Actuation-enhanced multifunctional sensing and information recognition by magnetic artificial cilia arrays.

Artificial cilia integrating both actuation and sensing functions allow simultaneously sensing environmental properties and manipulating fluids in situ, which are promising for environment monitoring and fluidic applications. However, existing artificial cilia have limited ability to sense environmental cues in fluid flows that have versatile information encoded. This limits their potential to work in complex and dynamic fluid-filled environments. Here, we propose a generic actuation-enhanced sensing mechanism to sense complex environmental cues through the active interaction between artificial cilia and the surrounding fluidic environments. The proposed mechanism is based on fluid-cilia interaction by integrating soft robotic artificial cilia with flexible sensors. With a machine learning-based approach, complex environmental cues such as liquid viscosity, environment boundaries, and distributed fluid flows of a wide range of velocities can be sensed, which is beyond the capability of existing artificial cilia. As a proof of concept, we implement this mechanism on magnetically actuated cilia with integrated laser-induced graphene-based sensors and demonstrate sensing fluid apparent viscosity, environment boundaries, and fluid flow speed with a reconfigurable sensitivity and range. The same principle could be potentially applied to other soft robotic systems integrating other actuation and sensing modalities for diverse environmental and fluidic applications.

Unveiling human origins of replication using deep learning: accurate prediction and comprehensive analysis.

Accurate identification of replication origins (ORIs) is crucial for a comprehensive investigation into the progression of human cell growth and cancer therapy. Here, we proposed a computational approach Ori-FinderH, which can efficiently and precisely predict the human ORIs of various lengths by combining the Z-curve method with deep learning approach. Compared with existing methods, Ori-FinderH exhibits superior performance, achieving an area under the receiver operating characteristic curve (AUC) of 0.9616 for K562 cell line in 10-fold cross-validation. In addition, we also established a cross-cell-line predictive model, which yielded a further improved AUC of 0.9706. The model was subsequently employed as a fitness function to support genetic algorithm for generating artificial ORIs. Sequence analysis through iORI-Euk revealed that a vast majority of the created sequences, specifically 98% or more, incorporate at least one ORI for three cell lines (Hela, MCF7 and K562). This innovative approach could provide more efficient, accurate and comprehensive information for experimental investigation, thereby further advancing the development of this field.

Ultracompact and Uniform Nanoemitter Array Based on Periodic Scattering.

As emerging gain materials, lead halide perovskites have drawn considerable attention in coherent light sources. With the development of patterning and integration techniques, a perovskite laser array has been realized by distributing perovskite microcrystals periodically. Nevertheless, the packing density is limited by the crystal size and the channel gap distance. More importantly, the lasing performance for individual laser units is quite random due to variation of size and crystal quality. Herein an ultracompact perovskite nanoemitter array with uniform emission has been demonstrated. Individual emitters are formed via scattering evanescent components from a shared Fabry-Perot laser, ensuring uniform lasing emission in a unit cell with a side length of 160 nm and lattice constant of 400 nm. And the periodic silicon scatterers do not deteriorate the lasing threshold dramatically. In addition, the surface emitting efficiency increased significantly. The direct integration of a densely packed nanoemitter array with a silicon platform promises high-throughput sensing and high-capacity optical interconnects.

Theoretical analysis for estimating laser integrated linewidth via frequency-noise power spectral density.

The measurement of a laser linewidth is significant in metrology, coherent optical communications, high-resolution sensing, and LIDAR. Firstly, in this study, we theoretically explain why estimating an integrated linewidth via a frequency-noise power spectral density (PSD) is valid. We find that the previous methods estimating the integrated linewidth via the frequency-noise PSD result from Gaussian approximation and obtain a more general consequence. Secondly, according to the theory, we propose the Voigt approximation method to improve the estimation performance. The simulation results show the Voigt approximation estimation error is lower than 5%. Finally, based on the Voigt approximation, the relationship between the interference visibility and laser linewidth is found, providing a possible convenient approach to measuring the linewidth.

Dietary Selenium Insufficiency Induces Cardiac Inflammatory Injury in Chicks.

BACKGROUND: Laying hens undergo intensive metabolism and are vulnerable to cardiac insults. Previous research demonstrated overt heart disorders of broiler chickens induced by dietary Se deficiency. OBJECTIVES: This study aimed to reveal effects and mechanism of dietary Se insufficiency on cardiac injuries of egg-type chicks in their early life. METHODS: White Leghorn chicks (0-d-old, female) were fed a corn-soy, Se-insufficient basal diet (BD, 0.05 mg Se/kg; n = 11) or the BD supplemented with 0.3 mg Se/kg (as sodium selenite; n = 8) for 35 d. Cardiac tissues were collected at the end of study for histology and to determine its relationship with heart Se contents, selenoprotein expression profiles, antioxidant and inflammatory status, and the Toll-like receptor 4/extracellular signal-regulated kinases/p38 map kinase/c-Jun N-terminal kinase (TLR4/ERK/P38/JNK) pathway. RESULTS: Compared with those fed 0.35 mg Se/kg, chicks fed BD had significantly lower body weights and average daily gain, and 28% lower heart Se, and developed cardiac mononuclear inflammatory cell infiltration, along with elevated (P < 0.05) serum concentrations of creatine kinase, aldolase, and interleukin-1 (IL-1). The BD decreased (P < 0.05) body weight and heart glutathione contents and expression of selenoproteins but increased (P < 0.05) heart concentrations of malondialdehyde and reactive oxygen species. These changes were associated with increased (P < 0.05) mRNA and/or protein concentrations of cyclooxygenases, lipoxygenase-12, cytokines (IL-1ß), nuclear factor (NF) κB subunit, chemokines, and receptors (CCL20, CXCR1, and CXCLI2) and increased (P < 0.1) TLR4/ERK /P38/JNK in the heart of Se-insufficient chicks. CONCLUSIONS: Dietary Se insufficiency induces infiltration of mononuclear inflammatory cells in the heart of egg-type chicks. This cardiac injury was mediated by decreased functional expressions of selenoproteins, which resulted in apparent elevated oxidative stress and subsequent activations of the TLR4 pathway and NF κB.

Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.

Strategies targeting lin-28 homolog A (LIN28A) for the treatment of osteosarcoma are limited, even though salient findings have illustrated the crucial role of LIN28A in bone deformities and cancer. In the present study, we proved circ_0096041, one of the circular RNAs (circRNAs) with significant upregulated expression in osteosarcoma, to be notably engaged in the progression of osteosarcoma. We elucidated that osteosarcoma patients with highly expressed circ_0096041 had relatively worse prognoses. We determined that circ_0096041 potentially sponge miR-556-5p using the Circular RNA Interactome database. Meanwhile, we proved circ_0096041 was associated with miR-556-5p. Furthermore, we determined that miR-556-5p was targeted by LIN28A directly, evidenced by in silico analysis using the miRWALK tool and in vitro analysis. Functionally, our experimental setting aimed to explore the function of circ_0096041/miR-556-5p/LIN28A axis in vitro and in vivo. Our findings demonstrated that circ_0096041 boosted the proliferation and migration of osteosarcoma via LIN28A/miR-556-5p axis. In vivo models were further established to estimate the metastasis promoted by circ_0096041. This research elucidated the enhanced osteosarcoma progression by circ_0096041 and its potential mechanism, which provided innovative targets for osteosarcoma treatment.

Arthroscopic dual-bone tunnel repair for palmer type IB injuries of the triangular fibrocartilage complex.

BACKGROUND: Triangular fibrocartilage complex (TFCC) injuries, especially Palmer type IB, pose surgical management challenges due to associated distal radial ulnar joint (DRUJ) instability. Traditional surgeries entail risks of complications. Arthroscopic repair presents advantages but lacks consensus on optimal techniques. To evaluate arthroscopic dual-bone tunnel repair in patients with Palmer type IB TFCC injuries of the wrist. METHODS: In this retrospective case series, grip strength ratio, joint range of motion, pain visual analogue scale (VAS), modified Mayo wrist score, and Disabilities of the Arm, Shoulder, and Hand (DASH) scores were assessed before and 12 months after surgery. RESULTS: The cohort consisted of 45 patients. At 12 months, the grip strength ratio improved from 0.71 ± 0.08 to 0.93 ± 0.05 (P < 0.001), and wrist joint rotation increased from 126.78 ± 13.28° to 145.76 ± 8.52° (P < 0.001). VAS (1.60 ± 0.58 vs. 6.33 ± 0.91, P < 0.001), DASH (12.96 ± 3.18 vs. 46.87 ± 6.62, P < 0.001), and modified Mayo wrist (88.11 ± 4.43 vs. 63.78 ± 7.99, P < 0.001) scores all improved after surgery. The overall complication rate was 4.44%. CONCLUSION: Arthroscopic dual-bone tunnel repair appears to be an effective intervention for alleviating wrist pain, restoring stability, and enhancing joint function in patients with TFCC Palmer type IB injuries.

V2 Protein Enhances the Replication of Genomic DNA of Mulberry Crinkle Leaf Virus.

