Detalhe da pesquisa
1.
Generation of rat forebrain tissues in mice.
Cell;
187(9): 2129-2142.e17, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38670071
2.
A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects.
Nat Methods;
17(6): 600-604, 2020 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32424272
3.
Prediction and Validation of Mouse Meiosis-Essential Genes Based on Spermatogenesis Proteome Dynamics.
Mol Cell Proteomics;
20: 100014, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33257503
4.
Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing.
Development;
145(20)2018 10 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30275281
5.
Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy.
J Clin Invest;
133(3)2023 02 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36512423
6.
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects.
Nat Biotechnol;
41(1): 108-119, 2023 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35953673
7.
Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods.
Nat Commun;
12(1): 4902, 2021 08 12.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34385461
8.
Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains.
Stem Cells;
27(2): 383-9, 2009 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19056907
9.
GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos.
Nat Protoc;
15(9): 3009-3029, 2020 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32796939
10.
Disruption of splicing-regulatory elements using CRISPR/Cas9 to rescue spinal muscular atrophy in human iPSCs and mice.
Natl Sci Rev;
7(1): 92-101, 2020 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34691481
11.
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.
Science;
364(6437): 289-292, 2019 04 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30819928
12.
Base-Editing-Mediated R17H Substitution in Histone H3 Reveals Methylation-Dependent Regulation of Yap Signaling and Early Mouse Embryo Development.
Cell Rep;
26(2): 302-312.e4, 2019 01 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30625312
13.
Human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors.
Genome Biol;
20(1): 101, 2019 05 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31118069
14.
Tild-CRISPR Allows for Efficient and Precise Gene Knockin in Mouse and Human Cells.
Dev Cell;
45(4): 526-536.e5, 2018 05 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29787711
15.
In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice.
Nat Neurosci;
21(3): 440-446, 2018 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29335603
16.
CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms.
EBioMedicine;
20: 19-26, 2017 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28527830
17.
CRISPR/Cas9-mediated targeted chromosome elimination.
Genome Biol;
18(1): 224, 2017 11 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29178945
18.
Homology-mediated end joining-based targeted integration using CRISPR/Cas9.
Cell Res;
27(6): 801-814, 2017 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28524166
19.
One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.
Cell Res;
27(7): 933-945, 2017 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28585534
20.
Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos.
Protein Cell;
12(9): 741-745, 2021 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33797032