Detalhe da pesquisa
1.
Randomized, Double-Blinded, Placebo-Controlled Phase 2 Trial of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in Healthy Adults.
Clin Infect Dis;
73(11): e3949-e3955, 2021 12 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33165503
2.
A Phase I, Randomized, Double-Blinded, Placebo- and Moxifloxacin-Controlled, Four-Period Crossover Study To Evaluate the Effect of Gepotidacin on Cardiac Conduction as Assessed by 12-Lead Electrocardiogram in Healthy Volunteers.
Antimicrob Agents Chemother;
61(5)2017 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28223381
3.
Solithromycin, a novel macrolide, does not prolong cardiac repolarization: a randomized, three-way crossover study in healthy subjects.
J Antimicrob Chemother;
72(2): 515-521, 2017 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27798210
4.
Safety, pharmacokinetics, pharmacogenomics and QT concentration-effect modelling of the SirT1 inhibitor selisistat in healthy volunteers.
Br J Clin Pharmacol;
79(3): 477-91, 2015 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25223836
5.
Detection of QTc effects in small studies--implications for replacing the thorough QT study.
Ann Noninvasive Electrocardiol;
20(4): 368-77, 2015 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25367715
6.
Use of ECG restitution (beat-to-beat QT-TQ interval analysis) to assess arrhythmogenic risk of QTc prolongation with guanfacine.
Ann Noninvasive Electrocardiol;
19(6): 582-94, 2014 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25200912
7.
Use of continuous ECG for improvements in assessing the standing response as a positive control for QT prolongation.
Ann Noninvasive Electrocardiol;
19(1): 82-9, 2014 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24460808
8.
Lomitapide at supratherapeutic plasma levels does not prolong the Qtc interval--results from a TQT study with moxifloxacin and ketoconazole.
Ann Noninvasive Electrocardiol;
18(6): 577-89, 2013 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24118671
9.
Investigating the effect of sotalol on the repolarization intervals in healthy young individuals.
J Electrocardiol;
41(6): 595-602, 2008.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18801493
10.
Can Bias Evaluation Provide Protection Against False-Negative Results in QT Studies Without a Positive Control Using Exposure-Response Analysis?
J Clin Pharmacol;
57(1): 85-95, 2017 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27271102
11.
Concentration-Response Modeling of ECG Data From Early-Phase Clinical Studies as an Alternative Clinical and Regulatory Approach to Assessing QT Risk - Experience From the Development Program of Lemborexant.
J Clin Pharmacol;
57(1): 96-104, 2017 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27338807
12.
Differentiating the Effect of an Opioid Agonist on Cardiac Repolarization From µ-Receptor-mediated, Indirect Effects on the QT Interval: A Randomized, 3-way Crossover Study in Healthy Subjects.
Clin Ther;
38(2): 315-26, 2016 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26749217
13.
Detection of ECG effects of (2R,4R)-monatin, a sweet flavored isomer of a component first identified in the root bark of the Sclerochitin ilicifolius plant.
Food Chem Toxicol;
91: 217-24, 2016 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26747976
14.
Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients.
Clin Pharmacol Drug Dev;
5(6): 460-468, 2016 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27870477
15.
A thorough QT study with dalbavancin: a novel lipoglycopeptide antibiotic for the treatment of acute bacterial skin and skin-structure infections.
Int J Antimicrob Agents;
45(4): 393-8, 2015 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25681068
16.
Effect of ponesimod, a selective S1P1 receptor modulator, on the QT interval in healthy individuals.
Basic Clin Pharmacol Toxicol;
116(5): 429-37, 2015 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25287214
17.
A thorough QT study in the context of an uptitration regimen with selexipag, a selective oral prostacyclin receptor agonist.
Drug Des Devel Ther;
9: 175-85, 2015.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25552906
18.
Effect of ceralifimod (ONO-4641) on lymphocytes and cardiac function: Randomized, double-blind, placebo-controlled trial with an open-label fingolimod arm.
J Clin Pharmacol;
55(9): 1051-60, 2015 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25855155
19.
Effect of lenvatinib (E7080) on the QTc interval: results from a thorough QT study in healthy volunteers.
Cancer Chemother Pharmacol;
73(6): 1109-17, 2014 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24658627
20.
Albiglutide Does Not Prolong QTc Interval in Healthy Subjects: A Thorough ECG Study.
Diabetes Ther;
5(1): 141-53, 2014 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24510375