Mulberry crinkle leaf virus (MCLV), identified in mulberry plants (Morus alba L.), is a member of the genus Mulcrilevirus in the family Geminiviridae. The functions of the V2 protein encoded by MCLV remain unclear. Here, Agrobacterium-mediated infectious clones of a wild-type MCLV vII (MCLVWT) and two V2 mutant MCLV vIIs, including MCLVmV2 (with a mutation of the start codon of the V2 ORF) and MCLVdV2 (5'-end partial deletion of the V2 ORF sequence), were constructed to investigate the roles of V2 both in planta and at the cellular level. Although all three constructs (pCA-1.1MCLVWT, pCA-MCLVmV2, and pCA-MCLVdV2) were able to infect both natural host mulberry plants and experimental tomato plants systematically, the replication of the MCLVmV2 and MCLVdV2 genomes in these hosts was significantly reduced compared to that of MCLVWT. Similarly, the accumulation of MCLVmV2 and MCLVdV2 in protoplasts of Nicotiana benthamiana plants was significantly lower than that of MCLVWT either 24 h or 48 h post-transfection. A complementation experiment further confirmed that the decreased accumulation of MCLV in the protoplasts was due to the absence of V2 expression. These results revealed that MCLV-encoded V2 greatly enhances the level of MCLV DNA accumulation and is designated the replication enhancer protein of MCLV.

A Green and Efficient Electrocatalytic Route for the Highly-Selective Oxidation of C-H Bonds in Aromatics over 1D Co3O4-Based Nanoarrays.

Electrocatalytic oxidation of C-H bonds in hydrocarbons represents an efficient and sustainable strategy for the synthesis of value-added chemicals. Herein, a highly selective and continuous-flow electrochemical oxidation process of toluene to various oxygenated products (benzyl alcohol, benzaldehyde, and benzyl acetate) is developed with the electrocatalytic membrane electrodes (ECMEs). The selectivity of target products can be manipulated via surface and interface engineering of Co3O4-based electrocatalysts. We achieved a high benzaldehyde selectivity of 90% at a toluene conversion of 47.6% using 1D-Co3O4 nanoneedles (NNs) loaded on a microfiltration (MF) titanium (Ti) membrane, i.e, Co3O4 NNs/Ti. In contrast, the main product shifted to benzyl alcohol with a selectivity of 90.1% at conversion of 32.1% after modifying MnO2 nanosheets (NSs) on Co3O4 NNs/Ti (Co3O4@MnO2/Ti) catalyst. Moreover, benzyl acetate product can be obtained with selectivity of 92% at a conversion of 58.5% at high current density (> 1.5mA cm-2), demonstrating that the pathway of toluene oxidation is readily maneuvered. DFT results reveal that modifying MnO2 on Co3O4 optimizes the electron structure of Co3O4@MnO2/Ti and modulates the adsorption behavior of intermediate species. This work demonstrates a sustainable, and continuous-flow process for precise control over production selectivity of value-added oxygenated derivatives in electrochemical oxidation of aromatic hydrocarbons.

Practical semi-quantum key distribution with one-way key and one basis.

Semi-quantum key distribution (SQKD) protocols are used to distribute secret keys between a quantum party and a classical party. However, existing SQKD protocols rely on two-way communication, and may still be vulnerable to Trojan horse side-channel attacks where Eve sends her own photon into a receiver's apparatus and measures the reflected photon to estimate the key. In this paper, we propose a practical SQKD with one-way key. This requires that the single photons travelling through the one-way channel are used to encode bit information, and the returned photons are used to quantify Eve's information, thus reducing the security analysis of the Trojan horse attack in SQKD. Meanwhile, our protocol with one basis enjoys security advantage in practical SQKD systems when source flaws are taken into account. In particular, the present protocol is secure under practical conditions when weak coherent pulses (WCP) are used. Our simulation results show that the protocol using WCP can distribute secret keys over a distance of 110 km without decoy states.

Fabrication and application of free-standing fiber based on blue phase liquid crystal.

The application of blue phase liquid crystals (BPLCs) in optical control devices has been widely studied due to their fast response characteristics. However, the fabrication of free-standing BPLC fiber with emerging functionalities is challenging. Here, we demonstrate a free-standing fiber based on BPLC with excellent stability, flexibility, and multifunction. The multi-mode fiber (MMF) end face is etched by the etching agent of buffered oxide etch (BOE), which can be fixedly connected with the free-standing BPLC fiber after polymerization in order to overcome the problems of optical signals transmission and reception. Three types of free-standing BPLC fiber-based devices, including Volatile Organic Compound (VOC) vapor sensors, vector position sensors, and color fibers, are fabricated and investigated, to the best of our knowledge, for the first time. The free-standing BPLC fiber as a multifunctional material will provide broad application prospects in VOC sensors without power supply, smart fabrics, flexible displays, decorations fields with no dyes, as well as vector displacement sensors for robotic arm positioning.

