Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
1.
Zhongguo Zhong Yao Za Zhi ; 38(23): 4076-8, 2013 Dec.
Artigo em Zh | MEDLINE | ID: mdl-24791492

RESUMO

OBJECTIVE: To optimize formulas of Quban gel. METHOD: The U6 (6(2) x 3) uniform design was adopted to optimize gel formulas, with rheological parameters, such as viscosity and yield value in room temperature, viscosity and yield value in average temperature of skin, thixlotropy. RESULT: The optimum proportion of matrix was made of 1.0 g carbomer 940, 5 mL glycerin and pH value 5-6. CONCLUSION: The regression model for gel matrix quality and gel rheological parameters was established to directly reflect the impacting effect of various factors, and provide certain preference basis for the screening of gel matrix formulas. Quban gel prepared by the method was evenly distributed, moderately viscous and highly thixotropic


Assuntos
Química Farmacêutica/métodos , Medicamentos de Ervas Chinesas/química , Géis , Controle de Qualidade , Análise de Regressão , Viscosidade
2.
Sci Total Environ ; 702: 134705, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31726341

RESUMO

Electricity generation may create high levels of pollution, but its consumption is completely clean. Long-distance electricity transfers make the allocation of environmental externalities caused by electricity generation unfair at the regional level. This paper provides a generalized approach that can be used to evaluate air pollution and health loss embodied in electricity transfers. Impact pathway approach is combined with a network approach to evaluate embodied direct health loss and a sophisticated evaluation of air pollution diffusion is implemented to assess indirect environmental impacts between regions. Using China's inter-provincial power transmission as an example, this paper also reveals various air pollutant and health loss transfer patterns among the nation's provinces. The results emphasize the importance of characterizing the embodied environmental effects in electricity transfer through health losses rather than air pollution emissions. The inter-regional indirect impacts due to the diffusion of pollutants must be considered when examining the embodied health losses, which is even higher than the direct impact on the local. Several central regions in China, adjacent to the major electricity-export provinces, do not export a large amount of electricity, yet their health losses have increased significantly due to nationwide power transfers. The direct external health costs of electricity generation in China's major power-exporting provinces are relatively low. However, when indirect impacts are considered, external costs in the central and northern regions increase significantly. Therefore, the regional environmental benefits of shifting electricity generation to resource-rich remote areas are greatly reduced for many pairs of provinces.

3.
Chin J Integr Med ; 25(7): 497-501, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31278627

RESUMO

OBJECTIVE: To investigate the relation of blood arsenic concentration (BAC) with clinical effect and safety of arsenic-containing Qinghuang Powder (, QHP) in patients with myelodysplastic syndrome (MDS). METHODS: Totally 163 patients with MDS were orally treated with QHP for 2 courses of treatment, 3 months as 1 course. The BACs of patients were detected by atomic fluorescence spectrophotometry at 1, 3, and 6 months during the treatment, and the effective rate, hematological improvement and safety in patients after treatment with QHP were analyzed. RESULTS: After 2 courses of treatment, the total effective rate was 89.6% (146/163), with 31.3% (51/163) of hematological improvement and 58.3% (95/163) of stable disease. The hemoglobin increased from 73.48 ± 19.30 g/L to 80.39 ± 26.56 g/L (P<0.05), the absolute neutrophil count increased from 0.81 ± 0.48 × 109/L to 1.08 ± 0.62 × 109/L (P<0.05), and no significant changes were observed in platelet counts (P>0.05). Among 46 patients previously depended on blood transfusion, 28.3% (13/46) completely got rid of blood transfusion and 21.7% (10/46) reduced the volume of blood transfusion by more than 50% after treatment. The BACs were significantly increased in patients treated for 1 month with 32.17 ± 18.04 µ g/L (P<0.05), 3 months with 33.56 ± 15.28 µ g/L (P<0.05), and 6 months with 36.78 ± 11.92 µ g/L (P<0.05), respectively, as compared with those before treatment (4.08 ± 2.11 µ g/L). There were no significant differences of BACs among the patients treated for 1, 3 and 6 months (P>0.05). The adverse reactions of digestive tract during the treatment were mild abdominal pain and diarrhea in 14 cases (8.6%), and no patients discontinued the treatment. The BACs of patients with gastrointestinal adverse reactions were significantly lower than those without gastrointestinal adverse reactions (22.39 ± 10.38 vs. 37.89 ± 11.84, µ g/L, P<0.05). The BACs of patients with clinical effect were significantly higher than those failed to treatment (40.41 ± 11.69 vs. 23.84 ± 12.03, µ g/L, P<0.05). CONCLUSION: QHP was effective and safe in the treatment of patients with MDS and the effect was associated with BACs of patients.


Assuntos
Arsênio/sangue , Arsenicais/efeitos adversos , Arsenicais/uso terapêutico , Medicamentos de Ervas Chinesas/efeitos adversos , Medicamentos de Ervas Chinesas/uso terapêutico , Síndromes Mielodisplásicas/sangue , Síndromes Mielodisplásicas/tratamento farmacológico , Contagem de Células Sanguíneas , Transfusão de Sangue , Humanos , Cariótipo , Pós , Fatores de Risco
4.
Chin J Integr Med ; 24(7): 494-501, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27286711

RESUMO

OBJECTIVE: To investigate the pro-angiogenic effects of paeoniflorin (PF) in a vascular insufficiency model of zebrafish and in human umbilical vein endothelial cells (HUVECs). METHODS: In vivo, the pro-angiogenic effects of PF were tested in a vascular insufficiency model in the Tg(fli-1:EGFP)y1 transgenic zebrafish. The 24 h post fertilization (hpf) embryos were pretreated with vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor II (VRI) for 3 h to establish the vascular insufficiency model and then post-treated with PF for 24 h. The formation of intersegmental vessels (ISVs) was observed with a fluorescence microscope. The mRNA expression of fms-like tyrosine kinase-1 (flt-1), kinase insert domain receptor (kdr), kinase insert domain receptor like (kdrl) and von Willebrand factor (vWF) were analyzed by real-time polymerase chain reaction (PCR). In vitro, the pro-angiogenic effects of PF were observed in HUVECs in which cell proliferation, migration and tube formation were assessed. RESULTS: PF (6.25-100 µmol/L) could rescue VRI-induced blood vessel loss in zebrafish and PF (25-100 µmol/L), thereby restoring the mRNA expressions of flt-1, kdr, kdrl and vWF, which were down-regulated by VRI treatment. In addition, PF (0.001-0.03 µmol/L) could promote the proliferation of HUVECs while PF stimulated HUVECs migration at 1.0-10 µmol/L and tube formation at 0.3 µmol/L. CONCLUSION: PF could promote angiogenesis in a vascular insufficiency model of zebrafish in vivo and in HUVECs in vitro.


Assuntos
Indutores da Angiogênese/uso terapêutico , Glucosídeos/uso terapêutico , Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos , Monoterpenos/uso terapêutico , Neovascularização Fisiológica/efeitos dos fármacos , Doenças Vasculares/tratamento farmacológico , Doenças Vasculares/patologia , Indutores da Angiogênese/farmacologia , Animais , Animais Geneticamente Modificados , Células Cultivadas , Modelos Animais de Doenças , Medicamentos de Ervas Chinesas/farmacologia , Medicamentos de Ervas Chinesas/uso terapêutico , Embrião não Mamífero , Glucosídeos/farmacologia , Células Endoteliais da Veia Umbilical Humana/fisiologia , Humanos , Monoterpenos/farmacologia , Fitoterapia , Peixe-Zebra
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA