together the main advances in the field of nanostructured biomaterials with antimicrobial properties. It is generally accepted that the discovery of antibiotics was of great importance but, nowadays new antimicrobial agents are needed and/or their better administration routes. The limitation of the use of antibiotics is essential because of the following reasons: the excessive use of antibiotics leads to the development of antibiotic resistant microorganisms; there are some alternatives for many types of infections, many of these alternatives being less toxic and do not lead to antibiotic similar resistance. In compliance with the above presented, the use of antibiotic is recommended to be eliminated (when alternatives are available) or to be reduced by using combined therapy when possible or to administrate these drugs through targeted or loco-regional drug delivery systems.