Afterpulse effects in quantum key distribution without monitoring signal disturbance.

The round-robin differential phase shift (RRDPS) quantum key distribution (QKD) protocol is the only one that does not require monitoring of signal disturbance. Moreover, it has been proven that RRDPS has excellent performance of resistance to finite-key effects and high error rate tolerance. However, the existing theories and experiments do not take the afterpulse effects into account, which cannot be neglected in high-speed QKD systems. Here, we propose a tight finite-key analysis with afterpulse effects. The results show that the non-Markovian afterpulse RRDPS model optimizes the system performance considering afterpulse effects. The advantage of RRDPS over decoy-state BB84 under short-time communication still holds at typical values of afterpulse.

Experimental Demonstration of Fully Passive Quantum Key Distribution.

The passive approach to quantum key distribution (QKD) consists of removing all active modulation from the users' devices, a highly desirable countermeasure to get rid of modulator side channels. Nevertheless, active modulation has not been completely removed in QKD systems so far, due to both theoretical and practical limitations. In this Letter, we present a fully passive time-bin encoding QKD system and report on the successful implementation of a modulator-free QKD link. According to the latest theoretical analysis, our prototype is capable of delivering competitive secret key rates in the finite key regime.

General temporal ghost imaging model with detection resolution and noise.

Improving imaging quality while reducing the sampling time simultaneously is a crucial challenge that limits the practical application of temporal ghost imaging (TGI). To improve the performance of TGI, various methods have been proposed and verified. However, a work analyzing in detail the influence of intensity accuracy and detection noise of TGI is still absent. Here, we establish an evaluation model to quantify the imaging quality of TGI and differential TGI (DTGI). Our model considers the intensity detection accuracy, threshold, and noise of the test path during image reconstruction and quantifies their influences by developing general imaging formulas of (D)TGI. We also simulate the imaging of (D)TGI numerically. The evaluation demonstrates that (D)TGI is relatively not sensitive to detection accuracy and thresholds of the test path, and image quality is degraded slightly even when those parameters turn much worse. (D)TGI is relatively robust to detection noise but will be unable to reconstruct the object when noise is too strong. DTGI does not show clear advantages over TGI. Our work develops an effective model to quantify the image quality with practical parameters and is significant to real applications of (D)TGI.

Association of follicle-stimulating hormone with bone turnover markers and bone mineral density in Chinese women across the menopausal transition.

BACKGROUND: Elevated follicle-stimulating hormone (FSH) is associated with an increased risk of postmenopausal osteoporosis. This study investigated the association of serum FSH with bone turnover markers (BTMs) and bone mineral density (BMD) in healthy women undergoing menopausal transition. METHODS: A total of 487 healthy women (age 35-65 years, 50 ± 8.5 years) were enrolled in this study. Serum FSH, BTMs, and BMD at lumbar spine and total hip were measured in these subjects. RESULTS: Follicle-stimulating hormone was positively correlated with various BTMs (r = 0.339-0.583, all p < 0.001) and negatively correlated with lumbar spine and total hip BMD (r = -0.629 and -0.514, all p < 0.001). After adjusting for age and body mass index, the partial correlation coefficients of FSH with BTMs and BMD remained significant. Estimating from the regression equation, for every 10 IU/L increase in serum FSH, BTMs increased by 0.38-3.6 units, and BMD decreased by 0.03-0.05 g/cm2 , respectively. Multiple linear regression analysis showed that FSH was a positive factor for serum bone-specific alkaline phosphatase, osteocalcin, and N-telopeptide of collagen type 1 (ß = 0.188-0.403, all p < 0.001), and a negative factor for lumbar spine BMD and serum C-telopeptide of collagen type 1 (ß = -0.629 and -0.183, all p < 0.001). CONCLUSIONS: This study suggests that serum FSH levels are an independent risk factor for BTMs and BMD in menopause-transitioning women, particularly for serum BAP and lumbar spine BMD.

Finite-Key Analysis for Quantum Key Distribution with Discrete-Phase Randomization.

Quantum key distribution (QKD) allows two remote parties to share information-theoretic secret keys. Many QKD protocols assume the phase of encoding state can be continuous randomized from 0 to 2π, which, however, may be questionable in the experiment. This is particularly the case in the recently proposed twin-field (TF) QKD, which has received a lot of attention since it can increase the key rate significantly and even beat some theoretical rate-loss limits. As an intuitive solution, one may introduce discrete-phase randomization instead of continuous randomization. However, a security proof for a QKD protocol with discrete-phase randomization in the finite-key region is still missing. Here, we develop a technique based on conjugate measurement and quantum state distinguishment to analyze the security in this case. Our results show that TF-QKD with a reasonable number of discrete random phases, e.g., 8 phases from {0,π/4,π/2,…,7π/4}, can achieve satisfactory performance. On the other hand, we find the finite-size effects become more notable than before, which implies that more pulses should be emit in this case. More importantly, as a the first proof for TF-QKD with discrete-phase randomization in the finite-key region, our method is also applicable in other QKD protocols.

Pre-compressed polymer cholesteric liquid crystal based optical fiber VOC sensor with high stability and a wide detection range.

As the concentration of VOC gases is very high in organic chemical reactions, in order to ensure the safety and accuracy of the experiment, it is very important to develop a gas sensor with a wide detection range. Exploring the mechanism and law of photonic bandgap (PBG) shift after absorption of volatile organic compounds (VOCs) vapors are two basic premises of resolving the PCLC for gas detection with a wide measurement range and stability. Herein, the PCLC films doped with different concentrations of polymer are used for acetone vapor detection, and the shift law of the PBG position is analyzed. As the increase of the detected gas concentration, the intractable problem is that the PBG position of PCLC exhibits red- and blue-shifts successively. Particularly, the pre-compressed technique is highly important for development of a high-performance PCLC based fiber probe, which is crucial for effectively solving the bottleneck problem mentioned. It enables detection of a wide range of acetone vapor concentration from 0 ppm to 50×104 ppm, and the corresponding mean sensitivity of 0.23 pm/ppm. In addition, the thermal crosstalk is generally negligible at temperature below 40°C. Therefore, it is a breakthrough that the described technique not only effectively enhances the stability and robustness of the PCLC fiber probe for VOC vapor detection, but also improves its sensitivity and detection range. The pre-compressed technique provides a novel avenue for fabrication of other PCLC-based devices.

Imperfection-insensitivity quantum random number generator with untrusted daily illumination.

Quantum random number generators (QRNGs) promise secure randomness generation based on the foundational unpredictability of quantum mechanics. However, the unavoidable gaps between theoretical models and practical devices could lead to security invalidation. Recently, a source-independent quantum random number generator (SI-QRNG) has been proposed to solve the issue of uncharacteristic sources. However, in most current analyses of SI-QRNG protocols, the security proofs with imperfect measurements are individual for different factors and very sensitive to small deviations from theoretical models. Here, we establish a unified model for imperfect measurements in the SI-QRNG and provide a tight rate bound based on the uncertainty relation for smooth entropies. Then the performance with large device imperfections is evaluated and the randomness rate in our model can approach a similar order of magnitude of the rate upper bound in common discrete variable QRNGs. In addition, by utilizing the daily illumination and measurement devices with large imperfections, we experimentally demonstrate our scheme at the rate of the order of magnitude of Mbps.

Electrically switchable structural colors based on liquid-crystal-overlaid aluminum anisotropic nanoaperture arrays.

Actively tunable or reconfigurable structural colors are highly promising in future development for high resolution imaging and displaying applications. To this end, we demonstrate switchable structural colors covering the entire visible range by integrating aluminum nanoaperture arrays with nematic liquid crystals. The geometrically anisotropic design of the nanoapertures provides strong polarization-dependent coloration. By overlaying a nematic liquid crystal layer, we further demonstrate switchable ability of the structural colors by either changing the polarization of the incident light or applying an external voltage. The switchable structural colors have a fast response time of 28 ms at a driving voltage of 6.5 V. Furthermore, colorful patterns are demonstrated by coding the colors with various dimensions of nanoaperture arrays with dual switching modes. Our proposed technique in this work provides a dual-mode switchable structural colors, which is highly promising for polarimetric displays, imaging sensors, and visual cryptography.

Transmittance-invariant phase modulator for chip-based quantum key distribution.

In chip-based quantum key distribution (QKD) systems, the non-ideal quantum state preparation due to the imperfect electro-optic phase modulators (EOPM) decreases the secret key rate and introduces potential vulnerabilities. We propose and implement an on-chip transmittance-invariant phase modulator (TIPM) to solve this problem. Simulated and experimental results show that TIPM can eliminate the correlation between phase, intensity, and polarization of quantum states caused by phase-dependent loss. The design can tolerate a significant fabrication mismatch and is universal to multi-material platforms. Furthermore, TIPM increases the modulation depth achievable by EOPMs in standard process design kit (PDK). The proposal of TIPM can improve the practical security and performance of the chip-based QKD systems.